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Q2GSJ7

- MAP21_CHAGB

UniProt

Q2GSJ7 - MAP21_CHAGB

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Protein
Methionine aminopeptidase 2-1
Gene
CHGG_09057
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901Substrate By similarity
Metal bindingi211 – 2111Divalent metal cation 1 By similarity
Metal bindingi222 – 2221Divalent metal cation 1 By similarity
Metal bindingi222 – 2221Divalent metal cation 2; catalytic By similarity
Metal bindingi291 – 2911Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei299 – 2991Substrate By similarity
Metal bindingi324 – 3241Divalent metal cation 2; catalytic By similarity
Metal bindingi420 – 4201Divalent metal cation 1 By similarity
Metal bindingi420 – 4201Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-1 (EC:3.4.11.18)
Short name:
MAP 2-1
Short name:
MetAP 2-1
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:CHGG_09057
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Methionine aminopeptidase 2-1UniRule annotation
PRO_0000407626Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2GSJ7.
SMRiQ2GSJ7. Positions 68-439.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2GSJ7-1 [UniParc]FASTAAdd to Basket

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MSGGESRSPD MSRAGDGCLG DGGDDEESDG DGGEVNPASA DAESTQKKRK    50
KRNKKKSKKK SKADSPGEQS SPPRIPLDKL FPSGNFPEGE VLEYQATART 100
TAAERRSNAR QHWEDDTFLR NYRKAAEIHR QTRRWVHETA KPGVSLYDIA 150
VGIEDSVRAL LDNAGLETGE ALKSGMGFPT GLCLNNQVAH YTPNPGQKPV 200
LLQEQDVLTV DFGVHINGWI VDSAFTTAFD PTYDNLLAAV KDATNTGVKT 250
AGIDVRISDV SAAIQEVMES YEVEIRGKTY RVKPIRNLSG HNIHQYRIHG 300
GKSIPFVKNR DQTKMEEGEV FAIETFGSTG RGYIVDDVGV YGYGLNHNAP 350
LNVPVALPSA KRLHKTIREN FGTIVFCRRY LERLNVEKYL AGMNCLVQQG 400
VVEEYGPLMD VKGSYSAQFE HTFLLRGTHK EVFSRGDDY 439
Length:439
Mass (Da):48,503
Last modified:March 21, 2006 - v1
Checksum:i5AB283245BF9BDB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408034 Genomic DNA. Translation: EAQ85043.1.
RefSeqiXP_001226984.1. XM_001226983.1.

Genome annotation databases

GeneIDi4395918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408034 Genomic DNA. Translation: EAQ85043.1 .
RefSeqi XP_001226984.1. XM_001226983.1.

3D structure databases

ProteinModelPortali Q2GSJ7.
SMRi Q2GSJ7. Positions 68-439.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4395918.

Phylogenomic databases

OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiMAP21_CHAGB
AccessioniPrimary (citable) accession number: Q2GSJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 21, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi