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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851By similarity
Active sitei385 – 3851By similarity
Active sitei447 – 4471By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CHGG_07037
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 519489LumenalSequence AnalysisAdd
BLAST
Transmembranei520 – 54021HelicalSequence AnalysisAdd
BLAST
Topological domaini541 – 643103CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 643613Pheromone-processing carboxypeptidase KEX1PRO_0000411912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2GYB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi529 – 5346Poly-Ala

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ2GYB7.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2GYB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPSWPSTGC WRHLPVVLAA LTLPWTATLA AAEKSAGDYF VHSLPGAPEG
60 70 80 90 100
PLVKMHAGHI EVTPETNGNL FFWHFQNKHI ANKQRTVIWL NGGPGCSSED
110 120 130 140 150
GALMEIGPYR LKDDKTLMYN DGAWNEFANV LFVDNPVGTG FSYVDTNAYV
160 170 180 190 200
RELDEMAEQF VIFMEKWYKL FPEYEHDDLY FAGESYAGQY IPYIAKHVLA
210 220 230 240 250
RNKEAGTKQW NLKGLLIGNG WISPPEQYEA YLQFAFEKGL VKKGSDIASK
260 270 280 290 300
LEVQLRICQK DLAVGESAVD HPECEKILQE ILKLTATRGK DNKLECYNMY
310 320 330 340 350
DVRLKDVYPS CGMNWPSDLA NVQPYLRRKD VVQALHVNPN KVTGWVECDG
360 370 380 390 400
RVGQNFNPVK SKPSIDLLPD ILSEVPVMLF SGAEDLICNH LGTEALISRM
410 420 430 440 450
AWNGGRGFEL SPGTWAPRRD WTFEGEDAGF WQEARNLTYV VFYNASHMVP
460 470 480 490 500
YDHPRRTRDM LDRFMGVDIS SIGGDPTDSR LDGEKGPETT VGGTAGNGNA
510 520 530 540 550
DQEAEKAKLS AAKWEAYRRS GEIVLVIVAV AAAAWGYFVW RERRKRRGYQ
560 570 580 590 600
GLASAENGAA GGVMGGNSGF RNTHGGRPRS DVEAGDFDET QLDSLHVRSP
610 620 630 640
VEGQEDARYS LGAVSDDDDE EEEGSAAGAK GKEKETGKAA ESS
Length:643
Mass (Da):71,275
Last modified:March 21, 2006 - v1
Checksum:i0BFAD91EF80932D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408033 Genomic DNA. Translation: EAQ85784.1.
RefSeqiXP_001224693.1. XM_001224692.1.

Genome annotation databases

GeneIDi4393231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408033 Genomic DNA. Translation: EAQ85784.1.
RefSeqiXP_001224693.1. XM_001224692.1.

3D structure databases

ProteinModelPortaliQ2GYB7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4393231.

Phylogenomic databases

InParanoidiQ2GYB7.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiKEX1_CHAGB
AccessioniPrimary (citable) accession number: Q2GYB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 21, 2006
Last modified: May 27, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.