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Q2H7G2

- KYNU2_CHAGB

UniProt

Q2H7G2 - KYNU2_CHAGB

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Protein

Kynureninase 2

Gene

BNA5-2

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei171 – 1711Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei172 – 1721Pyridoxal phosphateUniRule annotation
Binding sitei290 – 2901Pyridoxal phosphateUniRule annotation
Binding sitei293 – 2931Pyridoxal phosphateUniRule annotation
Binding sitei315 – 3151Pyridoxal phosphateUniRule annotation
Binding sitei379 – 3791Pyridoxal phosphateUniRule annotation
Binding sitei407 – 4071Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase 2UniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5-2UniRule annotation
L-kynurenine hydrolase 2UniRule annotation
Gene namesi
Name:BNA5-2UniRule annotation
ORF Names:CHGG_05403
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Kynureninase 2PRO_0000356975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei316 – 3161N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2H7G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

InParanoidiQ2H7G2.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2H7G2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTEYQSFVE TLRAGQKPEF PAHAKTIEYA RELDAHDKLS QLRSDFNIPT
60 70 80 90 100
KGSLRKKALD GGVAGETKEP RVPNGVSSAT KPNGTVNSDL KDDEASIYFV
110 120 130 140 150
GNSLGAQPKC IRQYIDAHLE TWASIGVNGH FTSFDNSPLA SWQDMAAACA
160 170 180 190 200
AQSVDLVGAK SANEIIYMNT LTVNLHLMMA SFYRPTAKRH KIIAEWKPFP
210 220 230 240 250
SDSYALASQL HWHGLAPATS LIEIHPPNPT GSSPPTLTLT TSHILATIDA
260 270 280 290 300
HADSTALLLL PGIQYYTGQL FDMARITRHA RARGIVVGWD LAHAVGNVEL
310 320 330 340 350
ELHAWGVDFA VWCTYKYLNA GPGALGGVFV HGRHHSFHRG GGGSGGVGGG
360 370 380 390 400
RGEGGDGDGG DGGDGDGMAL GYRHRLAGWY GADKAVRFEM EKVFWPAEGA
410 420 430 440 450
AGWQVSNPSV VDLACVRATL GMFERVGMRA LRDKAVLLTG YLEWLLLGLL
460 470 480 490 500
ADGVGKGGDG EAAFRIITPG HPADRGSQLS LLLRGGLLEG VSKELADGGV
510 520 530
VVDVRKPDVI RVAPVPMYCR FEDVWGFITV FNRALDRCA
Length:539
Mass (Da):57,881
Last modified:March 21, 2006 - v1
Checksum:i6C22ABAB563342EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408031 Genomic DNA. Translation: EAQ88784.1.
RefSeqiXP_001221498.1. XM_001221497.1.

Genome annotation databases

GeneIDi4391213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408031 Genomic DNA. Translation: EAQ88784.1 .
RefSeqi XP_001221498.1. XM_001221497.1.

3D structure databases

ProteinModelPortali Q2H7G2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4391213.

Phylogenomic databases

InParanoidi Q2H7G2.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiKYNU2_CHAGB
AccessioniPrimary (citable) accession number: Q2H7G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3