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Q2GHE0 (KGUA_EHRCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:ECH_0322
OrganismEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas) [Complete proteome] [HAMAP]
Taxonomic identifier205920 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Guanylate kinase HAMAP-Rule MF_00328
PRO_0000266320

Regions

Domain9 – 188180Guanylate kinase-like
Nucleotide binding16 – 238ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GHE0 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: D0AA6D89026F0DAD

FASTA20924,089
        10         20         30         40         50         60 
MNDSLKSRGI MLVISSPSGG GKTTISHLLI NELQNDLVRS ISVTTREPRD GEINGKDYFF 

        70         80         90        100        110        120 
VTEPEFINLC NTNQMLEYAK VFGNYYGIPR KFVTDNIANG VSVLFSIDWQ GAFKLIDIMR 

       130        140        150        160        170        180 
EHVVSIFILP PSMEELQRRL YNRSGESDVI NKRLGEAAFE ISHCYRYDYV IVNHDIEQSV 

       190        200 
YQIKCIFTSE KLKTQRRVSL KQFIDNCIR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000236 Genomic DNA. Translation: ABD45409.1.
RefSeqYP_507143.1. NC_007799.1.

3D structure databases

ProteinModelPortalQ2GHE0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205920.ECH_0322.

Proteomic databases

PRIDEQ2GHE0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD45409; ABD45409; ECH_0322.
GeneID3928029.
KEGGech:ECH_0322.
PATRIC20576147. VBIEhrCha103583_0275.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037638.
KOK00942.
OMAILEIDFQ.
OrthoDBEOG6CP410.
ProtClustDBPRK00300.

Enzyme and pathway databases

BioCycECHA205920:GJNR-322-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_EHRCR
AccessionPrimary (citable) accession number: Q2GHE0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families