Q2H6X2 (ATG1_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase ATG1
EC=2.7.11.1

Alternative name(s):
Autophagy-related protein 1

Gene names

Name:	ATG1
ORF Names:	CHGG_05593

Organism

Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]

Taxonomic identifier

306901 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium

Protein attributes

Sequence length	943 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 943	943	Serine/threonine-protein kinase ATG1		PRO_0000317792
Regions
	Domain	22 – 327	306	Protein kinase
	Nucleotide binding	28 – 36	9	ATP By similarity
Sites
	Active site	165	1	Proton acceptor By similarity
	Binding site	51	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2H6X2 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 40AA99FA21695DAC	FASTA	943	104,057
	10 20 30 40 50 60 MSERTSSSRR SKPASDDTIG NFVIDKEIGK GSFAQVYSGR HKVTGALVAI KSVELARLNT 70 80 90 100 110 120 KLKDNLYGEI EILKRLRHPH IVALHDCVES RTHINLIMEY CELGDLSLFI KKRDKLITNP 130 140 150 160 170 180 GTHELARKYP VAPNSGLNEV VIRHFLKQLT SAIRFLREAN LIHRDVKPQN LLLLPSPQYR 190 200 210 220 230 240 EANKMHKQIL SASHDSFTPA AGLPSLPMLK LADFGFARVL PSTSLAETLC GSPLYMAPEI 250 260 270 280 290 300 LRYEKYDAKA DLWSVGTVLY EMATGRPPFR AVNHVDLLRK IEASGDVIRF SRECVVSSEV 310 320 330 340 350 360 KGLVRALLKR NPVERISFED FFHHPVITGP IPGLVEDDIP KPEKPVLAET KSRIRRANPE 370 380 390 400 410 420 LSHTRRSRAG PHLLATPIEP KPNPLEQVAS PRLSYSPRQE ADEGLGIRRP LAQPSTSAPV 430 440 450 460 470 480 RPISYVDRSR RYSNASTKVP ARDTPPPPHE GSNRSRPKSA VSRPLTDEDK AAQDVAFERD 490 500 510 520 530 540 YIIIDKTAVE VNALADQISL YPQQGQPKSG GQIVRRATQQ GHPTSTTGAV PSHPGRNAQG 550 560 570 580 590 600 GRNDHYRKAS HDKTLSGSPG ATTSVISKAI QDASLRLFGF KYSPQMLSKG QSPPQIYSPF 610 620 630 640 650 660 PAYPTPSTPA GLIMDGKQSA PVDEDSRVAQ CIEDYATRSD VVYGFAEVKY KQLVPLAPSV 670 680 690 700 710 720 EHGLGGVPTD RMGEEEEGLT MDAVVSLSEE ALVLYVKALS LLAKSMDIAS LWWSRKSRPE 730 740 750 760 770 780 SSNNVHSATR DSVNTQALVL KINAAVQWIR SRFNEVLEKA EIVRLRLVEA QNQLPEEHPS 790 800 810 820 830 840 HPSNRPPETS ALGGSSGGQA TFPSVGISAE KLMYDRAVEM SRTAAINEIA SEDLPGCEIS 850 860 870 880 890 900 YVTAVRMLEA VLDSDDDHLP KRRVSTSSKE EQSVAAQDAS DDMSSDDKQA VQKMVQMINT 910 920 930 940 RLTYLRKRMH TIAAASKAQQ QQQQQQVVVR RRSGDVTPRS VPT

References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome." The Broad Institute Genome Sequencing Platform Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408031 Genomic DNA. Translation: EAQ88974.1.
RefSeq	XP_001221688.1. XM_001221687.1.
3D structure databases
ProteinModelPortal	Q2H6X2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4390436.
Phylogenomic databases
OrthoDB	EOG43XZCK.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR022708. Ser/Thr_kinase_C. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
Pfam	PF12063. DUF3543. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_CHAGB

Accession

Primary (citable) accession number: Q2H6X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program