Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136ATPPROSITE-ProRule annotation1
Active sitei238Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi112 – 120ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:CHGG_06845
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
Proteomesi
  • UP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129401 – 512Serine/threonine-protein kinase SSN3Add BLAST512

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi306901.XP_001224501.1

Structurei

3D structure databases

ProteinModelPortaliQ2GYV9
SMRiQ2GYV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 455Protein kinasePROSITE-ProRule annotationAdd BLAST350

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 36Poly-Ser4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0666 Eukaryota
ENOG410XPPA LUCA
InParanoidiQ2GYV9
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q2GYV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNHYHPTGH RDAKTYAGDR PWPQWPGVPS GLSSSSGLLQ NRYYAPAGPF
60 70 80 90 100
PLLPYFGELG AGPDTAMNQA KRQRAEVSYQ QPRPYPTGRG TGSMGYQSKV
110 120 130 140 150
RVTDKYKVVG FISSGTYGRV YKALGRHGQP GEFAIKKFKP DKEGEQASYT
160 170 180 190 200
GISQSAVREM ALCSELHHPN VIRLVEIILE DKCIFMVFEY AEHDLLQIIH
210 220 230 240 250
HHTQQPRHPI PPNTIKSIMF QLLNGCQYLH TNWVLHRDLK PANIMVTSSG
260 270 280 290 300
EVKIGDLGLA RLSYKPLHSL YGGDKVVVTI WYRAPELLLG SRHYTPAIDM
310 320 330 340 350
WALGCIFAEL LSLRPIFKGE EAKMDSKKTV PFQRNQMQKI VDIMGLPTKE
360 370 380 390 400
RWPLLTSTTE YSQLSTLQPP IHHGGHHGHH YQSQRQAAAA NAGVSHLEKW
410 420 430 440 450
YYNTINQQTG GSGPGSGTSP LASLGAEGYK LLAGLLEYDP QRRLTAAAAL
460 470 480 490 500
QHPFFSTGDP VSANCFEGLK TEYPHRRVSQ DDNDIRTSSL PGTKRSGLPD
510
DSLRPGKRVK EG
Length:512
Mass (Da):56,984
Last modified:March 21, 2006 - v1
Checksum:iE7A3857CC5158BAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408033 Genomic DNA Translation: EAQ85592.1
RefSeqiXP_001224501.1, XM_001224500.1

Genome annotation databases

EnsemblFungiiEAQ85592; EAQ85592; CHGG_06845
GeneIDi4394378

Similar proteinsi

Entry informationi

Entry nameiSSN3_CHAGB
AccessioniPrimary (citable) accession number: Q2GYV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health