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Q2GK20 (SYR_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:APH_0700
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000241977

Regions

Motif137 – 14711"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q2GK20 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: A5A0216ABAD6C597

FASTA58065,545
        10         20         30         40         50         60 
MLLDDKILDI FGFFRNAIEE RIRAVWSGDN IPESLFKRII VGPPAQPKHG DLYTNAALIL 

        70         80         90        100        110        120 
GKFDKKNPME LASTLCNAFE NIEGIESINV VAPGFINFHC VNSVWHGVVR NINKLGREYG 

       130        140        150        160        170        180 
RTDLGHNKKV NIEFVSANPT GPLHIGHARG AVFGDVLSNL LKWVGYDVIK EYYVNDAGSQ 

       190        200        210        220        230        240 
VKTLVSSVFL RYKEALGEEI TIGAGLYPGE YLKPIARDLV EKYGSDLLNA SDKDEIIRSF 

       250        260        270        280        290        300 
TLSSMLNLIK EDLALLGVEH DVFVSESDLQ NRNVIEECVK YLRERGIIYE GVLEKPKRED 

       310        320        330        340        350        360 
ELSEWQPRVQ MLFKSTEFGD DSDRALQKED GTWSYFAGDI GYHFHKISRG FDSMIMTLGF 

       370        380        390        400        410        420 
DHKGYVSRLK AAVAALSNGK ASIDIKLYNL VNFLENGTPV KMSKRKGEFL TVRDVIDEVG 

       430        440        450        460        470        480 
RDVARFMMLT RRNDVVLDFD FAKAREESKD SQIFYIQYAH ARIRSIVRRC PELLAIEKID 

       490        500        510        520        530        540 
FSCVITEQEL SLLRLLSRWP SVIKTSAENY EPHTIAFYLI EVAEAFHALW GCGNSDPSMR 

       550        560        570        580 
FIVEGDLHTT SARIYIAIAV SHVIASGLDI FSITPSEEMR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000235 Genomic DNA. Translation: ABD43701.1.
RefSeqYP_505281.1. NC_007797.1.

3D structure databases

ProteinModelPortalQ2GK20.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING212042.APH_0700.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD43701; ABD43701; APH_0700.
GeneID3930454.
KEGGaph:APH_0700.
PATRIC20950086. VBIAnaPha602_0753.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMARFIMLTR.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycAPHA212042:GHPM-700-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_ANAPZ
AccessionPrimary (citable) accession number: Q2GK20
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries