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Protein

Guanylate kinase

Gene

gmk

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPHA212042:GHPM-170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:APH_0170
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
ProteomesiUP000001943 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Guanylate kinasePRO_0000266285Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_0170.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125Combined sources
Helixi22 – 276Combined sources
Beta strandi34 – 363Combined sources
Beta strandi40 – 434Combined sources
Turni51 – 533Combined sources
Helixi60 – 689Combined sources
Beta strandi72 – 787Combined sources
Beta strandi81 – 866Combined sources
Helixi90 – 967Combined sources
Beta strandi99 – 1035Combined sources
Helixi106 – 11510Combined sources
Helixi117 – 1193Combined sources
Beta strandi120 – 1267Combined sources
Helixi130 – 1356Combined sources
Helixi152 – 1598Combined sources
Helixi160 – 1645Combined sources
Beta strandi165 – 1706Combined sources
Helixi174 – 18916Combined sources
Helixi192 – 1943Combined sources
Beta strandi195 – 1973Combined sources
Helixi198 – 2058Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LNCX-ray1.95A/B1-210[»]
ProteinModelPortaliQ2GLF7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2GLF7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 186181Guanylate kinase-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation
Contains 1 guanylate kinase-like domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiMSHYNEY.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GLF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSVGVILV LSSPSGCGKT TVANKLLEKQ KNNIVKSVSV TTRAARKGEK
60 70 80 90 100
EGKDYYFVDR EEFLRLCSNG EIIEHAEVFG NFYGVPRKNL EDNVDKGVST
110 120 130 140 150
LLVIDWQGAF KFMEMMREHV VSIFIMPPSM EELRRRLCGR RADDSEVVEA
160 170 180 190 200
RLKGAAFEIS HCEAYDYVIV NEDIEETADR ISNILRAEQM KTCRQVGLRE
210
LLESRFPIED
Length:210
Mass (Da):23,928
Last modified:March 21, 2006 - v1
Checksum:iA49B447B562D4E93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43557.1.
RefSeqiWP_011450318.1. NC_007797.1.
YP_504794.1. NC_007797.1.

Genome annotation databases

EnsemblBacteriaiABD43557; ABD43557; APH_0170.
KEGGiaph:APH_0170.
PATRICi20948908. VBIAnaPha602_0179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43557.1.
RefSeqiWP_011450318.1. NC_007797.1.
YP_504794.1. NC_007797.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LNCX-ray1.95A/B1-210[»]
ProteinModelPortaliQ2GLF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi212042.APH_0170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD43557; ABD43557; APH_0170.
KEGGiaph:APH_0170.
PATRICi20948908. VBIAnaPha602_0179.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiMSHYNEY.
OrthoDBiEOG6CP410.

Enzyme and pathway databases

BioCyciAPHA212042:GHPM-170-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ2GLF7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HZ.

Entry informationi

Entry nameiKGUA_ANAPZ
AccessioniPrimary (citable) accession number: Q2GLF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.