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Protein

Malate dehydrogenase

Gene

mdh

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18NADUniRule annotation6
Nucleotide bindingi123 – 125NADUniRule annotation3

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: TIGR

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • carboxylic acid metabolic process Source: InterPro
  • tricarboxylic acid cycle Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:APH_0629
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
Proteomesi
  • UP000001943 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419411 – 321Malate dehydrogenaseAdd BLAST321

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_0629.

Structurei

3D structure databases

ProteinModelPortaliQ2GK85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiLQTFIAM.
OrthoDBiPOG091H02N6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2GK85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSHRSVKVS LVGAGNIGGT LAYMLGVAGI CQELVFVDVM DGVPRGKLLD
60 70 80 90 100
IGHALAISGV DITAVGGSDY AAIEGSDAIV VTAGLPRKEG MSREDLLMAN
110 120 130 140 150
AAVIKGVAEN IRKYSPDAFV IVVTNPLDAM VWYMHQCSGL PVNKVVGMAG
160 170 180 190 200
VLDSARFSFF LAKHMSVSVS SVSSVVLGGH GDLMLPLLKY STVGGVSVSD
210 220 230 240 250
LISCGRLSSE DVHAIIERTR KGGEEIVKLL KSGSAYYAPA ASCMNMLESY
260 270 280 290 300
LFDKRCVIPC SVGLDGKYGV NGGLFVGVPA VIGKNGVEEV IEYVLSQEER
310 320
EIFEKSVGLI SNSVKIISEQ K
Length:321
Mass (Da):33,835
Last modified:March 21, 2006 - v1
Checksum:iDA06315D62C004C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD44326.1.
RefSeqiWP_011450737.1. NC_007797.1.

Genome annotation databases

EnsemblBacteriaiABD44326; ABD44326; APH_0629.
GeneIDi3930971.
KEGGiaph:APH_0629.
PATRICi20949932. VBIAnaPha602_0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD44326.1.
RefSeqiWP_011450737.1. NC_007797.1.

3D structure databases

ProteinModelPortaliQ2GK85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi212042.APH_0629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD44326; ABD44326; APH_0629.
GeneIDi3930971.
KEGGiaph:APH_0629.
PATRICi20949932. VBIAnaPha602_0679.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiLQTFIAM.
OrthoDBiPOG091H02N6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_ANAPZ
AccessioniPrimary (citable) accession number: Q2GK85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.