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Protein

Kynureninase 2

Gene

BNA5-2

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase 2 (BNA5-2), Kynureninase 1 (BNA5-1)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase 2 (BNA5-2), Kynureninase 1 (BNA5-1)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei172Pyridoxal phosphateUniRule annotation1
Binding sitei290Pyridoxal phosphateUniRule annotation1
Binding sitei293Pyridoxal phosphateUniRule annotation1
Binding sitei315Pyridoxal phosphateUniRule annotation1
Binding sitei379Pyridoxal phosphateUniRule annotation1
Binding sitei407Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase 2UniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5-2UniRule annotation
L-kynurenine hydrolase 2UniRule annotation
Gene namesi
Name:BNA5-2UniRule annotation
ORF Names:CHGG_05403
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003569751 – 539Kynureninase 2Add BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi306901.XP_001221498.1.

Structurei

3D structure databases

ProteinModelPortaliQ2H7G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 202Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3846. Eukaryota.
COG3844. LUCA.
InParanoidiQ2H7G2.
OrthoDBiEOG092C20ON.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 3 hits.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2H7G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTEYQSFVE TLRAGQKPEF PAHAKTIEYA RELDAHDKLS QLRSDFNIPT
60 70 80 90 100
KGSLRKKALD GGVAGETKEP RVPNGVSSAT KPNGTVNSDL KDDEASIYFV
110 120 130 140 150
GNSLGAQPKC IRQYIDAHLE TWASIGVNGH FTSFDNSPLA SWQDMAAACA
160 170 180 190 200
AQSVDLVGAK SANEIIYMNT LTVNLHLMMA SFYRPTAKRH KIIAEWKPFP
210 220 230 240 250
SDSYALASQL HWHGLAPATS LIEIHPPNPT GSSPPTLTLT TSHILATIDA
260 270 280 290 300
HADSTALLLL PGIQYYTGQL FDMARITRHA RARGIVVGWD LAHAVGNVEL
310 320 330 340 350
ELHAWGVDFA VWCTYKYLNA GPGALGGVFV HGRHHSFHRG GGGSGGVGGG
360 370 380 390 400
RGEGGDGDGG DGGDGDGMAL GYRHRLAGWY GADKAVRFEM EKVFWPAEGA
410 420 430 440 450
AGWQVSNPSV VDLACVRATL GMFERVGMRA LRDKAVLLTG YLEWLLLGLL
460 470 480 490 500
ADGVGKGGDG EAAFRIITPG HPADRGSQLS LLLRGGLLEG VSKELADGGV
510 520 530
VVDVRKPDVI RVAPVPMYCR FEDVWGFITV FNRALDRCA
Length:539
Mass (Da):57,881
Last modified:March 21, 2006 - v1
Checksum:i6C22ABAB563342EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408031 Genomic DNA. Translation: EAQ88784.1.
RefSeqiXP_001221498.1. XM_001221497.1.

Genome annotation databases

EnsemblFungiiEAQ88784; EAQ88784; CHGG_05403.
GeneIDi4391213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408031 Genomic DNA. Translation: EAQ88784.1.
RefSeqiXP_001221498.1. XM_001221497.1.

3D structure databases

ProteinModelPortaliQ2H7G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306901.XP_001221498.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAQ88784; EAQ88784; CHGG_05403.
GeneIDi4391213.

Phylogenomic databases

eggNOGiKOG3846. Eukaryota.
COG3844. LUCA.
InParanoidiQ2H7G2.
OrthoDBiEOG092C20ON.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 3 hits.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKYNU2_CHAGB
AccessioniPrimary (citable) accession number: Q2H7G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.