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Q2GJV5

- PNP_ANAPZ

UniProt

Q2GJV5 - PNP_ANAPZ

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi494 – 4941MagnesiumUniRule annotation
    Metal bindingi500 – 5001MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. mRNA binding Source: TIGR
    4. polyribonucleotide nucleotidyltransferase activity Source: TIGR

    GO - Biological processi

    1. mRNA catabolic process Source: TIGR
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciAPHA212042:GHPM-767-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:APH_0767
    OrganismiAnaplasma phagocytophilum (strain HZ)
    Taxonomic identifieri212042 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
    ProteomesiUP000001943: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 838838Polyribonucleotide nucleotidyltransferasePRO_0000329501Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi212042.APH_0767.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GJV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini561 – 62060KHUniRule annotationAdd
    BLAST
    Domaini630 – 69768S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2GJV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFDITRKCVE WGDRSLTIES GKIARQAGGA VVVDYGGTSV LATVVSQKSK    50
    EAVDFLPLTV QFLAKSYAVG KIPGGFFKRE GKPSDRETLI SRIIDRSIRP 100
    LFPSGFSDEV AVVCNLLSYD ASSPPETVAL IGASAALAIS GIPFHCPVAG 150
    ARIGYIRGEG RYILNPSADE LSVSALDMFY ARTDTSILMV ESEAHELTEA 200
    EMLGALQFGH EHCEEIIKVI GEFAEEARKC APAEFVPCDL STIIDSIGSD 250
    YKERFLVAYS EKEKKARVAK LDAVRASLTE DLRVKFLSES EGGSKYIAQD 300
    IVYAMKTFER SLVRERVLES KSRIDGRAYD QIRNIEIEVD LISKAHGSAL 350
    FTRGDTQALV ITALGTPQDE QIVDGFDGDK RERFLLHYNF PPYAVGEASA 400
    LRPPGRREIG HGKLAWRAIH PVLPSKADFP YTIRVVSEIT ESDGSSSMAT 450
    VCGASLALMD TGVPLKSSVA GIAMGLIKEG DRYAILSDIL GDEDYLGDMD 500
    FKVAGTREGI TALQMDMKVK GIDFAVLGTA LDQAKEGRFF IIEKMDRVIK 550
    ESRGAVREHV PRMESMLIDK GKIKNVIGAG GKNVREICEK TGAKIEISQD 600
    GTVMIYAVGR EAIESAKDMI TGIVSEPEVG KIYSGEVCEL AKYGAFVTFL 650
    GARKGLVHIS EIRNEHINAV ADVLAVGDKV KVLVIDMDKD HIQLSMRRID 700
    QETGDQVDCE LYAPQRRNGV AAGNTVGDSS VNGGGAGSVY VPRGDYGGAS 750
    AGRNGRGGGK RDGAAKSSSS AGNGGGRSSS STRRRHSAGS SGYSSDSSSG 800
    NTKSSSSESS GGTGGRGRNG ANGDVQNGPA APKKPRFF 838
    Length:838
    Mass (Da):89,762
    Last modified:March 21, 2006 - v1
    Checksum:i27ABDC2FF220C83B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000235 Genomic DNA. Translation: ABD44311.1.
    RefSeqiYP_505346.1. NC_007797.1.

    Genome annotation databases

    EnsemblBacteriaiABD44311; ABD44311; APH_0767.
    GeneIDi3930955.
    KEGGiaph:APH_0767.
    PATRICi20950226. VBIAnaPha602_0821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000235 Genomic DNA. Translation: ABD44311.1 .
    RefSeqi YP_505346.1. NC_007797.1.

    3D structure databases

    ProteinModelPortali Q2GJV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212042.APH_0767.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD44311 ; ABD44311 ; APH_0767 .
    GeneIDi 3930955.
    KEGGi aph:APH_0767.
    PATRICi 20950226. VBIAnaPha602_0821.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci APHA212042:GHPM-767-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HZ.

    Entry informationi

    Entry nameiPNP_ANAPZ
    AccessioniPrimary (citable) accession number: Q2GJV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3