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Q2H0D3 (NTE1_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
ORF Names:CHGG_04763
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]
Taxonomic identifier306901 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium

Protein attributes

Sequence length1521 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence EAQ88144.1 differs from that shown. Reason: Frameshift at positions 1374 and 1405.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15211521Lysophospholipase NTE1
PRO_0000295316

Regions

Topological domain1 – 5050Cytoplasmic By similarity
Transmembrane51 – 7121Helical; Potential
Topological domain72 – 9625Lumenal By similarity
Transmembrane97 – 11721Helical; Potential
Topological domain118 – 15211404Cytoplasmic By similarity
Domain1217 – 1381165Patatin
Nucleotide binding670 – 789120cNMP 1
Nucleotide binding837 – 957121cNMP 2
Motif1248 – 12525GXSXG

Sites

Active site12501 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2H0D3 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 4120EA5A39BDAFF2

FASTA1,521167,339
        10         20         30         40         50         60 
MDVVNSTARA AVTSATAVTA VTGTGDRHPN PLSSAVAAAS DVANAHGSSS WLGLFARVVL 

        70         80         90        100        110        120 
WLLQFVSMVL YYAIKLATIS VPTLLYTLFS TSLTVTMNAT TLMLIVAAMI GAISWVVRYR 

       130        140        150        160        170        180 
YLNMYSRLPP EPQRKEPDVD LFPDTHEEGI KSGLSNYFDE FLSAIKIFGY LERPVFHELT 

       190        200        210        220        230        240 
RSMQTRKLIA GESFNLEEEK GFCLVVDGLV EIFVKSSSYN RRYPHGPYFS PNSEAPSSDD 

       250        260        270        280        290        300 
EHPAPGQQRY QLLTEVRNGA PMSSLFSIMS LFTEDVPLRH ADEDNSEPGT TTHSGLFPNY 

       310        320        330        340        350        360 
PASADFRKSR VRMDSVPNTP QMDASASSSA NNLPGQLDRG LPHVPPISLD GTGFSKPQRP 

       370        380        390        400        410        420 
VPKRSNTTSA HPDIIARATV DTTVAIIPAS AFRRLIKIYP KATAHIVHVI LSRFQRVTLA 

       430        440        450        460        470        480 
TAYNYLGLTN EVLQIERQML KYTTQQLPNH LRGDALDRLK EKFKREVERM GEEDDVSKGI 

       490        500        510        520        530        540 
ALHNARAGRR RRSTATLRKE AALQAFSKQR NISSMSGSSL AIPNAGDLVT HLQQSRGGGN 

       550        560        570        580        590        600 
RAQSVAFTDG PSPHLDVERE AVSPLAQRTF DPFVTPRSIH VALEKRETLD EDNLFRESIL 

       610        620        630        640        650        660 
ECMFRSIGLT GSGGSNKDAD SNQASPRLIS FDQRRQKALY TNHAFGFMDG LDGSADGDTE 

       670        680        690        700        710        720 
SITSAGLSLP ASPNPQFLAQ EMRDEMEIVF FPKGSVLVEQ GERNPGLYYV VDGFLDICTQ 

       730        740        750        760        770        780 
EDAAASDVVH PTSRTSLHAM DSAQSIRSPQ RSPQPFAESM RSGNKVDDAE IKSKPNRRSV 

       790        800        810        820        830        840 
ALIKPGGLAG YVGTISSYRS FIEVVAKTDV YVGFLPLTSI ERIVDRYPIV LLTMAKRLTN 

       850        860        870        880        890        900 
LLPRLILHID FALEWLQVNA GQVIFHEGDE SEAIYIVLNG RLRLVEDRKD GGMNVKAEYG 

       910        920        930        940        950        960 
QGESIGELEV LTETSRSGTL HAIRDTELVK FPRTLFNSLA QEHPNITIKI SKIIASRMRA 

       970        980        990       1000       1010       1020 
LIDDPSTMLG IKDSSGRSSI NKSSTTLNLR TVAVLPVSAG VPVVEFSNRL LSALTEVGAP 

      1030       1040       1050       1060       1070       1080 
NGATSLNSAA VLNHLGKHAF NRMGKLKLSQ YLADLEEKYG LVIYVADTNV NAPWTQTCVA 

      1090       1100       1110       1120       1130       1140 
QADCVLMVGL ADGSPEIGEY ERFMLGMKST ARKILVLLHQ ERYSNSGLTR KWLKNRVWIN 

      1150       1160       1170       1180       1190       1200 
GGHFHVQMTY SPNAVPIHPP AKPSGPTLRE RVQILQAEIQ KYTSRKVRHS PFYSPDAPFK 

      1210       1220       1230       1240       1250       1260 
GDFHRLARRL CGKSVGLVLG GGGARGIAQI GIIRAMQEAG IPIDIVGGTS IGAFIGALYA 

      1270       1280       1290       1300       1310       1320 
RHADFVPIVN AAKKFSGRMA SMWRFALDLT YPSASYTTGH EFNRGIFKAF GNTQIEDFWL 

      1330       1340       1350       1360       1370       1380 
DYYCNTTNIS KSRAEFHTSG YAWWYVRASM SLAGLLLPLC DEGSMLLDGG YVDNLTVSHM 

      1390       1400       1410       1420       1430       1440 
KSLGSDVIFA VDVGALDDNT PQAFGDSLSG MWAFFNRWNP FSSVANPPTL AEIQARLAYV 

      1450       1460       1470       1480       1490       1500 
SSVDALERAK TLPGCIYMRP PIEEYGTLDF GKFMEIYGVG YKYGQEFLAK LRERGGVLPI 

      1510       1520 
GEEMGGKKGL RRTMAPRRAS I 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408032 Genomic DNA. Translation: EAQ88144.1. Frameshift.
RefSeqXP_001223977.1. XM_001223976.1.

3D structure databases

ProteinModelPortalQ2H0D3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4392000.

Phylogenomic databases

OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_CHAGB
AccessionPrimary (citable) accession number: Q2H0D3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families