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Q2GK85

- MDH_ANAPZ

UniProt

Q2GK85 - MDH_ANAPZ

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381NADUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei100 – 1001NADUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Active sitei180 – 1801Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186NADUniRule annotation
Nucleotide bindingi123 – 1253NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: TIGR

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAPHA212042:GHPM-629-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:APH_0629
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
ProteomesiUP000001943: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Malate dehydrogenasePRO_0000241941Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_0629.

Structurei

3D structure databases

ProteinModelPortaliQ2GK85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2GK85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSHRSVKVS LVGAGNIGGT LAYMLGVAGI CQELVFVDVM DGVPRGKLLD
60 70 80 90 100
IGHALAISGV DITAVGGSDY AAIEGSDAIV VTAGLPRKEG MSREDLLMAN
110 120 130 140 150
AAVIKGVAEN IRKYSPDAFV IVVTNPLDAM VWYMHQCSGL PVNKVVGMAG
160 170 180 190 200
VLDSARFSFF LAKHMSVSVS SVSSVVLGGH GDLMLPLLKY STVGGVSVSD
210 220 230 240 250
LISCGRLSSE DVHAIIERTR KGGEEIVKLL KSGSAYYAPA ASCMNMLESY
260 270 280 290 300
LFDKRCVIPC SVGLDGKYGV NGGLFVGVPA VIGKNGVEEV IEYVLSQEER
310 320
EIFEKSVGLI SNSVKIISEQ K
Length:321
Mass (Da):33,835
Last modified:March 21, 2006 - v1
Checksum:iDA06315D62C004C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD44326.1.
RefSeqiWP_011450737.1. NC_007797.1.
YP_505216.1. NC_007797.1.

Genome annotation databases

EnsemblBacteriaiABD44326; ABD44326; APH_0629.
GeneIDi3930971.
KEGGiaph:APH_0629.
PATRICi20949932. VBIAnaPha602_0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD44326.1 .
RefSeqi WP_011450737.1. NC_007797.1.
YP_505216.1. NC_007797.1.

3D structure databases

ProteinModelPortali Q2GK85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212042.APH_0629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD44326 ; ABD44326 ; APH_0629 .
GeneIDi 3930971.
KEGGi aph:APH_0629.
PATRICi 20949932. VBIAnaPha602_0679.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci APHA212042:GHPM-629-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HZ.

Entry informationi

Entry nameiMDH_ANAPZ
AccessioniPrimary (citable) accession number: Q2GK85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3