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Q2GLP6 (SYE1_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase 1

EC=6.1.1.17
Alternative name(s):
Glutamyl-tRNA synthetase 1
Short name=GluRS 1
Gene names
Name:gltX1
Synonyms:gltX-1
Ordered Locus Names:APH_0072
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP-Rule MF_00022

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP-Rule MF_00022

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00022

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00022.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamate-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tRNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Glutamate--tRNA ligase 1 HAMAP-Rule MF_00022
PRO_0000237337

Regions

Motif7 – 1711"HIGH" region HAMAP-Rule MF_00022
Motif236 – 2405"KMSKS" region HAMAP-Rule MF_00022

Sites

Binding site2391ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GLP6 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: BF90C31A9B4A4ACD

FASTA45051,850
        10         20         30         40         50         60 
MITRFAPSPT GYMHVGNART ALICWLYARS KSGKFLLRID DTDASRSEHK YIEGIKQDLD 

        70         80         90        100        110        120 
WLALDWDSCF QQSTRLERYQ EVFDLLLDQG VIYPCYETQE ELDMKRSMML KMGLPPIYDR 

       130        140        150        160        170        180 
SALKMTEQEM QACSGRLPYF RLKIDQSREI TWEDEVRGRV SFQAKNISDP IIKRTDGTYT 

       190        200        210        220        230        240 
YMFPSVVDDI DFAITHIIRG EDHVSNTATQ ICIFDILKAK VPVFVHLPLV HFRDAKISKR 

       250        260        270        280        290        300 
VGSDDIEIRH LRDIGMEPMA IKSYLARMGT SLPVEPQENH DVLVESFDIR TFNQAPIKFS 

       310        320        330        340        350        360 
LDDISRLNSR IVQCLSFDKV KDRFVQQGLE CTEEFWYLIR DNVNTVEDVR EWINICNSQI 

       370        380        390        400        410        420 
TTAIDDKDRT FISEAKALLP DTELDEEVCK AWLQRIKETS NRSTRDVLLP LRLATTGVTT 

       430        440        450 
GPGLAQLLPF IGRAEVVRRL ECASKGHNAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000235 Genomic DNA. Translation: ABD44338.1.
RefSeqYP_504705.1. NC_007797.1.

3D structure databases

ProteinModelPortalQ2GLP6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING212042.APH_0072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD44338; ABD44338; APH_0072.
GeneID3930848.
KEGGaph:APH_0072.
PATRIC20948702. VBIAnaPha602_0078.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000252721.
KOK01885.
OMAAGRLYPC.
OrthoDBEOG6DRPF7.
ProtClustDBPRK12558.

Enzyme and pathway databases

BioCycAPHA212042:GHPM-72-MONOMER.

Family and domain databases

Gene3D1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00022_B. Glu_tRNA_synth_B.
InterProIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF48163. SSF48163. 1 hit.
TIGRFAMsTIGR00464. gltX_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYE1_ANAPZ
AccessionPrimary (citable) accession number: Q2GLP6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 21, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries