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Q2GYB7 (KEX1_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:CHGG_07037
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]
Taxonomic identifier306901 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 643613Pheromone-processing carboxypeptidase KEX1
PRO_0000411912

Regions

Topological domain31 – 519489Lumenal Potential
Transmembrane520 – 54021Helical; Potential
Topological domain541 – 643103Cytoplasmic Potential
Compositional bias529 – 5346Poly-Ala

Sites

Active site1851 By similarity
Active site3851 By similarity
Active site4471 By similarity

Amino acid modifications

Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2GYB7 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 0BFAD91EF80932D3

FASTA64371,275
        10         20         30         40         50         60 
MVPSWPSTGC WRHLPVVLAA LTLPWTATLA AAEKSAGDYF VHSLPGAPEG PLVKMHAGHI 

        70         80         90        100        110        120 
EVTPETNGNL FFWHFQNKHI ANKQRTVIWL NGGPGCSSED GALMEIGPYR LKDDKTLMYN 

       130        140        150        160        170        180 
DGAWNEFANV LFVDNPVGTG FSYVDTNAYV RELDEMAEQF VIFMEKWYKL FPEYEHDDLY 

       190        200        210        220        230        240 
FAGESYAGQY IPYIAKHVLA RNKEAGTKQW NLKGLLIGNG WISPPEQYEA YLQFAFEKGL 

       250        260        270        280        290        300 
VKKGSDIASK LEVQLRICQK DLAVGESAVD HPECEKILQE ILKLTATRGK DNKLECYNMY 

       310        320        330        340        350        360 
DVRLKDVYPS CGMNWPSDLA NVQPYLRRKD VVQALHVNPN KVTGWVECDG RVGQNFNPVK 

       370        380        390        400        410        420 
SKPSIDLLPD ILSEVPVMLF SGAEDLICNH LGTEALISRM AWNGGRGFEL SPGTWAPRRD 

       430        440        450        460        470        480 
WTFEGEDAGF WQEARNLTYV VFYNASHMVP YDHPRRTRDM LDRFMGVDIS SIGGDPTDSR 

       490        500        510        520        530        540 
LDGEKGPETT VGGTAGNGNA DQEAEKAKLS AAKWEAYRRS GEIVLVIVAV AAAAWGYFVW 

       550        560        570        580        590        600 
RERRKRRGYQ GLASAENGAA GGVMGGNSGF RNTHGGRPRS DVEAGDFDET QLDSLHVRSP 

       610        620        630        640 
VEGQEDARYS LGAVSDDDDE EEEGSAAGAK GKEKETGKAA ESS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408033 Genomic DNA. Translation: EAQ85784.1.
RefSeqXP_001224693.1. XM_001224692.1.

3D structure databases

ProteinModelPortalQ2GYB7.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4393231.

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
ProtoNetSearch...

Entry information

Entry nameKEX1_CHAGB
AccessionPrimary (citable) accession number: Q2GYB7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries