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Q2GLP6

- SYE1_ANAPZ

UniProt

Q2GLP6 - SYE1_ANAPZ

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Protein
Glutamate--tRNA ligase 1
Gene
gltX1, gltX-1, APH_0072
Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei239 – 2391ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPHA212042:GHPM-72-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1 (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase 1
Short name:
GluRS 1
Gene namesi
Name:gltX1
Synonyms:gltX-1
Ordered Locus Names:APH_0072
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
ProteomesiUP000001943: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Glutamate--tRNA ligase 1UniRule annotation
PRO_0000237337Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi212042.APH_0072.

Structurei

3D structure databases

ProteinModelPortaliQ2GLP6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi7 – 1711"HIGH" regionUniRule annotation
Add
BLAST
Motifi236 – 2405"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252721.
KOiK01885.
OMAiRIALFNW.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GLP6-1 [UniParc]FASTAAdd to Basket

« Hide

MITRFAPSPT GYMHVGNART ALICWLYARS KSGKFLLRID DTDASRSEHK    50
YIEGIKQDLD WLALDWDSCF QQSTRLERYQ EVFDLLLDQG VIYPCYETQE 100
ELDMKRSMML KMGLPPIYDR SALKMTEQEM QACSGRLPYF RLKIDQSREI 150
TWEDEVRGRV SFQAKNISDP IIKRTDGTYT YMFPSVVDDI DFAITHIIRG 200
EDHVSNTATQ ICIFDILKAK VPVFVHLPLV HFRDAKISKR VGSDDIEIRH 250
LRDIGMEPMA IKSYLARMGT SLPVEPQENH DVLVESFDIR TFNQAPIKFS 300
LDDISRLNSR IVQCLSFDKV KDRFVQQGLE CTEEFWYLIR DNVNTVEDVR 350
EWINICNSQI TTAIDDKDRT FISEAKALLP DTELDEEVCK AWLQRIKETS 400
NRSTRDVLLP LRLATTGVTT GPGLAQLLPF IGRAEVVRRL ECASKGHNAN 450
Length:450
Mass (Da):51,850
Last modified:March 21, 2006 - v1
Checksum:iBF90C31A9B4A4ACD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000235 Genomic DNA. Translation: ABD44338.1.
RefSeqiYP_504705.1. NC_007797.1.

Genome annotation databases

EnsemblBacteriaiABD44338; ABD44338; APH_0072.
GeneIDi3930848.
KEGGiaph:APH_0072.
PATRICi20948702. VBIAnaPha602_0078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000235 Genomic DNA. Translation: ABD44338.1 .
RefSeqi YP_504705.1. NC_007797.1.

3D structure databases

ProteinModelPortali Q2GLP6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212042.APH_0072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD44338 ; ABD44338 ; APH_0072 .
GeneIDi 3930848.
KEGGi aph:APH_0072.
PATRICi 20948702. VBIAnaPha602_0078.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252721.
KOi K01885.
OMAi RIALFNW.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci APHA212042:GHPM-72-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HZ.

Entry informationi

Entry nameiSYE1_ANAPZ
AccessioniPrimary (citable) accession number: Q2GLP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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