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Protein

Guanylate kinase

Gene

gmk

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:APH_0170
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
Proteomesi
  • UP000001943 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002662851 – 210Guanylate kinaseAdd BLAST210

Proteomic databases

PRIDEiQ2GLF7.

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_0170.

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi22 – 27Combined sources6
Beta strandi34 – 36Combined sources3
Beta strandi40 – 43Combined sources4
Turni51 – 53Combined sources3
Helixi60 – 68Combined sources9
Beta strandi72 – 78Combined sources7
Beta strandi81 – 86Combined sources6
Helixi90 – 96Combined sources7
Beta strandi99 – 103Combined sources5
Helixi106 – 115Combined sources10
Helixi117 – 119Combined sources3
Beta strandi120 – 126Combined sources7
Helixi130 – 135Combined sources6
Helixi152 – 159Combined sources8
Helixi160 – 164Combined sources5
Beta strandi165 – 170Combined sources6
Helixi174 – 189Combined sources16
Helixi192 – 194Combined sources3
Beta strandi195 – 197Combined sources3
Helixi198 – 205Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LNCX-ray1.95A/B1-210[»]
ProteinModelPortaliQ2GLF7.
SMRiQ2GLF7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2GLF7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 186Guanylate kinase-likeUniRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation
Contains 1 guanylate kinase-like domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
HOGENOMiHOG000037638.
KOiK00942.
OMAiDYCVIND.
OrthoDBiPOG091H01Q4.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GLF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSVGVILV LSSPSGCGKT TVANKLLEKQ KNNIVKSVSV TTRAARKGEK
60 70 80 90 100
EGKDYYFVDR EEFLRLCSNG EIIEHAEVFG NFYGVPRKNL EDNVDKGVST
110 120 130 140 150
LLVIDWQGAF KFMEMMREHV VSIFIMPPSM EELRRRLCGR RADDSEVVEA
160 170 180 190 200
RLKGAAFEIS HCEAYDYVIV NEDIEETADR ISNILRAEQM KTCRQVGLRE
210
LLESRFPIED
Length:210
Mass (Da):23,928
Last modified:March 21, 2006 - v1
Checksum:iA49B447B562D4E93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43557.1.

Genome annotation databases

EnsemblBacteriaiABD43557; ABD43557; APH_0170.
KEGGiaph:APH_0170.
PATRICi20948908. VBIAnaPha602_0179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43557.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LNCX-ray1.95A/B1-210[»]
ProteinModelPortaliQ2GLF7.
SMRiQ2GLF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi212042.APH_0170.

Proteomic databases

PRIDEiQ2GLF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD43557; ABD43557; APH_0170.
KEGGiaph:APH_0170.
PATRICi20948908. VBIAnaPha602_0179.

Phylogenomic databases

eggNOGiENOG4108UHA. Bacteria.
COG0194. LUCA.
HOGENOMiHOG000037638.
KOiK00942.
OMAiDYCVIND.
OrthoDBiPOG091H01Q4.

Miscellaneous databases

EvolutionaryTraceiQ2GLF7.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKGUA_ANAPZ
AccessioniPrimary (citable) accession number: Q2GLF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.