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Q2H0D3

- NTE1_CHAGB

UniProt

Q2H0D3 - NTE1_CHAGB

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1250 – 12501By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi670 – 789120cNMP 1Add
BLAST
Nucleotide bindingi837 – 957121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:CHGG_04763
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050CytoplasmicBy similarityAdd
BLAST
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Topological domaini72 – 9625LumenalBy similarityAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Topological domaini118 – 15211404CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15211521Lysophospholipase NTE1PRO_0000295316Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2H0D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1217 – 1381165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1248 – 12525GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ2H0D3.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2H0D3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVVNSTARA AVTSATAVTA VTGTGDRHPN PLSSAVAAAS DVANAHGSSS
60 70 80 90 100
WLGLFARVVL WLLQFVSMVL YYAIKLATIS VPTLLYTLFS TSLTVTMNAT
110 120 130 140 150
TLMLIVAAMI GAISWVVRYR YLNMYSRLPP EPQRKEPDVD LFPDTHEEGI
160 170 180 190 200
KSGLSNYFDE FLSAIKIFGY LERPVFHELT RSMQTRKLIA GESFNLEEEK
210 220 230 240 250
GFCLVVDGLV EIFVKSSSYN RRYPHGPYFS PNSEAPSSDD EHPAPGQQRY
260 270 280 290 300
QLLTEVRNGA PMSSLFSIMS LFTEDVPLRH ADEDNSEPGT TTHSGLFPNY
310 320 330 340 350
PASADFRKSR VRMDSVPNTP QMDASASSSA NNLPGQLDRG LPHVPPISLD
360 370 380 390 400
GTGFSKPQRP VPKRSNTTSA HPDIIARATV DTTVAIIPAS AFRRLIKIYP
410 420 430 440 450
KATAHIVHVI LSRFQRVTLA TAYNYLGLTN EVLQIERQML KYTTQQLPNH
460 470 480 490 500
LRGDALDRLK EKFKREVERM GEEDDVSKGI ALHNARAGRR RRSTATLRKE
510 520 530 540 550
AALQAFSKQR NISSMSGSSL AIPNAGDLVT HLQQSRGGGN RAQSVAFTDG
560 570 580 590 600
PSPHLDVERE AVSPLAQRTF DPFVTPRSIH VALEKRETLD EDNLFRESIL
610 620 630 640 650
ECMFRSIGLT GSGGSNKDAD SNQASPRLIS FDQRRQKALY TNHAFGFMDG
660 670 680 690 700
LDGSADGDTE SITSAGLSLP ASPNPQFLAQ EMRDEMEIVF FPKGSVLVEQ
710 720 730 740 750
GERNPGLYYV VDGFLDICTQ EDAAASDVVH PTSRTSLHAM DSAQSIRSPQ
760 770 780 790 800
RSPQPFAESM RSGNKVDDAE IKSKPNRRSV ALIKPGGLAG YVGTISSYRS
810 820 830 840 850
FIEVVAKTDV YVGFLPLTSI ERIVDRYPIV LLTMAKRLTN LLPRLILHID
860 870 880 890 900
FALEWLQVNA GQVIFHEGDE SEAIYIVLNG RLRLVEDRKD GGMNVKAEYG
910 920 930 940 950
QGESIGELEV LTETSRSGTL HAIRDTELVK FPRTLFNSLA QEHPNITIKI
960 970 980 990 1000
SKIIASRMRA LIDDPSTMLG IKDSSGRSSI NKSSTTLNLR TVAVLPVSAG
1010 1020 1030 1040 1050
VPVVEFSNRL LSALTEVGAP NGATSLNSAA VLNHLGKHAF NRMGKLKLSQ
1060 1070 1080 1090 1100
YLADLEEKYG LVIYVADTNV NAPWTQTCVA QADCVLMVGL ADGSPEIGEY
1110 1120 1130 1140 1150
ERFMLGMKST ARKILVLLHQ ERYSNSGLTR KWLKNRVWIN GGHFHVQMTY
1160 1170 1180 1190 1200
SPNAVPIHPP AKPSGPTLRE RVQILQAEIQ KYTSRKVRHS PFYSPDAPFK
1210 1220 1230 1240 1250
GDFHRLARRL CGKSVGLVLG GGGARGIAQI GIIRAMQEAG IPIDIVGGTS
1260 1270 1280 1290 1300
IGAFIGALYA RHADFVPIVN AAKKFSGRMA SMWRFALDLT YPSASYTTGH
1310 1320 1330 1340 1350
EFNRGIFKAF GNTQIEDFWL DYYCNTTNIS KSRAEFHTSG YAWWYVRASM
1360 1370 1380 1390 1400
SLAGLLLPLC DEGSMLLDGG YVDNLTVSHM KSLGSDVIFA VDVGALDDNT
1410 1420 1430 1440 1450
PQAFGDSLSG MWAFFNRWNP FSSVANPPTL AEIQARLAYV SSVDALERAK
1460 1470 1480 1490 1500
TLPGCIYMRP PIEEYGTLDF GKFMEIYGVG YKYGQEFLAK LRERGGVLPI
1510 1520
GEEMGGKKGL RRTMAPRRAS I
Length:1,521
Mass (Da):167,339
Last modified:July 24, 2007 - v2
Checksum:i4120EA5A39BDAFF2
GO

Sequence cautioni

The sequence EAQ88144.1 differs from that shown. Reason: Frameshift at positions 1374 and 1405. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408032 Genomic DNA. Translation: EAQ88144.1. Frameshift.
RefSeqiXP_001223977.1. XM_001223976.1.

Genome annotation databases

GeneIDi4392000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408032 Genomic DNA. Translation: EAQ88144.1 . Frameshift.
RefSeqi XP_001223977.1. XM_001223976.1.

3D structure databases

ProteinModelPortali Q2H0D3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4392000.

Phylogenomic databases

InParanoidi Q2H0D3.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiNTE1_CHAGB
AccessioniPrimary (citable) accession number: Q2H0D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3