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Q2GSJ7

- MAP21_CHAGB

UniProt

Q2GSJ7 - MAP21_CHAGB

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Protein

Methionine aminopeptidase 2-1

Gene

CHGG_09057

Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901SubstrateUniRule annotation
Metal bindingi211 – 2111Divalent metal cation 1UniRule annotation
Metal bindingi222 – 2221Divalent metal cation 1UniRule annotation
Metal bindingi222 – 2221Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi291 – 2911Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei299 – 2991SubstrateUniRule annotation
Metal bindingi324 – 3241Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi420 – 4201Divalent metal cation 1UniRule annotation
Metal bindingi420 – 4201Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Protein family/group databases

MEROPSiM24.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-1UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2-1UniRule annotation
Short name:
MetAP 2-1UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:CHGG_09057
OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Taxonomic identifieri306901 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
ProteomesiUP000001056: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Methionine aminopeptidase 2-1PRO_0000407626Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2GSJ7.
SMRiQ2GSJ7. Positions 68-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiQ2GSJ7.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2GSJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGGESRSPD MSRAGDGCLG DGGDDEESDG DGGEVNPASA DAESTQKKRK
60 70 80 90 100
KRNKKKSKKK SKADSPGEQS SPPRIPLDKL FPSGNFPEGE VLEYQATART
110 120 130 140 150
TAAERRSNAR QHWEDDTFLR NYRKAAEIHR QTRRWVHETA KPGVSLYDIA
160 170 180 190 200
VGIEDSVRAL LDNAGLETGE ALKSGMGFPT GLCLNNQVAH YTPNPGQKPV
210 220 230 240 250
LLQEQDVLTV DFGVHINGWI VDSAFTTAFD PTYDNLLAAV KDATNTGVKT
260 270 280 290 300
AGIDVRISDV SAAIQEVMES YEVEIRGKTY RVKPIRNLSG HNIHQYRIHG
310 320 330 340 350
GKSIPFVKNR DQTKMEEGEV FAIETFGSTG RGYIVDDVGV YGYGLNHNAP
360 370 380 390 400
LNVPVALPSA KRLHKTIREN FGTIVFCRRY LERLNVEKYL AGMNCLVQQG
410 420 430
VVEEYGPLMD VKGSYSAQFE HTFLLRGTHK EVFSRGDDY
Length:439
Mass (Da):48,503
Last modified:March 21, 2006 - v1
Checksum:i5AB283245BF9BDB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408034 Genomic DNA. Translation: EAQ85043.1.
RefSeqiXP_001226984.1. XM_001226983.1.

Genome annotation databases

GeneIDi4395918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408034 Genomic DNA. Translation: EAQ85043.1 .
RefSeqi XP_001226984.1. XM_001226983.1.

3D structure databases

ProteinModelPortali Q2GSJ7.
SMRi Q2GSJ7. Positions 68-439.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M24.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4395918.

Phylogenomic databases

InParanoidi Q2GSJ7.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Entry informationi

Entry nameiMAP21_CHAGB
AccessioniPrimary (citable) accession number: Q2GSJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 21, 2006
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3