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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Anaplasma phagocytophilum (strain HZ)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi: lipoprotein biosynthesis (signal peptide cleavage)

This protein is involved in the pathway lipoprotein biosynthesis (signal peptide cleavage), which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoprotein biosynthesis (signal peptide cleavage) and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106UniRule annotation1
Active sitei133UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

UniPathwayiUPA00665

Protein family/group databases

MEROPSiA08.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Short name:
SPase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:APH_1160
OrganismiAnaplasma phagocytophilum (strain HZ)
Taxonomic identifieri212042 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasmaphagocytophilum group
Proteomesi
  • UP000001943 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei62 – 82HelicalUniRule annotationAdd BLAST21
Transmembranei126 – 146HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000769151 – 156Lipoprotein signal peptidaseAdd BLAST156

Interactioni

Protein-protein interaction databases

STRINGi212042.APH_1160

Structurei

3D structure databases

SMRiQ2GIV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105M02 Bacteria
COG0597 LUCA
HOGENOMiHOG000096992
KOiK03101
OMAiRYFFIAI
OrthoDBiPOG091H059F

Family and domain databases

HAMAPiMF_00161 LspA, 1 hit
InterProiView protein in InterPro
IPR001872 Peptidase_A8
PANTHERiPTHR33695 PTHR33695, 1 hit
PfamiView protein in Pfam
PF01252 Peptidase_A8, 1 hit
PRINTSiPR00781 LIPOSIGPTASE
TIGRFAMsiTIGR00077 lspA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2GIV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKSIIGIIV LHVVMALDQI SKLYMSKLYA AHGDITVFEY CNLIQLWNKG
60 70 80 90 100
ISFGLFSTLE NGNTVFMVLS AVIIAILSYT KIKTKSMSRS CCLSVIVGGA
110 120 130 140 150
LGNLMDRLRF GAVYDFIDLH IGDWHWPAFN LADLTITCGV IVFLAMELRK

RSQLNA
Length:156
Mass (Da):17,424
Last modified:March 21, 2006 - v1
Checksum:i27C92697B1A21F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000235 Genomic DNA Translation: ABD44336.1
RefSeqiWP_011451207.1, NC_007797.1

Genome annotation databases

EnsemblBacteriaiABD44336; ABD44336; APH_1160
GeneIDi3930846
KEGGiaph:APH_1160

Similar proteinsi

Entry informationi

Entry nameiLSPA_ANAPZ
AccessioniPrimary (citable) accession number: Q2GIV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health