Serine/threonine-protein kinase SSN3 - Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase SSN3
EC=2.7.11.22
EC=2.7.11.23

Alternative name(s):
Cyclin-dependent kinase 8

Gene names

Name:	SSN3
Synonyms:	CDK8
ORF Names:	CHGG_06845

Organism

Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]

Taxonomic identifier

306901 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium ›

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Cofactor	Magnesium By similarity.
Subunit structure	Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Activator Kinase Repressor Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 512

512

Serine/threonine-protein kinase SSN3

PRO_0000312940

Regions

Domain

106 – 455

350

Protein kinase

Nucleotide binding

112 – 120

9

ATP By similarity

Compositional bias

33 – 36

4

Poly-Ser

Sites

Active site

238

1

Proton acceptor By similarity

Binding site

136

1

ATP By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q2GYV9 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: E7A3857CC5158BAB
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FASTA

512

56,984

        10         20         30         40         50         60 
MNNHYHPTGH RDAKTYAGDR PWPQWPGVPS GLSSSSGLLQ NRYYAPAGPF PLLPYFGELG 

        70         80         90        100        110        120 
AGPDTAMNQA KRQRAEVSYQ QPRPYPTGRG TGSMGYQSKV RVTDKYKVVG FISSGTYGRV 

       130        140        150        160        170        180 
YKALGRHGQP GEFAIKKFKP DKEGEQASYT GISQSAVREM ALCSELHHPN VIRLVEIILE 

       190        200        210        220        230        240 
DKCIFMVFEY AEHDLLQIIH HHTQQPRHPI PPNTIKSIMF QLLNGCQYLH TNWVLHRDLK 

       250        260        270        280        290        300 
PANIMVTSSG EVKIGDLGLA RLSYKPLHSL YGGDKVVVTI WYRAPELLLG SRHYTPAIDM 

       310        320        330        340        350        360 
WALGCIFAEL LSLRPIFKGE EAKMDSKKTV PFQRNQMQKI VDIMGLPTKE RWPLLTSTTE 

       370        380        390        400        410        420 
YSQLSTLQPP IHHGGHHGHH YQSQRQAAAA NAGVSHLEKW YYNTINQQTG GSGPGSGTSP 

       430        440        450        460        470        480 
LASLGAEGYK LLAGLLEYDP QRRLTAAAAL QHPFFSTGDP VSANCFEGLK TEYPHRRVSQ 

       490        500        510 
DDNDIRTSSL PGTKRSGLPD DSLRPGKRVK EG

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References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome."
The Broad Institute Genome Sequencing Platform
Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V.

Untereiner W.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408033 Genomic DNA. Translation: EAQ85592.1.
RefSeq	XP_001224501.1. XM_001224500.1.
3D structure databases
HSSP	HSSP built from PDB template 2CCH based on UniProtKB P24941.
ProteinModelPortal	Q2GYV9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4394378.
Phylogenomic databases
OrthoDB	EOG470XRW.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSN3_CHAGB

Accession

Primary (citable) accession number: Q2GYV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families