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Q2GYB7

- KEX1_CHAGB

UniProt

Q2GYB7 - KEX1_CHAGB

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene
KEX1, CHGG_07037
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851 By similarity
Active sitei385 – 3851 By similarity
Active sitei447 – 4471 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CHGG_07037
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 519489Lumenal Reviewed predictionAdd
BLAST
Transmembranei520 – 54021Helical; Reviewed predictionAdd
BLAST
Topological domaini541 – 643103Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed predictionAdd
BLAST
Chaini31 – 643613Pheromone-processing carboxypeptidase KEX1PRO_0000411912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi436 – 4361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2GYB7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi529 – 5346Poly-Ala

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2GYB7-1 [UniParc]FASTAAdd to Basket

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MVPSWPSTGC WRHLPVVLAA LTLPWTATLA AAEKSAGDYF VHSLPGAPEG    50
PLVKMHAGHI EVTPETNGNL FFWHFQNKHI ANKQRTVIWL NGGPGCSSED 100
GALMEIGPYR LKDDKTLMYN DGAWNEFANV LFVDNPVGTG FSYVDTNAYV 150
RELDEMAEQF VIFMEKWYKL FPEYEHDDLY FAGESYAGQY IPYIAKHVLA 200
RNKEAGTKQW NLKGLLIGNG WISPPEQYEA YLQFAFEKGL VKKGSDIASK 250
LEVQLRICQK DLAVGESAVD HPECEKILQE ILKLTATRGK DNKLECYNMY 300
DVRLKDVYPS CGMNWPSDLA NVQPYLRRKD VVQALHVNPN KVTGWVECDG 350
RVGQNFNPVK SKPSIDLLPD ILSEVPVMLF SGAEDLICNH LGTEALISRM 400
AWNGGRGFEL SPGTWAPRRD WTFEGEDAGF WQEARNLTYV VFYNASHMVP 450
YDHPRRTRDM LDRFMGVDIS SIGGDPTDSR LDGEKGPETT VGGTAGNGNA 500
DQEAEKAKLS AAKWEAYRRS GEIVLVIVAV AAAAWGYFVW RERRKRRGYQ 550
GLASAENGAA GGVMGGNSGF RNTHGGRPRS DVEAGDFDET QLDSLHVRSP 600
VEGQEDARYS LGAVSDDDDE EEEGSAAGAK GKEKETGKAA ESS 643
Length:643
Mass (Da):71,275
Last modified:March 21, 2006 - v1
Checksum:i0BFAD91EF80932D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408033 Genomic DNA. Translation: EAQ85784.1.
RefSeqiXP_001224693.1. XM_001224692.1.

Genome annotation databases

GeneIDi4393231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408033 Genomic DNA. Translation: EAQ85784.1 .
RefSeqi XP_001224693.1. XM_001224692.1.

3D structure databases

ProteinModelPortali Q2GYB7.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4393231.

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiKEX1_CHAGB
AccessioniPrimary (citable) accession number: Q2GYB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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