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Reviewed, UniProtKB/Swiss-Prot Q2H6X2 (ATG1_CHAGB)

Last modified January 19, 2010. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1
Gene names
Name: ATG1
ORF Names: CHGG_05593
OrganismChaetomium globosum (Soil fungus) [Complete proteome]
Taxonomic identifier38033 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium

Protein attributes

Sequence length943 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processAutophagy
Protein transport
Transport
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processautophagy

Inferred from electronic annotation. Source: UniProtKB-KW

protein amino acid phosphorylation

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 943943Serine/threonine-protein kinase ATG1
PRO_0000317792

Regions

Domain22 – 327306Protein kinase
Nucleotide binding28 – 369ATP By similarity

Sites

Active site1651Proton acceptor By similarity
Binding site511ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2H6X2-1 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 40AA99FA21695DAC

FASTA943104,057
        10         20         30         40         50         60 
MSERTSSSRR SKPASDDTIG NFVIDKEIGK GSFAQVYSGR HKVTGALVAI KSVELARLNT 

        70         80         90        100        110        120 
KLKDNLYGEI EILKRLRHPH IVALHDCVES RTHINLIMEY CELGDLSLFI KKRDKLITNP 

       130        140        150        160        170        180 
GTHELARKYP VAPNSGLNEV VIRHFLKQLT SAIRFLREAN LIHRDVKPQN LLLLPSPQYR 

       190        200        210        220        230        240 
EANKMHKQIL SASHDSFTPA AGLPSLPMLK LADFGFARVL PSTSLAETLC GSPLYMAPEI 

       250        260        270        280        290        300 
LRYEKYDAKA DLWSVGTVLY EMATGRPPFR AVNHVDLLRK IEASGDVIRF SRECVVSSEV 

       310        320        330        340        350        360 
KGLVRALLKR NPVERISFED FFHHPVITGP IPGLVEDDIP KPEKPVLAET KSRIRRANPE 

       370        380        390        400        410        420 
LSHTRRSRAG PHLLATPIEP KPNPLEQVAS PRLSYSPRQE ADEGLGIRRP LAQPSTSAPV 

       430        440        450        460        470        480 
RPISYVDRSR RYSNASTKVP ARDTPPPPHE GSNRSRPKSA VSRPLTDEDK AAQDVAFERD 

       490        500        510        520        530        540 
YIIIDKTAVE VNALADQISL YPQQGQPKSG GQIVRRATQQ GHPTSTTGAV PSHPGRNAQG 

       550        560        570        580        590        600 
GRNDHYRKAS HDKTLSGSPG ATTSVISKAI QDASLRLFGF KYSPQMLSKG QSPPQIYSPF 

       610        620        630        640        650        660 
PAYPTPSTPA GLIMDGKQSA PVDEDSRVAQ CIEDYATRSD VVYGFAEVKY KQLVPLAPSV 

       670        680        690        700        710        720 
EHGLGGVPTD RMGEEEEGLT MDAVVSLSEE ALVLYVKALS LLAKSMDIAS LWWSRKSRPE 

       730        740        750        760        770        780 
SSNNVHSATR DSVNTQALVL KINAAVQWIR SRFNEVLEKA EIVRLRLVEA QNQLPEEHPS 

       790        800        810        820        830        840 
HPSNRPPETS ALGGSSGGQA TFPSVGISAE KLMYDRAVEM SRTAAINEIA SEDLPGCEIS 

       850        860        870        880        890        900 
YVTAVRMLEA VLDSDDDHLP KRRVSTSSKE EQSVAAQDAS DDMSSDDKQA VQKMVQMINT 

       910        920        930        940 
RLTYLRKRMH TIAAASKAQQ QQQQQQVVVR RRSGDVTPRS VPT 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408031 Genomic DNA. Translation: EAQ88974.1.
RefSeqXP_001221688.1.

3D structure databases

SMRQ2H6X2. Positions 20-329.
ModBaseSearch...

Genome annotation databases

GeneID4390436.

Phylogenomic databases

OrthoDBEOG98D2C4.
PhylomeDBQ2H6X2.

Enzyme and pathway databases

BRENDA2.7.11.1. 81575.

Family and domain databases

InterProIPR020636. Ca/CaM-dep_prot_kinase-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR020656. Ser/Thr_prot_kinase_ATG1.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PANTHERPTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit.
PTHR22982:SF39. Ser/Thr_prot_kinase_ATG1. 1 hit.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATG1_CHAGB
AccessionPrimary (citable) accession number: Q2H6X2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 21, 2006
Last modified: January 19, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents