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Q2GIL5 (TRMD_ANAPZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA (guanine-N(1)-)-methyltransferase
EC=2.1.1.228
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene names
Name:trmD
Ordered Locus Names:APH_1267
OrganismAnaplasma phagocytophilum (strain HZ) [Complete proteome] [HAMAP]
Taxonomic identifier212042 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma › phagocytophilum group

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity. HAMAP MF_00605

Catalytic activity

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. HAMAP MF_00605

Subunit structure

Homodimer By similarity. HAMAP MF_00605

Subcellular location

Cytoplasm Potential HAMAP MF_00605.

Sequence similarities

Belongs to the RNA methyltransferase TrmD family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA (guanine-N1-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232tRNA (guanine-N(1)-)-methyltransferase HAMAP MF_00605
PRO_0000257389

Regions

Region132 – 1376S-adenosyl-L-methionine binding By similarity

Sites

Binding site1121S-adenosyl-L-methionine; via amide nitrogen By similarity

Secondary structure

1 ............................. 232
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q2GIL5 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 413D471EE118F339

FASTA23225,761
        10         20         30         40         50         60 
MIFNVLTIFP QMFPGPLGVS NLGSALKKGL WTLNVFDIRA FANNKHNTVD DTPYGGGPGM 

        70         80         90        100        110        120 
LLRADVLGRC IDEVLSLHPN TKLMFTSPRG VSFTQDIARQ TMNFDNITLL CGRFEGIDER 

       130        140        150        160        170        180 
VVDFYKLQEV SIGDYVLSGG ELAAMVIIDT CVRMVPGVIG NAESLKQESM EGSLEYPQYT 

       190        200        210        220        230 
RPASWKGMEV PEVLLTGNHG EIEKWRRNAS LSITAARRPD LLKDRYGEND VE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000235 Genomic DNA. Translation: ABD43497.1.
RefSeqYP_505786.1. NC_007797.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3KNUX-ray2.25A/B/C/D1-232[»]
ProteinModelPortalQ2GIL5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2GIL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3930029.
GenomeReviewsGene locus APH_1267 in contig CP000235_GR.
KEGGaph:APH_1267.
NMPDRfig|212042.5.peg.1214.
PATRIC20951324. VBIAnaPha602_1358.
TIGRAPH_1267.

Phylogenomic databases

eggNOGCOG0336.
HOGENOMHBG285805.
OMAVCGRFEG.
PhylomeDBQ2GIL5.
ProtClustDBPRK00026.

Enzyme and pathway databases

BioCycAPHA212042:APH_1267-MONOMER.

Family and domain databases

HAMAPMF_00605. TrmD.
[Tree]
InterProIPR016009. tRNA_m1G_MeTrfase.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
[Graphical view]
Gene3DG3DSA:1.10.1270.20. tRNA_m1G_MeTrfase_C. 1 hit.
KOK00554.
PANTHERPTHR10056. PTHR10056. 1 hit.
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFPIRSF000386. tRNA_mtase. 1 hit.
TIGRFAMsTIGR00088. TrmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRMD_ANAPZ
AccessionPrimary (citable) accession number: Q2GIL5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 21, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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