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Q2GK85 (MDH_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:APH_0629
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Malate dehydrogenase HAMAP-Rule MF_00487
PRO_0000241941

Regions

Nucleotide binding13 – 186NAD By similarity
Nucleotide binding123 – 1253NAD By similarity

Sites

Active site1801Proton acceptor By similarity
Binding site381NAD By similarity
Binding site871Substrate By similarity
Binding site931Substrate By similarity
Binding site1001NAD By similarity
Binding site1251Substrate By similarity
Binding site1561Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GK85 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: DA06315D62C004C8

FASTA32133,835
        10         20         30         40         50         60 
MRSHRSVKVS LVGAGNIGGT LAYMLGVAGI CQELVFVDVM DGVPRGKLLD IGHALAISGV 

        70         80         90        100        110        120 
DITAVGGSDY AAIEGSDAIV VTAGLPRKEG MSREDLLMAN AAVIKGVAEN IRKYSPDAFV 

       130        140        150        160        170        180 
IVVTNPLDAM VWYMHQCSGL PVNKVVGMAG VLDSARFSFF LAKHMSVSVS SVSSVVLGGH 

       190        200        210        220        230        240 
GDLMLPLLKY STVGGVSVSD LISCGRLSSE DVHAIIERTR KGGEEIVKLL KSGSAYYAPA 

       250        260        270        280        290        300 
ASCMNMLESY LFDKRCVIPC SVGLDGKYGV NGGLFVGVPA VIGKNGVEEV IEYVLSQEER 

       310        320 
EIFEKSVGLI SNSVKIISEQ K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000235 Genomic DNA. Translation: ABD44326.1.
RefSeqYP_505216.1. NC_007797.1.

3D structure databases

ProteinModelPortalQ2GK85.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING212042.APH_0629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD44326; ABD44326; APH_0629.
GeneID3930971.
KEGGaph:APH_0629.
PATRIC20949932. VBIAnaPha602_0679.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAYAPSAFV.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycAPHA212042:GHPM-629-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_ANAPZ
AccessionPrimary (citable) accession number: Q2GK85
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families