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Q2GYA8

- MAP22_CHAGB

UniProt

Q2GYA8 - MAP22_CHAGB

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Protein
Methionine aminopeptidase 2-2
Gene
CHGG_07046
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei192 – 1921Substrate By similarity
Metal bindingi212 – 2121Divalent metal cation 1 By similarity
Metal bindingi223 – 2231Divalent metal cation 1 By similarity
Metal bindingi223 – 2231Divalent metal cation 2; catalytic By similarity
Metal bindingi292 – 2921Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei300 – 3001Substrate By similarity
Metal bindingi325 – 3251Divalent metal cation 2; catalytic By similarity
Metal bindingi420 – 4201Divalent metal cation 1 By similarity
Metal bindingi420 – 4201Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-2 (EC:3.4.11.18)
Short name:
MAP 2-2
Short name:
MetAP 2-2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:CHGG_07046
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Methionine aminopeptidase 2-2UniRule annotation
PRO_0000407604Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2GYA8.
SMRiQ2GYA8. Positions 72-439.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 617Poly-LysUniRule annotation
Compositional biasi64 – 674Poly-LysUniRule annotation

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GYA8-1 [UniParc]FASTAAdd to Basket

« Hide

MAAQAPPTDE LSKLSVEDAD NKPQPDASNG NLNHDEDDSE DDAEDASAPA    50
AGGAKKKKKR KPRKKKKNPT QQSDPPRVLI SQLFPDKQYP KGEEVEYLNE 100
NSYRTTNEEK RHLDNLKSEF LNDYRHAAEA HRQVRQWAAK NIKPGQSLTD 150
IANGIEDSVR ALVGHQGLEE GDALIAGMGF PTGLSINHCA AHYTPNAGNK 200
MILQQDDVMK IDFGVQVNGN IVDSAFTMAF NPRYDPLLEA VKAATNAGIK 250
EAGIDVRLGE IGGVIQEVME SYEVEIDGTT YPVKPIRNLN GHTILPYNIH 300
GGKSVPIVKS NDTTKMEEGD VFAIETFGST GGGHVIEDGE VSHYAKRTDA 350
PKVDLRLSSA KSLLSVINKN FGTLPWCRRY LDRLGQEKYL LGLNNLVSNG 400
IVEAYPPLVD KKGSYTAQFE HTILIRPTVK EVISRGDDF 439
Length:439
Mass (Da):48,244
Last modified:March 21, 2006 - v1
Checksum:iE1E54ED5023BDB67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408033 Genomic DNA. Translation: EAQ85793.1.
RefSeqiXP_001224702.1. XM_001224701.1.

Genome annotation databases

GeneIDi4393147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408033 Genomic DNA. Translation: EAQ85793.1 .
RefSeqi XP_001224702.1. XM_001224701.1.

3D structure databases

ProteinModelPortali Q2GYA8.
SMRi Q2GYA8. Positions 72-439.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4393147.

Phylogenomic databases

OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiMAP22_CHAGB
AccessioniPrimary (citable) accession number: Q2GYA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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