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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:ECH_0290
OrganismiEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Taxonomic identifieri205920 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000008320 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000187021 – 242Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST242

Interactioni

Protein-protein interaction databases

STRINGi205920.ECH_0290.

Structurei

Secondary structure

1242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi11 – 17Combined sources7
Beta strandi23 – 28Combined sources6
Beta strandi30 – 34Combined sources5
Turni35 – 38Combined sources4
Beta strandi39 – 42Combined sources4
Helixi46 – 63Combined sources18
Beta strandi68 – 73Combined sources6
Beta strandi75 – 82Combined sources8
Beta strandi84 – 86Combined sources3
Beta strandi88 – 96Combined sources9
Helixi99 – 105Combined sources7
Beta strandi112 – 122Combined sources11
Turni125 – 128Combined sources4
Helixi134 – 139Combined sources6
Helixi145 – 168Combined sources24
Beta strandi171 – 178Combined sources8
Beta strandi180 – 183Combined sources4
Turni199 – 201Combined sources3
Beta strandi202 – 206Combined sources5
Turni207 – 209Combined sources3
Helixi216 – 219Combined sources4
Helixi225 – 236Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KREX-ray1.80A1-242[»]
ProteinModelPortaliQ2GHH2.
SMRiQ2GHH2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2GHH2.

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPR. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiPOG091H02H7.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GHH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKEKIYEG KAKIIFATLN PLEVIQHFKD EITAFNNKKA AIIHEKGILN
60 70 80 90 100
NYISSFLMKK LIDKGIKTHF ISLLNQREQL VKKITIIPIE VVIRNLAAGN
110 120 130 140 150
FSKRFQIADG TPFKSPIIEF YYKNDELSDP MVSEGHILSF QWLTNQELEK
160 170 180 190 200
IKILSLKINN ILSELFFNVG IKLVDFKLEF GKLHNDEQSD LFLADEISPD
210 220 230 240
TCRLWDISTN KRLDKDRYRL NLGNVIEGYR EVAHKLNAIP NL
Length:242
Mass (Da):28,036
Last modified:March 21, 2006 - v1
Checksum:i12A85540BC1587E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000236 Genomic DNA. Translation: ABD45002.1.
RefSeqiWP_006011312.1. NC_007799.1.

Genome annotation databases

EnsemblBacteriaiABD45002; ABD45002; ECH_0290.
KEGGiech:ECH_0290.
PATRICi20576085. VBIEhrCha103583_0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000236 Genomic DNA. Translation: ABD45002.1.
RefSeqiWP_006011312.1. NC_007799.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KREX-ray1.80A1-242[»]
ProteinModelPortaliQ2GHH2.
SMRiQ2GHH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205920.ECH_0290.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD45002; ABD45002; ECH_0290.
KEGGiech:ECH_0290.
PATRICi20576085. VBIEhrCha103583_0244.

Phylogenomic databases

eggNOGiENOG4107QPR. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiPOG091H02H7.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Miscellaneous databases

EvolutionaryTraceiQ2GHH2.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUR7_EHRCR
AccessioniPrimary (citable) accession number: Q2GHH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.