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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi494MagnesiumUniRule annotation1
Metal bindingi500MagnesiumUniRule annotation1

GO - Molecular functioni

  • 3'-5'-exoribonuclease activity Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • mRNA binding Source: TIGR
  • polyribonucleotide nucleotidyltransferase activity Source: TIGR

GO - Biological processi

  • mRNA catabolic process Source: TIGR
  • RNA processing Source: InterPro

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:APH_0767
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
Proteomesi
  • UP000001943 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295011 – 838Polyribonucleotide nucleotidyltransferaseAdd BLAST838

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_0767.

Structurei

3D structure databases

ProteinModelPortaliQ2GJV5.
SMRiQ2GJV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini561 – 620KHUniRule annotationAdd BLAST60
Domaini630 – 697S1 motifUniRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2GJV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDITRKCVE WGDRSLTIES GKIARQAGGA VVVDYGGTSV LATVVSQKSK
60 70 80 90 100
EAVDFLPLTV QFLAKSYAVG KIPGGFFKRE GKPSDRETLI SRIIDRSIRP
110 120 130 140 150
LFPSGFSDEV AVVCNLLSYD ASSPPETVAL IGASAALAIS GIPFHCPVAG
160 170 180 190 200
ARIGYIRGEG RYILNPSADE LSVSALDMFY ARTDTSILMV ESEAHELTEA
210 220 230 240 250
EMLGALQFGH EHCEEIIKVI GEFAEEARKC APAEFVPCDL STIIDSIGSD
260 270 280 290 300
YKERFLVAYS EKEKKARVAK LDAVRASLTE DLRVKFLSES EGGSKYIAQD
310 320 330 340 350
IVYAMKTFER SLVRERVLES KSRIDGRAYD QIRNIEIEVD LISKAHGSAL
360 370 380 390 400
FTRGDTQALV ITALGTPQDE QIVDGFDGDK RERFLLHYNF PPYAVGEASA
410 420 430 440 450
LRPPGRREIG HGKLAWRAIH PVLPSKADFP YTIRVVSEIT ESDGSSSMAT
460 470 480 490 500
VCGASLALMD TGVPLKSSVA GIAMGLIKEG DRYAILSDIL GDEDYLGDMD
510 520 530 540 550
FKVAGTREGI TALQMDMKVK GIDFAVLGTA LDQAKEGRFF IIEKMDRVIK
560 570 580 590 600
ESRGAVREHV PRMESMLIDK GKIKNVIGAG GKNVREICEK TGAKIEISQD
610 620 630 640 650
GTVMIYAVGR EAIESAKDMI TGIVSEPEVG KIYSGEVCEL AKYGAFVTFL
660 670 680 690 700
GARKGLVHIS EIRNEHINAV ADVLAVGDKV KVLVIDMDKD HIQLSMRRID
710 720 730 740 750
QETGDQVDCE LYAPQRRNGV AAGNTVGDSS VNGGGAGSVY VPRGDYGGAS
760 770 780 790 800
AGRNGRGGGK RDGAAKSSSS AGNGGGRSSS STRRRHSAGS SGYSSDSSSG
810 820 830
NTKSSSSESS GGTGGRGRNG ANGDVQNGPA APKKPRFF
Length:838
Mass (Da):89,762
Last modified:March 21, 2006 - v1
Checksum:i27ABDC2FF220C83B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA. Translation: ABD44311.1.
RefSeqiWP_011450867.1. NC_007797.1.

Genome annotation databases

EnsemblBacteriaiABD44311; ABD44311; APH_0767.
GeneIDi3930955.
KEGGiaph:APH_0767.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNP_ANAPZ
AccessioniPrimary (citable) accession number: Q2GJV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2006
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families