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Q2GL22 (Q2GL22_ANAPZ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ABD43384.1
Ordered Locus Names:APH_0317
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region247 – 2515ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2461 By similarity HAMAP MF_01815
Active site2761 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q2GL22 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 59664A513D90A2DA

FASTA31933,304
        10         20         30         40         50         60 
MKAVLCGVGS FLPHKAVTNE DLSLIVDTTD EWIFRRTGIK RRYLVSEGEA TSDMAVKAAE 

        70         80         90        100        110        120 
AALSDAGVSA EEVDLIVVAT STPDSTLPSC ATMVQGKLGC TKAFAFDMNA ACSGFVYAIS 

       130        140        150        160        170        180 
VVDSLIKTGQ VGVALLIGAE SMSKIVDWHD RSTCVLFGDG AGACVFKGDG KASNRGIVDT 

       190        200        210        220        230        240 
ALYTDGTLGD ILYTDGGVAS TCTAGHIRMK GTVLFEHAIL KLSSSVEGLL KKNAIGIDAI 

       250        260        270        280        290        300 
DWFIPHQANV RIVDLVAKRL GISQDKVVLG IGDHANTSAA SIPLAMSDAR RDGKLQEGQL 

       310 
VLLAAIGAGV TWGASLIRL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000235 Genomic DNA. Translation: ABD43384.1.
RefSeqYP_504929.1. NC_007797.1.

3D structure databases

ProteinModelPortalQ2GL22.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2GL22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3929967.
GenomeReviewsGene locus APH_0317 in contig CP000235_GR.
KEGGaph:APH_0317.
NMPDRfig|212042.5.peg.300.
PATRIC20949218. VBIAnaPha602_0331.
TIGRAPH_0317.

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMATVAIHAN.
PhylomeDBQ2GL22.
ProtClustDBCLSK747371.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2GL22_ANAPZ
AccessionPrimary (citable) accession number: Q2GL22
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info