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Q2GYB7

- KEX1_CHAGB

UniProt

Q2GYB7 - KEX1_CHAGB

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei185 – 1851By similarity
    Active sitei385 – 3851By similarity
    Active sitei447 – 4471By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:CHGG_07037
    OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
    Taxonomic identifieri306901 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
    ProteomesiUP000001056: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 643613Pheromone-processing carboxypeptidase KEX1PRO_0000411912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GYB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 519489LumenalSequence AnalysisAdd
    BLAST
    Topological domaini541 – 643103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei520 – 54021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi529 – 5346Poly-Ala

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2GYB7-1 [UniParc]FASTAAdd to Basket

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    MVPSWPSTGC WRHLPVVLAA LTLPWTATLA AAEKSAGDYF VHSLPGAPEG    50
    PLVKMHAGHI EVTPETNGNL FFWHFQNKHI ANKQRTVIWL NGGPGCSSED 100
    GALMEIGPYR LKDDKTLMYN DGAWNEFANV LFVDNPVGTG FSYVDTNAYV 150
    RELDEMAEQF VIFMEKWYKL FPEYEHDDLY FAGESYAGQY IPYIAKHVLA 200
    RNKEAGTKQW NLKGLLIGNG WISPPEQYEA YLQFAFEKGL VKKGSDIASK 250
    LEVQLRICQK DLAVGESAVD HPECEKILQE ILKLTATRGK DNKLECYNMY 300
    DVRLKDVYPS CGMNWPSDLA NVQPYLRRKD VVQALHVNPN KVTGWVECDG 350
    RVGQNFNPVK SKPSIDLLPD ILSEVPVMLF SGAEDLICNH LGTEALISRM 400
    AWNGGRGFEL SPGTWAPRRD WTFEGEDAGF WQEARNLTYV VFYNASHMVP 450
    YDHPRRTRDM LDRFMGVDIS SIGGDPTDSR LDGEKGPETT VGGTAGNGNA 500
    DQEAEKAKLS AAKWEAYRRS GEIVLVIVAV AAAAWGYFVW RERRKRRGYQ 550
    GLASAENGAA GGVMGGNSGF RNTHGGRPRS DVEAGDFDET QLDSLHVRSP 600
    VEGQEDARYS LGAVSDDDDE EEEGSAAGAK GKEKETGKAA ESS 643
    Length:643
    Mass (Da):71,275
    Last modified:March 21, 2006 - v1
    Checksum:i0BFAD91EF80932D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408033 Genomic DNA. Translation: EAQ85784.1.
    RefSeqiXP_001224693.1. XM_001224692.1.

    Genome annotation databases

    GeneIDi4393231.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408033 Genomic DNA. Translation: EAQ85784.1 .
    RefSeqi XP_001224693.1. XM_001224692.1.

    3D structure databases

    ProteinModelPortali Q2GYB7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4393231.

    Phylogenomic databases

    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

    Entry informationi

    Entry nameiKEX1_CHAGB
    AccessioniPrimary (citable) accession number: Q2GYB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3