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Q2GJV5 (PNP_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Polyribonucleotide nucleotidyltransferase
EC=2.7.7.8
Alternative name(s):
Polynucleotide phosphorylase
Short name=PNPase
Gene names
Name:pnp
Ordered Locus Names:APH_0767
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length838 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity. HAMAP MF_01595

Catalytic activity

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. HAMAP MF_01595

Subunit structure

Homotrimer. Organized into a structure (processome or RNA degradosome) containing a number of RNA-processing enzymes By similarity.

Subcellular location

Cytoplasm By similarity HAMAP MF_01595.

Sequence similarities

Belongs to the polyribonucleotide nucleotidyltransferase family.

Contains 1 KH domain.

Contains 1 S1 motif domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandRNA-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processRNA processing

Inferred from electronic annotation. Source: InterPro

mRNA catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3'-5'-exoribonuclease activity

Inferred from electronic annotation. Source: InterPro

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

polyribonucleotide nucleotidyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 838838Polyribonucleotide nucleotidyltransferase HAMAP MF_01595
PRO_0000329501

Regions

Domain561 – 62060KH
Domain630 – 69768S1 motif

Sequences

Sequence LengthMass (Da)Tools
Q2GJV5 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 27ABDC2FF220C83B

FASTA83889,762
        10         20         30         40         50         60 
MFDITRKCVE WGDRSLTIES GKIARQAGGA VVVDYGGTSV LATVVSQKSK EAVDFLPLTV 

        70         80         90        100        110        120 
QFLAKSYAVG KIPGGFFKRE GKPSDRETLI SRIIDRSIRP LFPSGFSDEV AVVCNLLSYD 

       130        140        150        160        170        180 
ASSPPETVAL IGASAALAIS GIPFHCPVAG ARIGYIRGEG RYILNPSADE LSVSALDMFY 

       190        200        210        220        230        240 
ARTDTSILMV ESEAHELTEA EMLGALQFGH EHCEEIIKVI GEFAEEARKC APAEFVPCDL 

       250        260        270        280        290        300 
STIIDSIGSD YKERFLVAYS EKEKKARVAK LDAVRASLTE DLRVKFLSES EGGSKYIAQD 

       310        320        330        340        350        360 
IVYAMKTFER SLVRERVLES KSRIDGRAYD QIRNIEIEVD LISKAHGSAL FTRGDTQALV 

       370        380        390        400        410        420 
ITALGTPQDE QIVDGFDGDK RERFLLHYNF PPYAVGEASA LRPPGRREIG HGKLAWRAIH 

       430        440        450        460        470        480 
PVLPSKADFP YTIRVVSEIT ESDGSSSMAT VCGASLALMD TGVPLKSSVA GIAMGLIKEG 

       490        500        510        520        530        540 
DRYAILSDIL GDEDYLGDMD FKVAGTREGI TALQMDMKVK GIDFAVLGTA LDQAKEGRFF 

       550        560        570        580        590        600 
IIEKMDRVIK ESRGAVREHV PRMESMLIDK GKIKNVIGAG GKNVREICEK TGAKIEISQD 

       610        620        630        640        650        660 
GTVMIYAVGR EAIESAKDMI TGIVSEPEVG KIYSGEVCEL AKYGAFVTFL GARKGLVHIS 

       670        680        690        700        710        720 
EIRNEHINAV ADVLAVGDKV KVLVIDMDKD HIQLSMRRID QETGDQVDCE LYAPQRRNGV 

       730        740        750        760        770        780 
AAGNTVGDSS VNGGGAGSVY VPRGDYGGAS AGRNGRGGGK RDGAAKSSSS AGNGGGRSSS 

       790        800        810        820        830 
STRRRHSAGS SGYSSDSSSG NTKSSSSESS GGTGGRGRNG ANGDVQNGPA APKKPRFF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000235 Genomic DNA. Translation: ABD44311.1.
RefSeqYP_505346.1. NC_007797.1.

3D structure databases

ProteinModelPortalQ2GJV5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2GJV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3930955.
GenomeReviewsGene locus APH_0767 in contig CP000235_GR.
KEGGaph:APH_0767.
NMPDRfig|212042.5.peg.742.
PATRIC20950226. VBIAnaPha602_0821.
TIGRAPH_0767.

Phylogenomic databases

eggNOGCOG1185.
HOGENOMHBG382411.
OMAYGETVVL.
PhylomeDBQ2GJV5.
ProtClustDBPRK11824.

Enzyme and pathway databases

BioCycAPHA212042:APH_0767-MONOMER.

Family and domain databases

HAMAPMF_01595. PNPase.
[Tree]
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH.
IPR004088. KH_type_1.
IPR018111. KH_type_1_subgr.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR012162. PNPase.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
G3DSA:1.10.10.400. PNPase_PH_RNA-bd_bac/org-type. 1 hit.
KOK00962.
PANTHERPTHR11252. PNPase. 1 hit.
PfamPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
SMARTSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF46915. 3_ExoRNase. 1 hit.
SSF55666. 3_ExoRNase. 2 hits.
SSF50249. Nucleic_acid_OB. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMsTIGR03591. Polynuc_phos. 1 hit.
PROSITEPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePNP_ANAPZ
AccessionPrimary (citable) accession number: Q2GJV5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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