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Q2GLU6 (RUVC_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:APH_0018
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_1000002714

Sites

Metal binding71Magnesium By similarity
Metal binding681Magnesium By similarity
Metal binding1421Magnesium By similarity
Metal binding1451Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GLU6 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: FB25A28C63B97A44

FASTA16317,327
        10         20         30         40         50         60 
MLVFGLDPGL NYTGWAVVLK EPSGSLSLLD TGTICTTSCS DLNDKLFCIF SGLSAIIQKF 

        70         80         90        100        110        120 
SVSVASIENV FVNLNPKASM FLCYARAASL LACLSSNVKI FEYSPTKIKK CVFGNGRASK 

       130        140        150        160 
EQIAFVVRSS LGLSEDASFS SHASDAIAAA LCHIFSSGNR YGI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000235 Genomic DNA. Translation: ABD44169.1.
RefSeqYP_504655.1. NC_007797.1.

3D structure databases

ProteinModelPortalQ2GLU6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING212042.APH_0018.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD44169; ABD44169; APH_0018.
GeneID3930900.
KEGGaph:APH_0018.
PATRIC20948574. VBIAnaPha602_0016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012181.
KOK01159.
OMAILHMIKL.
OrthoDBEOG6RG044.
ProtClustDBCLSK747421.

Enzyme and pathway databases

BioCycAPHA212042:GHPM-18-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVC_ANAPZ
AccessionPrimary (citable) accession number: Q2GLU6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families