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Protein

Eukaryotic translation initiation factor 3 subunit D

Gene

CHGG_05977

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit DUniRule annotation
Short name:
eIF3dUniRule annotation
Gene namesi
ORF Names:CHGG_05977
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003641721 – 584Eukaryotic translation initiation factor 3 subunit DAdd BLAST584

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi306901.XP_001222072.1.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 326RNA gateBy similarityAdd BLAST15

Domaini

The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Sequence similaritiesi

Belongs to the eIF-3 subunit D family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2479. Eukaryota.
ENOG410XP1E. LUCA.
InParanoidiQ2H5T8.
OrthoDBiEOG092C1S0N.

Family and domain databases

HAMAPiMF_03003. eIF3d. 1 hit.
InterProiIPR007783. eIF3d.
[Graphical view]
PANTHERiPTHR12399. PTHR12399. 1 hit.
PfamiPF05091. eIF-3_zeta. 1 hit.
[Graphical view]
PIRSFiPIRSF016281. EIF-3_zeta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2H5T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEYTAGTSP LVDLINSLPD SDGTWGPPIT NETTLNGVPY APFSKSDKLG
60 70 80 90 100
RMADWTDAKD GRDGRGRQQY NRNYRDQQVY GAGSASLFAP PAAEDEASFS
110 120 130 140 150
VVSNVRDTGK TRFGRGAIFT RGRGQRGRGG QDTRGGGRQQ FQRGGRGGQQ
160 170 180 190 200
YGGGGYSDRG GGRGGGARGR RFGWKDYDKP QRNRDASVNI RPDWKLLEEI
210 220 230 240 250
DYNRLSKLNL DTDEGEDVDS YGFLYYYDRS YDKPPVKSAE RKLAVVDRAV
260 270 280 290 300
YNVTTSSDPI IQELAEKDEA TIFATDSILS MLMCAPRSMY PWDIIIVRQG
310 320 330 340 350
NKVFLDKRDN AALDMVTVNE NAADAPLEAS EGSKDVINQP GALAEEATYI
360 370 380 390 400
NHNFVNQVVL ESSNQKVDMA NENPFHSASE ETEPPASKAY KYRRFDLSTS
410 420 430 440 450
EETPTYLVVR TELDAVQKNP TSGEDQFVTV HALNEFDSKA QGSGGALDWR
460 470 480 490 500
TKLVSQRGAV VATEMKNNSC KLARWTVQSI LAKADVMKLG FVSRVTPKAN
510 520 530 540 550
DKHVILGCVG WKPKDFANQM NLQLSNGWGI VRTIADMCLQ REEGKYVLVK
560 570 580
DPNKNILRLY EVPANGLDDD DEGPEPEGVA EEED
Length:584
Mass (Da):64,534
Last modified:March 21, 2006 - v1
Checksum:iE823F4EB43B38C58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408031 Genomic DNA. Translation: EAQ89358.1.
RefSeqiXP_001222072.1. XM_001222071.1.

Genome annotation databases

EnsemblFungiiEAQ89358; EAQ89358; CHGG_05977.
GeneIDi4391386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408031 Genomic DNA. Translation: EAQ89358.1.
RefSeqiXP_001222072.1. XM_001222071.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306901.XP_001222072.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAQ89358; EAQ89358; CHGG_05977.
GeneIDi4391386.

Phylogenomic databases

eggNOGiKOG2479. Eukaryota.
ENOG410XP1E. LUCA.
InParanoidiQ2H5T8.
OrthoDBiEOG092C1S0N.

Family and domain databases

HAMAPiMF_03003. eIF3d. 1 hit.
InterProiIPR007783. eIF3d.
[Graphical view]
PANTHERiPTHR12399. PTHR12399. 1 hit.
PfamiPF05091. eIF-3_zeta. 1 hit.
[Graphical view]
PIRSFiPIRSF016281. EIF-3_zeta. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3D_CHAGB
AccessioniPrimary (citable) accession number: Q2H5T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.