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Q2GGE6

- ASSY_EHRCR

UniProt

Q2GGE6 - ASSY_EHRCR

Protein

Argininosuccinate synthase

Gene

argG

Organism
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei85 – 851CitrullineUniRule annotation
    Binding sitei90 – 901CitrullineUniRule annotation
    Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171AspartateUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei121 – 1211CitrullineUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei176 – 1761CitrullineUniRule annotation
    Binding sitei185 – 1851CitrullineUniRule annotation
    Binding sitei261 – 2611CitrullineUniRule annotation
    Binding sitei273 – 2731CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 159ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECHA205920:GJNR-682-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:ECH_0680
    OrganismiEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
    Taxonomic identifieri205920 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000008320: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Argininosuccinate synthasePRO_0000263924Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi205920.ECH_0680.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GGE6.
    SMRiQ2GGE6. Positions 3-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiGIKSKFD.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2GGE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIVLAYSG GLDTSVILKW LQENYNCEVV VFTADLGQND DMSAIRQKAA    50
    ASNVKEIFIE DLKEEFVKDF VFPMFRANTV YEGYYLLGTS IARPLIAKRQ 100
    IEIAHLTGAD AVAHGATGKG NDQIRFEFGY YSCDPNIKVI APWRQWELTS 150
    RNSLIEYAKK HGIDVPLDKA SEPPYSIDAN LLHTSYEGKS LEDPYIEPDY 200
    TMLSKSVIPE LASDTPEYIE ISFKNGDPHA INNVPLSPAN LLQQLNIIGG 250
    RHGIGIIDIV ENRYIGIKSR GVYETPGGTI LLHAHRAIES ITLDREAAHL 300
    KDEIMPRYAK LIYNGYWWTT ERKMLQALID KSQDKVNGVV RLKLYKGSVM 350
    VVGRTSENSL YSHNLASFDS SGNYNHTDAE GFIKINSLRL RNS 393
    Length:393
    Mass (Da):44,168
    Last modified:March 21, 2006 - v1
    Checksum:i7A451DE6DC31D97A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000236 Genomic DNA. Translation: ABD44955.1.
    RefSeqiWP_011452756.1. NC_007799.1.
    YP_507487.1. NC_007799.1.

    Genome annotation databases

    EnsemblBacteriaiABD44955; ABD44955; ECH_0680.
    GeneIDi3927618.
    KEGGiech:ECH_0680.
    PATRICi20576810. VBIEhrCha103583_0594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000236 Genomic DNA. Translation: ABD44955.1 .
    RefSeqi WP_011452756.1. NC_007799.1.
    YP_507487.1. NC_007799.1.

    3D structure databases

    ProteinModelPortali Q2GGE6.
    SMRi Q2GGE6. Positions 3-391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205920.ECH_0680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD44955 ; ABD44955 ; ECH_0680 .
    GeneIDi 3927618.
    KEGGi ech:ECH_0680.
    PATRICi 20576810. VBIEhrCha103583_0594.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi GIKSKFD.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci ECHA205920:GJNR-682-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC CRL-10679 / Arkansas.

    Entry informationi

    Entry nameiASSY_EHRCR
    AccessioniPrimary (citable) accession number: Q2GGE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3