Malate dehydrogenase - Ehrlichia chaffeensis (strain Arkansas)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Malate dehydrogenase
EC=1.1.1.37

Gene names

Name:	mdh
Ordered Locus Names:	ECH_0641

Organism

Ehrlichia chaffeensis (strain Arkansas) [Complete proteome] [HAMAP]

Taxonomic identifier

205920 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia ›

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487
Catalytic activity	(S)-malate + NAD⁺ = oxaloacetate + NADH. HAMAP-Rule MF_00487
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 313

313

Malate dehydrogenase HAMAP-Rule MF_00487

PRO_0000241948

Regions

Nucleotide binding

11 – 16

6

NAD By similarity

Nucleotide binding

120 – 122

3

NAD By similarity

Sites

Active site

177

1

Proton acceptor By similarity

Binding site

35

1

NAD By similarity

Binding site

84

1

Substrate By similarity

Binding site

90

1

Substrate By similarity

Binding site

97

1

NAD By similarity

Binding site

122

1

Substrate By similarity

Binding site

153

1

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q2GGI2 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 63FA48F9074EF314
Show »

FASTA

313

33,688

        10         20         30         40         50         60 
MIKRKKIALI GAGSIGGMIA YLVRSRNLGD VVLLDVNGGI AKGKALDIAE SSPVAKHNGE 

        70         80         90        100        110        120 
ILGTNNYADI EGADAIIVTA GISRKPGMSR DDLINTNVHV IKEVAENIAK YAPNAFVVVV 

       130        140        150        160        170        180 
TNPLDIMVLA MHKYSHLPSN MVVGMAGVLD AARFSYFIAK ELNVSVDSVS SIVLGGHGDF 

       190        200        210        220        230        240 
MLPLVKYSSV GGISIADLVK MNLITQDRVN EIIEKTRKGG EEIVNLLKVG SAYYAPAESA 

       250        260        270        280        290        300 
LLMVDSYLND RRLMLSCSVY LKGEYGVHDL FVGVPVIIGK NGVEKVIELQ LTEEEKNVFN 

       310 
DSVMSIRKLV SNI

« Hide

References

[1]

"Comparative genomics of emerging human ehrlichiosis agents."
Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N.

Tettelin H.
PLoS Genet. 2:208-222(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Arkansas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000236 Genomic DNA. Translation: ABD44535.1.
RefSeq	YP_507451.1. NC_007799.1.
3D structure databases
ProteinModelPortal	Q2GGI2.
ModBase	Search...
Protein-protein interaction databases
STRING	205920.ECH_0641.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD44535; ABD44535; ECH_0641.
GeneID	3927483.
KEGG	ech:ECH_0641.
PATRIC	20576734. VBIEhrCha103583_0559.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0039.
HOGENOM	HOG000213794.
KO	K00024.
OMA	DVVDYAY.
ProtClustDB	PRK06223.
Enzyme and pathway databases
BioCyc	ECHA205920:GJNR-643-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
HAMAP	MF_00487. Malate_dehydrog_3.
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR011275. Malate_DH_type3. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11540. PTHR11540. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01763. MalateDH_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MDH_EHRCR

Accession

Primary (citable) accession number: Q2GGI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents