Q2H2D7 (MTLD_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
Short name=M1PDH
Short name=MPD
Short name=MPDH
EC=1.1.1.17

Gene names

ORF Names:

CHGG_04059

Organism

Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]

Taxonomic identifier

306901 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371525
Regions
	Nucleotide binding	10 – 21	12	NAD By similarity
Sites
	Active site	221	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2H2D7 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 6C1802D7C566865A	FASTA	398	44,047
	10 20 30 40 50 60 MVQRNAPKKA VHFGAGNIGR GFVACFLHNS GYEVIFAEVN DTTVQKLNSQ KSYKVIEVGA 70 80 90 100 110 120 DGTSESTITN YRAINSRLNE AELVQEIATA DLVTCSVGPH ILKFLAPVIA KGIDARSTDL 130 140 150 160 170 180 TPVAVIACEN AIGATDTLAE FIKAPENTNP DRLADYDKRA RFANSAIDRI VPAQDPDAGL 190 200 210 220 230 240 DVRLEKFYEW VVERTPFADH EPPAVEGIHW VDNLQPFIER KLYTVNTGHA TAAYHGYIRR 250 260 270 280 290 300 KSTVYDALQD REIQEEVKKA LANTASLITQ KHGIPQDEQQ AYVDKIVRRI SNPHLEDAVE 310 320 330 340 350 360 RVGRAPLRKL SRKERFIGPA AELAEHGKDC GALLDAAEMA FRFQNVEGDD ESFKLAEIME 370 380 390 QNGPEDVVKQ VCGLEPKEKL FPAVVDVVKR VQADTQSD

References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome." The Broad Institute Genome Sequencing Platform Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408032 Genomic DNA. Translation: EAQ87440.1.
RefSeq	XP_001223273.1. XM_001223272.1.
3D structure databases
ProteinModelPortal	Q2H2D7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4392871.
Phylogenomic databases
OrthoDB	EOG469V3C.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_CHAGB

Accession

Primary (citable) accession number: Q2H2D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program