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Q2GYV9 (SSN3_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
ORF Names:CHGG_06845
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]
Taxonomic identifier306901 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Serine/threonine-protein kinase SSN3
PRO_0000312940

Regions

Domain106 – 455350Protein kinase
Nucleotide binding112 – 1209ATP By similarity
Compositional bias33 – 364Poly-Ser

Sites

Active site2381Proton acceptor By similarity
Binding site1361ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GYV9 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: E7A3857CC5158BAB

FASTA51256,984
        10         20         30         40         50         60 
MNNHYHPTGH RDAKTYAGDR PWPQWPGVPS GLSSSSGLLQ NRYYAPAGPF PLLPYFGELG 

        70         80         90        100        110        120 
AGPDTAMNQA KRQRAEVSYQ QPRPYPTGRG TGSMGYQSKV RVTDKYKVVG FISSGTYGRV 

       130        140        150        160        170        180 
YKALGRHGQP GEFAIKKFKP DKEGEQASYT GISQSAVREM ALCSELHHPN VIRLVEIILE 

       190        200        210        220        230        240 
DKCIFMVFEY AEHDLLQIIH HHTQQPRHPI PPNTIKSIMF QLLNGCQYLH TNWVLHRDLK 

       250        260        270        280        290        300 
PANIMVTSSG EVKIGDLGLA RLSYKPLHSL YGGDKVVVTI WYRAPELLLG SRHYTPAIDM 

       310        320        330        340        350        360 
WALGCIFAEL LSLRPIFKGE EAKMDSKKTV PFQRNQMQKI VDIMGLPTKE RWPLLTSTTE 

       370        380        390        400        410        420 
YSQLSTLQPP IHHGGHHGHH YQSQRQAAAA NAGVSHLEKW YYNTINQQTG GSGPGSGTSP 

       430        440        450        460        470        480 
LASLGAEGYK LLAGLLEYDP QRRLTAAAAL QHPFFSTGDP VSANCFEGLK TEYPHRRVSQ 

       490        500        510 
DDNDIRTSSL PGTKRSGLPD DSLRPGKRVK EG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408033 Genomic DNA. Translation: EAQ85592.1.
RefSeqXP_001224501.1. XM_001224500.1.

3D structure databases

ProteinModelPortalQ2GYV9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4394378.

Phylogenomic databases

OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_CHAGB
AccessionPrimary (citable) accession number: Q2GYV9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families