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Protein

dCTP deaminase

Gene

dcd

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

  • dCTP deaminase activity Source: TIGR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:APH_0130
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
Proteomesi
  • UP000001943 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096771 – 185dCTP deaminaseAdd BLAST185

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_0130.

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Beta strandi19 – 21Combined sources3
Beta strandi27 – 32Combined sources6
Beta strandi34 – 37Combined sources4
Beta strandi40 – 52Combined sources13
Helixi67 – 69Combined sources3
Beta strandi70 – 80Combined sources11
Beta strandi84 – 95Combined sources12
Beta strandi100 – 105Combined sources6
Helixi108 – 111Combined sources4
Turni112 – 114Combined sources3
Beta strandi115 – 117Combined sources3
Beta strandi127 – 136Combined sources10
Beta strandi138 – 140Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi148 – 157Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KM3X-ray2.10A/B1-185[»]
ProteinModelPortaliQ2GLJ4.
SMRiQ2GLJ4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2GLJ4.

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228600.
KOiK01494.
OMAiEAGWEGH.
OrthoDBiPOG091H02A6.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2GLJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMPDHWIK ERALKDGMIS PFVDHKEGTG VLSYGLSSYG YDARLDNKFK
60 70 80 90 100
IFANTHSVVV DPKNFSQDSF VDREGDFCII PPNSFMLAKT VEYFNIPRDV
110 120 130 140 150
MVVCVGKSTY ARCGIVVNVT PLEPGWSGYV TLEFSNTSPL PVKVYAFEGA
160 170 180
CQFLFFSGKE RCSKSYDEAG GKYMGQSDVT LPIIS
Length:185
Mass (Da):20,591
Last modified:March 21, 2006 - v1
Checksum:iCEB4032A48EEE38F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43468.1.
RefSeqiWP_011450283.1. NC_007797.1.

Genome annotation databases

EnsemblBacteriaiABD43468; ABD43468; APH_0130.
GeneIDi3930370.
KEGGiaph:APH_0130.
PATRICi20948828. VBIAnaPha602_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43468.1.
RefSeqiWP_011450283.1. NC_007797.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KM3X-ray2.10A/B1-185[»]
ProteinModelPortaliQ2GLJ4.
SMRiQ2GLJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi212042.APH_0130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD43468; ABD43468; APH_0130.
GeneIDi3930370.
KEGGiaph:APH_0130.
PATRICi20948828. VBIAnaPha602_0139.

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228600.
KOiK01494.
OMAiEAGWEGH.
OrthoDBiPOG091H02A6.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Miscellaneous databases

EvolutionaryTraceiQ2GLJ4.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCD_ANAPZ
AccessioniPrimary (citable) accession number: Q2GLJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.