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Q2H0D3

- NTE1_CHAGB

UniProt

Q2H0D3 - NTE1_CHAGB

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Protein
Lysophospholipase NTE1
Gene
NTE1, CHGG_04763
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1250 – 12501 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi670 – 789120cNMP 1
Add
BLAST
Nucleotide bindingi837 – 957121cNMP 2
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BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:CHGG_04763
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050Cytoplasmic By similarity
Add
BLAST
Transmembranei51 – 7121Helical; Reviewed prediction
Add
BLAST
Topological domaini72 – 9625Lumenal By similarity
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Topological domaini118 – 15211404Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15211521Lysophospholipase NTE1
PRO_0000295316Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2H0D3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1217 – 1381165Patatin
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BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1248 – 12525GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2H0D3-1 [UniParc]FASTAAdd to Basket

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MDVVNSTARA AVTSATAVTA VTGTGDRHPN PLSSAVAAAS DVANAHGSSS     50
WLGLFARVVL WLLQFVSMVL YYAIKLATIS VPTLLYTLFS TSLTVTMNAT 100
TLMLIVAAMI GAISWVVRYR YLNMYSRLPP EPQRKEPDVD LFPDTHEEGI 150
KSGLSNYFDE FLSAIKIFGY LERPVFHELT RSMQTRKLIA GESFNLEEEK 200
GFCLVVDGLV EIFVKSSSYN RRYPHGPYFS PNSEAPSSDD EHPAPGQQRY 250
QLLTEVRNGA PMSSLFSIMS LFTEDVPLRH ADEDNSEPGT TTHSGLFPNY 300
PASADFRKSR VRMDSVPNTP QMDASASSSA NNLPGQLDRG LPHVPPISLD 350
GTGFSKPQRP VPKRSNTTSA HPDIIARATV DTTVAIIPAS AFRRLIKIYP 400
KATAHIVHVI LSRFQRVTLA TAYNYLGLTN EVLQIERQML KYTTQQLPNH 450
LRGDALDRLK EKFKREVERM GEEDDVSKGI ALHNARAGRR RRSTATLRKE 500
AALQAFSKQR NISSMSGSSL AIPNAGDLVT HLQQSRGGGN RAQSVAFTDG 550
PSPHLDVERE AVSPLAQRTF DPFVTPRSIH VALEKRETLD EDNLFRESIL 600
ECMFRSIGLT GSGGSNKDAD SNQASPRLIS FDQRRQKALY TNHAFGFMDG 650
LDGSADGDTE SITSAGLSLP ASPNPQFLAQ EMRDEMEIVF FPKGSVLVEQ 700
GERNPGLYYV VDGFLDICTQ EDAAASDVVH PTSRTSLHAM DSAQSIRSPQ 750
RSPQPFAESM RSGNKVDDAE IKSKPNRRSV ALIKPGGLAG YVGTISSYRS 800
FIEVVAKTDV YVGFLPLTSI ERIVDRYPIV LLTMAKRLTN LLPRLILHID 850
FALEWLQVNA GQVIFHEGDE SEAIYIVLNG RLRLVEDRKD GGMNVKAEYG 900
QGESIGELEV LTETSRSGTL HAIRDTELVK FPRTLFNSLA QEHPNITIKI 950
SKIIASRMRA LIDDPSTMLG IKDSSGRSSI NKSSTTLNLR TVAVLPVSAG 1000
VPVVEFSNRL LSALTEVGAP NGATSLNSAA VLNHLGKHAF NRMGKLKLSQ 1050
YLADLEEKYG LVIYVADTNV NAPWTQTCVA QADCVLMVGL ADGSPEIGEY 1100
ERFMLGMKST ARKILVLLHQ ERYSNSGLTR KWLKNRVWIN GGHFHVQMTY 1150
SPNAVPIHPP AKPSGPTLRE RVQILQAEIQ KYTSRKVRHS PFYSPDAPFK 1200
GDFHRLARRL CGKSVGLVLG GGGARGIAQI GIIRAMQEAG IPIDIVGGTS 1250
IGAFIGALYA RHADFVPIVN AAKKFSGRMA SMWRFALDLT YPSASYTTGH 1300
EFNRGIFKAF GNTQIEDFWL DYYCNTTNIS KSRAEFHTSG YAWWYVRASM 1350
SLAGLLLPLC DEGSMLLDGG YVDNLTVSHM KSLGSDVIFA VDVGALDDNT 1400
PQAFGDSLSG MWAFFNRWNP FSSVANPPTL AEIQARLAYV SSVDALERAK 1450
TLPGCIYMRP PIEEYGTLDF GKFMEIYGVG YKYGQEFLAK LRERGGVLPI 1500
GEEMGGKKGL RRTMAPRRAS I 1521
Length:1,521
Mass (Da):167,339
Last modified:July 24, 2007 - v2
Checksum:i4120EA5A39BDAFF2
GO

Sequence cautioni

The sequence EAQ88144.1 differs from that shown. Reason: Frameshift at positions 1374 and 1405.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408032 Genomic DNA. Translation: EAQ88144.1. Frameshift.
RefSeqiXP_001223977.1. XM_001223976.1.

Genome annotation databases

GeneIDi4392000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408032 Genomic DNA. Translation: EAQ88144.1 . Frameshift.
RefSeqi XP_001223977.1. XM_001223976.1.

3D structure databases

ProteinModelPortali Q2H0D3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4392000.

Phylogenomic databases

OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiNTE1_CHAGB
AccessioniPrimary (citable) accession number: Q2H0D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi