Q2GQG8 (KMO_CHAGB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 4
Kynurenine 3-hydroxylase

Gene names

Name:	BNA4
ORF Names:	CHGG_09786

Organism

Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [Complete proteome]

Taxonomic identifier

306901 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Chaetomiaceae › Chaetomium

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Mitochondrion
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Kynurenine 3-monooxygenase		PRO_0000361925

Sequences

	Sequence		Length	Mass (Da)
	Q2GQG8 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 703C8A8F0FD0DE5C	FASTA	479	53,914
	10 20 30 40 50 60 MEKKQKVVVV GAGPVGSLAA LYAANRGDDV EIYELRSDLR DPTTTPLNFT KSINLALSER 70 80 90 100 110 120 GINAMRHAGQ PKLIEHVMGA TIPMHGRMIH GKRANGDLFE ESQNYDVYGR SILAVDRGRL 130 140 150 160 170 180 NERLLDILEA MPNVTFFFNH KLTGADFRKN KAWFEVRDKT GAAQGQQSRE IEVKFDLMIG 190 200 210 220 230 240 TDGAHSAVRY HMMKYTRMDY EQVYIDTMWC EFQIQPKTVV PDAPLDSKFS ISPNHLHIWP 250 260 270 280 290 300 GKEFMFIAIP SDDGSFTCTL FAPATLYEHL ESDRTGSLVP PFFDKYFPGV TTLIPPTELI 310 320 330 340 350 360 DSFHRNPHLP LISIKCKPHH YGSSVVILGD AAHAMVPFYG QGMNAGLEDV RILFDILDKH 370 380 390 400 410 420 ARMDELSACA DRAVSREHAL AEYTAVRVPD AHAINDLALQ NYVEMRASVL SPVYRLRKFL 430 440 450 460 470 EEALSKYVPS LGWQTKYARV SFGNERYSEV VAKSEHQGKM LVRGIGILSC RVGRALHNE

References

[1]

"Annotation of the Chaetomium globosum CBS 148.51 genome." The Broad Institute Genome Sequencing Platform Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K., Pushparaj V. , DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Yandava C., Zeng Q., Alvarado L., Oleary S., Untereiner W. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408035 Genomic DNA. Translation: EAQ83382.1.
RefSeq	XP_001227713.1. XM_001227712.1.
3D structure databases
ProteinModelPortal	Q2GQG8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4397066.
Phylogenomic databases
OrthoDB	EOG4QG0P2.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_CHAGB

Accession

Primary (citable) accession number: Q2GQG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program