Reviewed, UniProtKB/Swiss-Prot Q2GKG5 (PSD_ANAPZ)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	APH_0544

Organism

Anaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]

Taxonomic identifier

212042 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000262181
	Chain	181 – 227	47	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000262182
Sites
	Site	180 – 181	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	181	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2GKG5-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 3C2D525B22CC4CF7	FASTA	227	24,487
	10 20 30 40 50 60 MCFPNIHKQG YPFIAIAFVL TCIGFAFSFG LGLVFQIITV LCACFFRNPD RIVPVDDKLI 70 80 90 100 110 120 ISPADGLVTS VAEVESPIEA GKMVTRVSVF LSILNVHVNR APVSGSVKLV EHRPGRFSPA 130 140 150 160 170 180 CTDGSTSENE RVRSVIESTF GNHNIVIEQV AGVLARRIVC DLKVGDNVKL GSRMGIIRFG 190 200 210 220 SRVNVYVPAG VPVLVTEGHT LVGGETVIAD LDSERTAGYP RATFEKV

References

[1]

"Comparative genomics of emerging human ehrlichiosis agents." Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N. , Nelson W.C., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H. PLoS Genet. 2:208-222(2006) [PubMed: 16482227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000235 Genomic DNA. Translation: ABD43741.1.
RefSeq	YP_505136.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2GKG5.
Genome annotation databases
GeneID	3931063.
GenomeReviews	Gene locus APH_0544 in contig CP000235_GR.
KEGG	aph:APH_0544.
NMPDR	fig|212042.5.peg.535.
TIGR	APH_0544.
Phylogenomic databases
eggNOG	COG0688.
HOGENOM	HBG541103.
OMA	IFMSVFN.
Enzyme and pathway databases
BioCyc	APHA212042:APH_0544-MONOMER.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase_related. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_ANAPZ

Accession

Primary (citable) accession number: Q2GKG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 21, 2006
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)