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Q2GHE0

- KGUA_EHRCR

UniProt

Q2GHE0 - KGUA_EHRCR

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Protein
Guanylate kinase
Gene
gmk, ECH_0322
Organism
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP By similarity.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECHA205920:GJNR-322-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:ECH_0322
OrganismiEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Taxonomic identifieri205920 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000008320: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Guanylate kinaseUniRule annotation
PRO_0000266320Add
BLAST

Proteomic databases

PRIDEiQ2GHE0.

Interactioni

Protein-protein interaction databases

STRINGi205920.ECH_0322.

Structurei

3D structure databases

ProteinModelPortaliQ2GHE0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 188180Guanylate kinase-like
Add
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiDAVFSIS.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GHE0-1 [UniParc]FASTAAdd to Basket

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MNDSLKSRGI MLVISSPSGG GKTTISHLLI NELQNDLVRS ISVTTREPRD    50
GEINGKDYFF VTEPEFINLC NTNQMLEYAK VFGNYYGIPR KFVTDNIANG 100
VSVLFSIDWQ GAFKLIDIMR EHVVSIFILP PSMEELQRRL YNRSGESDVI 150
NKRLGEAAFE ISHCYRYDYV IVNHDIEQSV YQIKCIFTSE KLKTQRRVSL 200
KQFIDNCIR 209
Length:209
Mass (Da):24,089
Last modified:March 21, 2006 - v1
Checksum:iD0AA6D89026F0DAD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000236 Genomic DNA. Translation: ABD45409.1.
RefSeqiYP_507143.1. NC_007799.1.

Genome annotation databases

EnsemblBacteriaiABD45409; ABD45409; ECH_0322.
GeneIDi3928029.
KEGGiech:ECH_0322.
PATRICi20576147. VBIEhrCha103583_0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000236 Genomic DNA. Translation: ABD45409.1 .
RefSeqi YP_507143.1. NC_007799.1.

3D structure databases

ProteinModelPortali Q2GHE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205920.ECH_0322.

Proteomic databases

PRIDEi Q2GHE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD45409 ; ABD45409 ; ECH_0322 .
GeneIDi 3928029.
KEGGi ech:ECH_0322.
PATRICi 20576147. VBIEhrCha103583_0275.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037638.
KOi K00942.
OMAi DAVFSIS.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci ECHA205920:GJNR-322-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC CRL-10679 / Arkansas.

Entry informationi

Entry nameiKGUA_EHRCR
AccessioniPrimary (citable) accession number: Q2GHE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi