Reviewed, UniProtKB/Swiss-Prot Q2H2D7 (MTLD_CHAGB)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
      Short name=M1PDH
      Short name=MPDH
      Short name=MPD
    EC=1.1.1.17

Gene names

ORF Names:

CHGG_04059

Organism

Chaetomium globosum (Soil fungus) [Complete proteome]

Taxonomic identifier

38033 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371525
Regions
	Nucleotide binding	10 – 21	12	NAD By similarity
Sites
	Active site	221	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2H2D7-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 6C1802D7C566865A	FASTA	398	44,047
	10 20 30 40 50 60 MVQRNAPKKA VHFGAGNIGR GFVACFLHNS GYEVIFAEVN DTTVQKLNSQ KSYKVIEVGA 70 80 90 100 110 120 DGTSESTITN YRAINSRLNE AELVQEIATA DLVTCSVGPH ILKFLAPVIA KGIDARSTDL 130 140 150 160 170 180 TPVAVIACEN AIGATDTLAE FIKAPENTNP DRLADYDKRA RFANSAIDRI VPAQDPDAGL 190 200 210 220 230 240 DVRLEKFYEW VVERTPFADH EPPAVEGIHW VDNLQPFIER KLYTVNTGHA TAAYHGYIRR 250 260 270 280 290 300 KSTVYDALQD REIQEEVKKA LANTASLITQ KHGIPQDEQQ AYVDKIVRRI SNPHLEDAVE 310 320 330 340 350 360 RVGRAPLRKL SRKERFIGPA AELAEHGKDC GALLDAAEMA FRFQNVEGDD ESFKLAEIME 370 380 390 QNGPEDVVKQ VCGLEPKEKL FPAVVDVVKR VQADTQSD

References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome." Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / IFO 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH408032 Genomic DNA. Translation: EAQ87440.1.
RefSeq	XP_001223273.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4392871.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_CHAGB

Accession

Primary (citable) accession number: Q2H2D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)