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Q2GJ42 (SUCC_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5
Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta
Gene names
Name:sucC
Ordered Locus Names:APH_1052
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP MF_00558

Subunit structure

Heterotetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558
PRO_1000081999

Regions

Domain9 – 244236ATP-grasp
Nucleotide binding35 – 10874ATP By similarity

Sites

Metal binding1971Magnesium or manganese By similarity
Metal binding1991Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GJ42 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 4B924E1E284DD8F5

FASTA38841,378
        10         20         30         40         50         60 
MNVHEFQAKG ILSGFDVRVP KGVVVRSVEE VDSALGSLAA GIVAVKAQIH AGGRGKAGGV 

        70         80         90        100        110        120 
KIGKAREEVA DLVKSMLGSV LVTHQTSAAG QKVHAVYLEE GVSIKKEYYL GAVVDRKAGM 

       130        140        150        160        170        180 
VSVIFSSEGG MDIEEVAHSR PEMVVVVNVD PVYGFLDFHG RKLCYGLGLK KEQVVQITAM 

       190        200        210        220        230        240 
ARKVCRALME TDASQVEINP LVETTCGEFI ALDAKMTFDD NGLFRRPEIV KLTDPHEYSE 

       250        260        270        280        290        300 
EELEAAKYGL SYIKLDGNIG CMVNGAGLAM ATMDIVKYYG GEPANFLDVG GGASKDTVRE 

       310        320        330        340        350        360 
AFKIILRSGV DGILVNIFGG IMRCDVIAAG IIESAKEIGV SVPMVVRLSG TNYKIGKEML 

       370        380 
DASGLSIVTA ENLDEAARFV VDLVGKRG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000235 Genomic DNA. Translation: ABD44388.1.
RefSeqYP_505609.1. NC_007797.1.

3D structure databases

HSSPHSSP built from PDB template 2FP4 based on UniProtKB P53590.
ProteinModelPortalQ2GJ42.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2GJ42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3930725.
GenomeReviewsGene locus APH_1052 in contig CP000235_GR.
KEGGaph:APH_1052.
NMPDRfig|212042.5.peg.996.
PATRIC20950858. VBIAnaPha602_1128.
TIGRAPH_1052.

Phylogenomic databases

eggNOGCOG0045.
HOGENOMHBG315432.
OMALTQNDAR.
PhylomeDBQ2GJ42.
ProtClustDBPRK00696.

Enzyme and pathway databases

BioCycAPHA212042:APH_1052-MONOMER.

Family and domain databases

HAMAPMF_00558. Succ_CoA_beta.
[Tree]
InterProIPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
Gene3DG3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KOK01903.
PANTHERPTHR11815. CoA_lig_beta. 1 hit.
PfamPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF001554. SucCS_beta. 1 hit.
SUPFAMSSF52210. CoA_ligase. 1 hit.
TIGRFAMsTIGR01016. SucCoAbeta. 1 hit.
PROSITEPS50975. ATP_GRASP. False negative.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUCC_ANAPZ
AccessionPrimary (citable) accession number: Q2GJ42
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 21, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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