Q2GJY7 (FENR_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferredoxin--NADP reductase
Short name=FNR
Short name=Fd-NADP+ reductase
EC=1.18.1.2

Gene names

Ordered Locus Names:

APH_0734

Organism

Anaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]

Taxonomic identifier

212042 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_01685
Subunit structure	Homodimer By similarity. HAMAP MF_01685
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ferredoxin--NADP reductase HAMAP MF_01685		PRO_0000364783
Sites
	Binding site	36	1	FAD By similarity
	Binding site	44	1	FAD By similarity
	Binding site	49	1	FAD By similarity
	Binding site	89	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	123	1	FAD; via amide nitrogen By similarity
	Binding site	290	1	FAD By similarity
	Binding site	331	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2GJY7 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 6A9FF9FBB78DA593	FASTA	338	36,490
	10 20 30 40 50 60 MEYSSVFDVA IVGAGPVGLF TVFQAGMLGM NSCVIDALDI VGGQCAVLYP EKPIYDIPGY 70 80 90 100 110 120 PMITAQDLVN NLKKQAEPFA PVYIMGQFVE SISEGPDCFV LQTNKGTSVK CRAIIVAAGS 130 140 150 160 170 180 GGFGPNRPPL DGIMEYENKS VFYNVSQMAT FKNKKVVIAG GGDSAADWAV NLAEVADKLY 190 200 210 220 230 240 VIHRRKSFRC APNTLKKLEE LADEGRINVL IPYQLAGLDG ENGELRSVVV RNITTKEEIP 250 260 270 280 290 300 IGADFLLPFF GISANLGEIV NWGLGVEGFQ IPVEQSTCRT RRSKIYAVGD IAAYPGKIKL 310 320 330 ILVGFSEAAL ACQDIRAVLF PDTPLNFQYS TSKGIPTL

References

[1]

"Comparative genomics of emerging human ehrlichiosis agents." Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N. , Nelson W.C., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H. PLoS Genet. 2:208-222(2006) [PubMed: 16482227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HZ.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000235 Genomic DNA. Translation: ABD43586.1.
RefSeq	YP_505314.1. NC_007797.1.
3D structure databases
ProteinModelPortal	Q2GJY7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2GJY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3930132.
GenomeReviews	Gene locus APH_0734 in contig CP000235_GR.
KEGG	aph:APH_0734.
NMPDR	fig|212042.5.peg.715.
PATRIC	20950156. VBIAnaPha602_0787.
TIGR	APH_0734.
Phylogenomic databases
eggNOG	COG0492.
HOGENOM	HBG669726.
OMA	FQVFELG.
ProtClustDB	CLSK749573.
Enzyme and pathway databases
BioCyc	APHA212042:APH_0734-MONOMER.
Family and domain databases
HAMAP	MF_01685. FENR2. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR022890. Fd--NADP_Rdtase_type_2. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
KO	K00384.
PANTHER	PTHR22912:SF53. PTHR22912:SF53. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR_ANAPZ

Accession

Primary (citable) accession number: Q2GJY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program