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Q2H0D3

- NTE1_CHAGB

UniProt

Q2H0D3 - NTE1_CHAGB

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1250 – 12501By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi670 – 789120cNMP 1Add
    BLAST
    Nucleotide bindingi837 – 957121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:CHGG_04763
    OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
    Taxonomic identifieri306901 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
    ProteomesiUP000001056: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15211521Lysophospholipase NTE1PRO_0000295316Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ2H0D3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050CytoplasmicBy similarityAdd
    BLAST
    Topological domaini72 – 9625LumenalBy similarityAdd
    BLAST
    Topological domaini118 – 15211404CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1217 – 1381165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1248 – 12525GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2H0D3-1 [UniParc]FASTAAdd to Basket

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    MDVVNSTARA AVTSATAVTA VTGTGDRHPN PLSSAVAAAS DVANAHGSSS     50
    WLGLFARVVL WLLQFVSMVL YYAIKLATIS VPTLLYTLFS TSLTVTMNAT 100
    TLMLIVAAMI GAISWVVRYR YLNMYSRLPP EPQRKEPDVD LFPDTHEEGI 150
    KSGLSNYFDE FLSAIKIFGY LERPVFHELT RSMQTRKLIA GESFNLEEEK 200
    GFCLVVDGLV EIFVKSSSYN RRYPHGPYFS PNSEAPSSDD EHPAPGQQRY 250
    QLLTEVRNGA PMSSLFSIMS LFTEDVPLRH ADEDNSEPGT TTHSGLFPNY 300
    PASADFRKSR VRMDSVPNTP QMDASASSSA NNLPGQLDRG LPHVPPISLD 350
    GTGFSKPQRP VPKRSNTTSA HPDIIARATV DTTVAIIPAS AFRRLIKIYP 400
    KATAHIVHVI LSRFQRVTLA TAYNYLGLTN EVLQIERQML KYTTQQLPNH 450
    LRGDALDRLK EKFKREVERM GEEDDVSKGI ALHNARAGRR RRSTATLRKE 500
    AALQAFSKQR NISSMSGSSL AIPNAGDLVT HLQQSRGGGN RAQSVAFTDG 550
    PSPHLDVERE AVSPLAQRTF DPFVTPRSIH VALEKRETLD EDNLFRESIL 600
    ECMFRSIGLT GSGGSNKDAD SNQASPRLIS FDQRRQKALY TNHAFGFMDG 650
    LDGSADGDTE SITSAGLSLP ASPNPQFLAQ EMRDEMEIVF FPKGSVLVEQ 700
    GERNPGLYYV VDGFLDICTQ EDAAASDVVH PTSRTSLHAM DSAQSIRSPQ 750
    RSPQPFAESM RSGNKVDDAE IKSKPNRRSV ALIKPGGLAG YVGTISSYRS 800
    FIEVVAKTDV YVGFLPLTSI ERIVDRYPIV LLTMAKRLTN LLPRLILHID 850
    FALEWLQVNA GQVIFHEGDE SEAIYIVLNG RLRLVEDRKD GGMNVKAEYG 900
    QGESIGELEV LTETSRSGTL HAIRDTELVK FPRTLFNSLA QEHPNITIKI 950
    SKIIASRMRA LIDDPSTMLG IKDSSGRSSI NKSSTTLNLR TVAVLPVSAG 1000
    VPVVEFSNRL LSALTEVGAP NGATSLNSAA VLNHLGKHAF NRMGKLKLSQ 1050
    YLADLEEKYG LVIYVADTNV NAPWTQTCVA QADCVLMVGL ADGSPEIGEY 1100
    ERFMLGMKST ARKILVLLHQ ERYSNSGLTR KWLKNRVWIN GGHFHVQMTY 1150
    SPNAVPIHPP AKPSGPTLRE RVQILQAEIQ KYTSRKVRHS PFYSPDAPFK 1200
    GDFHRLARRL CGKSVGLVLG GGGARGIAQI GIIRAMQEAG IPIDIVGGTS 1250
    IGAFIGALYA RHADFVPIVN AAKKFSGRMA SMWRFALDLT YPSASYTTGH 1300
    EFNRGIFKAF GNTQIEDFWL DYYCNTTNIS KSRAEFHTSG YAWWYVRASM 1350
    SLAGLLLPLC DEGSMLLDGG YVDNLTVSHM KSLGSDVIFA VDVGALDDNT 1400
    PQAFGDSLSG MWAFFNRWNP FSSVANPPTL AEIQARLAYV SSVDALERAK 1450
    TLPGCIYMRP PIEEYGTLDF GKFMEIYGVG YKYGQEFLAK LRERGGVLPI 1500
    GEEMGGKKGL RRTMAPRRAS I 1521
    Length:1,521
    Mass (Da):167,339
    Last modified:July 24, 2007 - v2
    Checksum:i4120EA5A39BDAFF2
    GO

    Sequence cautioni

    The sequence EAQ88144.1 differs from that shown. Reason: Frameshift at positions 1374 and 1405.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408032 Genomic DNA. Translation: EAQ88144.1. Frameshift.
    RefSeqiXP_001223977.1. XM_001223976.1.

    Genome annotation databases

    GeneIDi4392000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408032 Genomic DNA. Translation: EAQ88144.1 . Frameshift.
    RefSeqi XP_001223977.1. XM_001223976.1.

    3D structure databases

    ProteinModelPortali Q2H0D3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4392000.

    Phylogenomic databases

    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

    Entry informationi

    Entry nameiNTE1_CHAGB
    AccessioniPrimary (citable) accession number: Q2H0D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3