Reviewed, UniProtKB/Swiss-Prot Q2GJ42 (SUCC_ANAPZ)

Names and origin

Protein names

Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit beta
    EC=6.2.1.5
Alternative name(s):
    Succinyl-CoA synthetase subunit beta
      Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	APH_1052

Organism

Anaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]

Taxonomic identifier

212042 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558		PRO_1000081999
Regions
	Domain	9 – 244	236	ATP-grasp
	Nucleotide binding	35 – 108	74	ATP By similarity
Sites
	Metal binding	197	1	Magnesium or manganese By similarity
	Metal binding	199	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2GJ42-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 4B924E1E284DD8F5	FASTA	388	41,378
	10 20 30 40 50 60 MNVHEFQAKG ILSGFDVRVP KGVVVRSVEE VDSALGSLAA GIVAVKAQIH AGGRGKAGGV 70 80 90 100 110 120 KIGKAREEVA DLVKSMLGSV LVTHQTSAAG QKVHAVYLEE GVSIKKEYYL GAVVDRKAGM 130 140 150 160 170 180 VSVIFSSEGG MDIEEVAHSR PEMVVVVNVD PVYGFLDFHG RKLCYGLGLK KEQVVQITAM 190 200 210 220 230 240 ARKVCRALME TDASQVEINP LVETTCGEFI ALDAKMTFDD NGLFRRPEIV KLTDPHEYSE 250 260 270 280 290 300 EELEAAKYGL SYIKLDGNIG CMVNGAGLAM ATMDIVKYYG GEPANFLDVG GGASKDTVRE 310 320 330 340 350 360 AFKIILRSGV DGILVNIFGG IMRCDVIAAG IIESAKEIGV SVPMVVRLSG TNYKIGKEML 370 380 DASGLSIVTA ENLDEAARFV VDLVGKRG

References

[1]

"Comparative genomics of emerging human ehrlichiosis agents." Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N. , Nelson W.C., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H. PLoS Genet. 2:208-222(2006) [PubMed: 16482227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000235 Genomic DNA. Translation: ABD44388.1.
RefSeq	YP_505609.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3930725.
GenomeReviews	Gene locus APH_1052 in contig CP000235_GR.
KEGG	aph:APH_1052.
NMPDR	fig|212042.5.peg.996.
TIGR	APH_1052.
Phylogenomic databases
HOGENOM	Q2GJ42.
OMA	Q2GJ42. GLGTFKS.
Enzyme and pathway databases
BioCyc	APHA212042:APH_1052-MON.
Family and domain databases
HAMAP	MF_00558. [Tree]
InterPro	IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. False negative. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_ANAPZ

Accession

Primary (citable) accession number: Q2GJ42

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)