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Q2GJ82 (PDXH_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxine/pyridoxamine 5'-phosphate oxidase
EC=1.4.3.5
Alternative name(s):
PNP/PMP oxidase
Short name=PNPOx
Pyridoxal 5'-phosphate synthase
Gene names
Name:pdxH
Ordered Locus Names:APH_1008
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group ›

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) By similarity. HAMAP-Rule MF_01629

Catalytic activity

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2. HAMAP-Rule MF_01629

Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2. HAMAP-Rule MF_01629

Cofactor

Binds 1 FMN per subunit By similarity.

Pathway

Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1. HAMAP-Rule MF_01629

Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the pyridoxamine 5'-phosphate oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Pyridoxine/pyridoxamine 5'-phosphate oxidase HAMAP-Rule MF_01629
PRO_0000255852

Regions

Nucleotide binding69 – 702FMN By similarity
Nucleotide binding133 – 1342FMN By similarity
Region184 – 1863Substrate binding By similarity

Sites

Binding site541FMN By similarity
Binding site571FMN; via amide nitrogen By similarity
Binding site591Substrate By similarity
Binding site761FMN By similarity
Binding site1161Substrate By similarity
Binding site1201Substrate By similarity
Binding site1241Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GJ82 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 6FC10CDA3073AFEA

FASTA20624,007
        10         20         30         40         50         60 
MTINKEGLRV DACSGDPMSI FGLWYEEVLR VKSVREPSAM VLATCDSENR PSARVVLLKR 

        70         80         90        100        110        120 
YSDAGFEFYT NLESRKAREI ALNPCVSLVF DWRPIYKQVR VEGIAEFMDA SESDAYFASR 

       130        140        150        160        170        180 
SRESQIGAWC SRQSMILEDR DVLLSKIELM EREYEGREIP RPKFWGGIRV VPNVIEFWMD 

       190        200 
GKHRLHDRRQ YSKNIDGTWT SVYLYP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000235 Genomic DNA. Translation: ABD44041.1.
RefSeqYP_505569.1. NC_007797.1.

3D structure databases

ProteinModelPortalQ2GJ82.
ModBaseSearch...

Protein-protein interaction databases

STRING212042.APH_1008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD44041; ABD44041; APH_1008.
GeneID3930979.
KEGGaph:APH_1008.
PATRIC20950750. VBIAnaPha602_1076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0259.
HOGENOMHOG000242755.
KOK00275.
OMAERIEFWQ.
ProtClustDBCLSK747290.

Enzyme and pathway databases

BioCycAPHA212042:GHPM-1016-MONOMER.
UniPathwayUPA00190; UER00304.
UPA00190; UER00305.

Family and domain databases

Gene3D2.30.110.10. 1 hit.
HAMAPMF_01629. PdxH.
InterProIPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PANTHERPTHR10851. PTHR10851. 1 hit.
PfamPF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view]
PIRSFPIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMSSF50475. FMN_binding. 1 hit.
TIGRFAMsTIGR00558. pdxH. 1 hit.
PROSITEPS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDXH_ANAPZ
AccessionPrimary (citable) accession number: Q2GJ82
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 21, 2006
Last modified: May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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