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Q2GK85

- MDH_ANAPZ

UniProt

Q2GK85 - MDH_ANAPZ

Protein

Malate dehydrogenase

Gene

mdh

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381NADUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei93 – 931SubstrateUniRule annotation
    Binding sitei100 – 1001NADUniRule annotation
    Binding sitei125 – 1251SubstrateUniRule annotation
    Binding sitei156 – 1561SubstrateUniRule annotation
    Active sitei180 – 1801Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 186NADUniRule annotation
    Nucleotide bindingi123 – 1253NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: TIGR

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: TIGR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciAPHA212042:GHPM-629-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:APH_0629
    OrganismiAnaplasma phagocytophilum (strain HZ)
    Taxonomic identifieri212042 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
    ProteomesiUP000001943: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Malate dehydrogenasePRO_0000241941Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi212042.APH_0629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GK85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYAPSAFV.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2GK85-1 [UniParc]FASTAAdd to Basket

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    MRSHRSVKVS LVGAGNIGGT LAYMLGVAGI CQELVFVDVM DGVPRGKLLD    50
    IGHALAISGV DITAVGGSDY AAIEGSDAIV VTAGLPRKEG MSREDLLMAN 100
    AAVIKGVAEN IRKYSPDAFV IVVTNPLDAM VWYMHQCSGL PVNKVVGMAG 150
    VLDSARFSFF LAKHMSVSVS SVSSVVLGGH GDLMLPLLKY STVGGVSVSD 200
    LISCGRLSSE DVHAIIERTR KGGEEIVKLL KSGSAYYAPA ASCMNMLESY 250
    LFDKRCVIPC SVGLDGKYGV NGGLFVGVPA VIGKNGVEEV IEYVLSQEER 300
    EIFEKSVGLI SNSVKIISEQ K 321
    Length:321
    Mass (Da):33,835
    Last modified:March 21, 2006 - v1
    Checksum:iDA06315D62C004C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000235 Genomic DNA. Translation: ABD44326.1.
    RefSeqiWP_011450737.1. NC_007797.1.
    YP_505216.1. NC_007797.1.

    Genome annotation databases

    EnsemblBacteriaiABD44326; ABD44326; APH_0629.
    GeneIDi3930971.
    KEGGiaph:APH_0629.
    PATRICi20949932. VBIAnaPha602_0679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000235 Genomic DNA. Translation: ABD44326.1 .
    RefSeqi WP_011450737.1. NC_007797.1.
    YP_505216.1. NC_007797.1.

    3D structure databases

    ProteinModelPortali Q2GK85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212042.APH_0629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD44326 ; ABD44326 ; APH_0629 .
    GeneIDi 3930971.
    KEGGi aph:APH_0629.
    PATRICi 20949932. VBIAnaPha602_0679.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YAPSAFV.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci APHA212042:GHPM-629-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HZ.

    Entry informationi

    Entry nameiMDH_ANAPZ
    AccessioniPrimary (citable) accession number: Q2GK85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3