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Q2GKW5 (Q2GKW5_ANAPZ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191 EMBL ABD43712.1
Ordered Locus Names:APH_0380
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
Q2GKW5 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: E26A10D5ADE94BCD

FASTA32435,750
        10         20         30         40         50         60 
MHSNCNDVEV ILAQPRGFCA GVERAVAILD MVVDQYIASK EVYVLHEIVH NAYVVESFRK 

        70         80         90        100        110        120 
RNVKFVASLD EVPTGAVLVF SAHGVAKQVR AAAQERGLVV IDATCPLVTK VHLEIHRYNK 

       130        140        150        160        170        180 
NGYKIILIGH KGHREVEGSM GQIQSEVLLV QNVDDVYNLP VDAETKLAYV TQTTLSVDDT 

       190        200        210        220        230        240 
RVIVEALKTR FPDIVGPDLK DICYATQNRQ TAVKELASMV DVMLIMGGKN SSNTNRLLDL 

       250        260        270        280        290        300 
AKVRNPRSFL IGSYEDVDLS WFADTKKIGV TAGASAPAIL VEELLKYFSS KMNIKVSTMD 

       310        320 
GVRENIVFKL PNLNESSHSF SSDA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000235 Genomic DNA. Translation: ABD43712.1.
RefSeqYP_504986.1. NC_007797.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2GKW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3931091.
GenomeReviewsGene locus APH_0380 in contig CP000235_GR.
KEGGaph:APH_0380.
NMPDRfig|212042.5.peg.365.
PATRIC20949366. VBIAnaPha602_0403.
TIGRAPH_0380.

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAHNQGKRY.
PhylomeDBQ2GKW5.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2GKW5_ANAPZ
AccessionPrimary (citable) accession number: Q2GKW5
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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