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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei239ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Synonyms:gltX-1
Ordered Locus Names:APH_0072
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
Proteomesi
  • UP000001943 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002373371 – 450Glutamate--tRNA ligase 1Add BLAST450

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi212042.APH_0072

Structurei

3D structure databases

ProteinModelPortaliQ2GLP6
SMRiQ2GLP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 17"HIGH" regionUniRule annotationAdd BLAST11
Motifi236 – 240"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.3501 hit
3.40.50.6201 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q2GLP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITRFAPSPT GYMHVGNART ALICWLYARS KSGKFLLRID DTDASRSEHK
60 70 80 90 100
YIEGIKQDLD WLALDWDSCF QQSTRLERYQ EVFDLLLDQG VIYPCYETQE
110 120 130 140 150
ELDMKRSMML KMGLPPIYDR SALKMTEQEM QACSGRLPYF RLKIDQSREI
160 170 180 190 200
TWEDEVRGRV SFQAKNISDP IIKRTDGTYT YMFPSVVDDI DFAITHIIRG
210 220 230 240 250
EDHVSNTATQ ICIFDILKAK VPVFVHLPLV HFRDAKISKR VGSDDIEIRH
260 270 280 290 300
LRDIGMEPMA IKSYLARMGT SLPVEPQENH DVLVESFDIR TFNQAPIKFS
310 320 330 340 350
LDDISRLNSR IVQCLSFDKV KDRFVQQGLE CTEEFWYLIR DNVNTVEDVR
360 370 380 390 400
EWINICNSQI TTAIDDKDRT FISEAKALLP DTELDEEVCK AWLQRIKETS
410 420 430 440 450
NRSTRDVLLP LRLATTGVTT GPGLAQLLPF IGRAEVVRRL ECASKGHNAN
Length:450
Mass (Da):51,850
Last modified:March 21, 2006 - v1
Checksum:iBF90C31A9B4A4ACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA Translation: ABD44338.1
RefSeqiWP_011450231.1, NC_007797.1

Genome annotation databases

EnsemblBacteriaiABD44338; ABD44338; APH_0072
GeneIDi3930848
KEGGiaph:APH_0072

Similar proteinsi

Entry informationi

Entry nameiSYE1_ANAPZ
AccessioniPrimary (citable) accession number: Q2GLP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 21, 2006
Last modified: February 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome