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Q2GS86

- TRMB_CHAGB

UniProt

Q2GS86 - TRMB_CHAGB

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
TRM8, CHGG_09168
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei189 – 1891S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei192 – 1921 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine, tRNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    Transfer RNA methyltransferase 8
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:TRM8
    ORF Names:CHGG_09168
    OrganismiChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
    Taxonomic identifieri306901 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeChaetomium
    ProteomesiUP000001056: Unassembled WGS sequence

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000370593Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with TRM82 By similarity.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GS86.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1352S-adenosyl-L-methionine binding By similarity
    Regioni169 – 1702S-adenosyl-L-methionine binding By similarity
    Regioni267 – 2693S-adenosyl-L-methionine binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG708W9T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2GS86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGDKIKKDK RQKREDYRAA MRKDDISELP RKKFYRQRAH ANPFSDHQLI    50
    YPPHPDQMDW SSLYPHYIVD EPTTTSPPPP PPVPEQTPSE PDLTPLRPKP 100
    LSKEVSVADI GCGFGGLLIA LAPTMPEALI LGLEIRVSVT HFVEDRIKAL 150
    RAQNQAAGLY RNVGVLRANT MKFLPNFFRK AQLEKVFICF PDPHFKIRKH 200
    KQRIVSTTLN SEYAYVVKPG GIVYTITDVL DLHEWMVQHF DAHPSFERVS 250
    EEEQEADPCV AIMRTETEEG KKVERHKGEK HVALFRRLED PAW 293
    Length:293
    Mass (Da):33,667
    Last modified:March 21, 2006 - v1
    Checksum:iB6250E938A788357
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408034 Genomic DNA. Translation: EAQ85154.1.
    RefSeqiXP_001227095.1. XM_001227094.1.

    Genome annotation databases

    GeneIDi4395245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408034 Genomic DNA. Translation: EAQ85154.1 .
    RefSeqi XP_001227095.1. XM_001227094.1.

    3D structure databases

    ProteinModelPortali Q2GS86.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4395245.

    Phylogenomic databases

    OrthoDBi EOG708W9T.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

    Entry informationi

    Entry nameiTRMB_CHAGB
    AccessioniPrimary (citable) accession number: Q2GS86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: March 21, 2006
    Last modified: June 11, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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