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Protein

Superoxide dismutase

Gene

sodB

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Iron; via tele nitrogenCombined sources
Metal bindingi80 – 801Iron; via tele nitrogenCombined sources
Metal bindingi165 – 1651IronCombined sources
Metal bindingi169 – 1691Iron; via tele nitrogenCombined sources

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: TIGR

GO - Biological processi

  1. removal of superoxide radicals Source: GOC
  2. superoxide metabolic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

IronCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciAPHA212042:GHPM-370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodBImported
Ordered Locus Names:APH_0371Imported
OrganismiAnaplasma phagocytophilum (strain HZ)Imported
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
ProteomesiUP000001943 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_0371.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JS4X-ray1.95A/B/C/D1-206[»]
ProteinModelPortaliQ2GKX4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2GKX4.

Family & Domainsi

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013584.
KOiK04564.
OMAiFWEVIAP.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GKX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFELSDLPYE GLEPYISSHL LDRHYNGHHK TYVDVLNKLV VGTEFEGLGN
60 70 80 90 100
ESLGDIVVKA HNSGSAGRAI FNNAAQIWNH DFYWQSMKPN GGGNPPEKLR
110 120 130 140 150
EMIEHSFGSV EGFNNAFTTS GLGQFGSGWV WLVYDEDAKA LKVVSTANAD
160 170 180 190 200
SPLLTQGQLP LATMDVWEHA YYLDYLNLRK KYIDVFLEHL LNWDFVLGRL

EDAGVL
Length:206
Mass (Da):23,167
Last modified:March 20, 2006 - v1
Checksum:iA7C3846EED519C5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43382.1.
RefSeqiYP_504977.1. NC_007797.1.

Genome annotation databases

EnsemblBacteriaiABD43382; ABD43382; APH_0371.
GeneIDi3929965.
KEGGiaph:APH_0371.
PATRICi20949348. VBIAnaPha602_0394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD43382.1.
RefSeqiYP_504977.1. NC_007797.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JS4X-ray1.95A/B/C/D1-206[»]
ProteinModelPortaliQ2GKX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi212042.APH_0371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD43382; ABD43382; APH_0371.
GeneIDi3929965.
KEGGiaph:APH_0371.
PATRICi20949348. VBIAnaPha602_0394.

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013584.
KOiK04564.
OMAiFWEVIAP.
OrthoDBiEOG63NMNT.

Enzyme and pathway databases

BioCyciAPHA212042:GHPM-370-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ2GKX4.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HZImported.
  2. "Crystal structure of Iron superoxide dismutase from Anaplasma phagocytophilum."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Edwards T.E., Staker B.L.
    Submitted (AUG-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH IRON.

Entry informationi

Entry nameiQ2GKX4_ANAPZ
AccessioniPrimary (citable) accession number: Q2GKX4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2006
Last sequence update: March 20, 2006
Last modified: March 31, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.