ID   SET1_CHAGB              Reviewed;        1076 AA.
AC   Q2GWF3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-4 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=COMPASS component SET1;
DE   AltName: Full=SET domain-containing protein 1;
GN   Name=SET1; ORFNames=CHGG_07701;
OS   Chaetomium globosum (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae;
OC   Chaetomium.
OX   NCBI_TaxID=38033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / IFO 6347 / NRRL 1970;
RA   Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M.,
RA   Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D.,
RA   Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W.;
RT   "Annotation of the Chaetomium globosum CBS 148.51 genome.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic component of the COMPASS (Set1C) complex that
CC       specifically mono-, di- and trimethylates histone H3 to form
CC       H3K4me1/2/3, which subsequently plays a role in telomere length
CC       maintenance and transcription elongation regulation (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine =
CC       S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
CC   -!- SUBUNIT: Component of the COMPASS (Set1C) complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Contains 1 post-SET domain.
CC   -!- SIMILARITY: Contains 1 SET domain.
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DR   EMBL; CH408033; EAQ86448.1; -; Genomic_DNA.
DR   RefSeq; XP_001225357.1; -.
DR   GeneID; 4393302; -.
DR   BRENDA; 2.1.1.43; 81575.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   InterPro; IPR012677; a_b_plait_nuc_bd.
DR   InterPro; IPR015722; MLL.
DR   InterPro; IPR003616; Post-SET_Zn_bd.
DR   InterPro; IPR001214; SET.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   PANTHER; PTHR22884:SF10; MLL; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosomal protein; Complete proteome;
KW   Methyltransferase; Nucleus; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1   1076       Histone-lysine N-methyltransferase, H3
FT                                lysine-4 specific.
FT                                /FTId=PRO_0000269769.
FT   DOMAIN      933   1055       SET.
FT   DOMAIN     1060   1076       Post-SET.
SQ   SEQUENCE   1076 AA;  121756 MW;  B10CF6093311D63D CRC64;
     MGTIWLISAA SDDQDDAPPS DPRLAKGGRL NYINVDFHLP KARLRHAPYN LKPYKYDPKT
     SCGPGPPTQV VVTGFNPLIA FSKVTAVFAS FGDIAESSNK MHPDTGSYLG FATFRYRDSK
     PSRSRPISIT GADAAKRAIR AMHGKRIEAN MVRVEYDAEG KKSSRMLVEV LQKGNETTPA
     LGEPRIPTGP KPKEVAPGPP PTAPKGPAAH RGGLMNVQGV WVPKPRPDSI IEVEPVIGHL
     KHDPYIFVGH EHVPVMPTTV AHMKRRLKTY MFEDIRADRT GYYIVFQDSG YGRAEAERCF
     RSADRTAFFT YTMVMVLHLY GTDGKASHAH ASDTRRRTRT PERKHVDEAR PHREHDRSRR
     DEERARRDEQ DRRRREDEAD LEEEKRQRAK NYDPVLEATD VVLRGMKEQL IKIIRTKIAA
     PALFNFLDPV NHLAKRRRLN LEDPHSARLP PIVLDEFEDR SPVSTPNSRA DPIERRTARL
     DVSALPRIRK VKNAGLNTRK HGFNDPFARN RPTARRTAFR SLHYRLRSDS EGESEDEAEN
     RTSLGRDTEE PESRPRSRMS SDDEGDKDDY ASWGPGDDDS MTEASFALGD GPGLAKKRKL
     DLQVETAIKR QKKTDEELFG VTIDRIGTEF PSREDSLEDV LPPGPGGGEE KDIGSSRLPT
     PLLQEGKAKK KAPAKTKRKS KKQLFEEREA LKRQQQEIFE REALQSEDVD EVIPTPEPES
     EPKKSKVEKE KEKEEKVEKP ALDENLYPSQ KVSVLELPHD FRLDVGSLEE LALGPNDQPD
     LDRLRKRFGR GKIDDPELWV WRRDRIRELN STDGSAKTPV RIEGYYVPNP TGCARAEGVK
     KILNSEKSKY LPHHIKVKKA REERQAQNGK NAKDSVLAAA EAARLAAESL VAKGNSRANR
     ANNRRFVADL NDQRKTLGQD SDVLRFNQLK KRKKPVKFAR SAIHNWGLYA MENIPKDDMI
     IEYVGEEVRQ QIAELRENRY LKSGIGSSYL FRIDDNTVID ATKKGGIARF INHSCMPNCT
     AKIIKVEGSK RIVIYALRDI AQNEELTYDY KFERELGSTD RIPCLCGTAA CKGFLN
//