Reviewed, UniProtKB/Swiss-Prot Q2GWF3 (SET1_CHAGB)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specific
    EC=2.1.1.43
Alternative name(s):
    COMPASS component SET1
    SET domain-containing protein 1

Gene names

Name:	SET1
ORF Names:	CHGG_07701

Organism

Chaetomium globosum (Soil fungus) [Complete proteome]

Taxonomic identifier

38033 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium

Protein attributes

Sequence length	1076 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subunit structure	Component of the COMPASS (Set1C) complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 post-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1076	1076	Histone-lysine N-methyltransferase, H3 lysine-4 specific		PRO_0000269769
Regions
	Domain	933 – 1055	123	SET
	Domain	1060 – 1076	17	Post-SET

Sequences

	Sequence		Length	Mass (Da)
	Q2GWF3-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: B10CF6093311D63D	FASTA	1,076	121,756
	10 20 30 40 50 60 MGTIWLISAA SDDQDDAPPS DPRLAKGGRL NYINVDFHLP KARLRHAPYN LKPYKYDPKT 70 80 90 100 110 120 SCGPGPPTQV VVTGFNPLIA FSKVTAVFAS FGDIAESSNK MHPDTGSYLG FATFRYRDSK 130 140 150 160 170 180 PSRSRPISIT GADAAKRAIR AMHGKRIEAN MVRVEYDAEG KKSSRMLVEV LQKGNETTPA 190 200 210 220 230 240 LGEPRIPTGP KPKEVAPGPP PTAPKGPAAH RGGLMNVQGV WVPKPRPDSI IEVEPVIGHL 250 260 270 280 290 300 KHDPYIFVGH EHVPVMPTTV AHMKRRLKTY MFEDIRADRT GYYIVFQDSG YGRAEAERCF 310 320 330 340 350 360 RSADRTAFFT YTMVMVLHLY GTDGKASHAH ASDTRRRTRT PERKHVDEAR PHREHDRSRR 370 380 390 400 410 420 DEERARRDEQ DRRRREDEAD LEEEKRQRAK NYDPVLEATD VVLRGMKEQL IKIIRTKIAA 430 440 450 460 470 480 PALFNFLDPV NHLAKRRRLN LEDPHSARLP PIVLDEFEDR SPVSTPNSRA DPIERRTARL 490 500 510 520 530 540 DVSALPRIRK VKNAGLNTRK HGFNDPFARN RPTARRTAFR SLHYRLRSDS EGESEDEAEN 550 560 570 580 590 600 RTSLGRDTEE PESRPRSRMS SDDEGDKDDY ASWGPGDDDS MTEASFALGD GPGLAKKRKL 610 620 630 640 650 660 DLQVETAIKR QKKTDEELFG VTIDRIGTEF PSREDSLEDV LPPGPGGGEE KDIGSSRLPT 670 680 690 700 710 720 PLLQEGKAKK KAPAKTKRKS KKQLFEEREA LKRQQQEIFE REALQSEDVD EVIPTPEPES 730 740 750 760 770 780 EPKKSKVEKE KEKEEKVEKP ALDENLYPSQ KVSVLELPHD FRLDVGSLEE LALGPNDQPD 790 800 810 820 830 840 LDRLRKRFGR GKIDDPELWV WRRDRIRELN STDGSAKTPV RIEGYYVPNP TGCARAEGVK 850 860 870 880 890 900 KILNSEKSKY LPHHIKVKKA REERQAQNGK NAKDSVLAAA EAARLAAESL VAKGNSRANR 910 920 930 940 950 960 ANNRRFVADL NDQRKTLGQD SDVLRFNQLK KRKKPVKFAR SAIHNWGLYA MENIPKDDMI 970 980 990 1000 1010 1020 IEYVGEEVRQ QIAELRENRY LKSGIGSSYL FRIDDNTVID ATKKGGIARF INHSCMPNCT 1030 1040 1050 1060 1070 AKIIKVEGSK RIVIYALRDI AQNEELTYDY KFERELGSTD RIPCLCGTAA CKGFLN

References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome." Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / IFO 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH408033 Genomic DNA. Translation: EAQ86448.1.
RefSeq	XP_001225357.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4393302.
Enzyme and pathway databases
BRENDA	2.1.1.43. 81575.
Family and domain databases
InterPro	IPR012677. a_b_plait_nuc_bd. IPR015722. MLL. IPR003616. Post-SET_Zn_bd. IPR001214. SET. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
PANTHER	PTHR22884:SF10. MLL. 1 hit.
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET1_CHAGB

Accession

Primary (citable) accession number: Q2GWF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)