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Q2GGA4

- PNP_EHRCR

UniProt

Q2GGA4 - PNP_EHRCR

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi490 – 4901MagnesiumUniRule annotation
    Metal bindingi496 – 4961MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciECHA205920:GJNR-729-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:ECH_0726
    OrganismiEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
    Taxonomic identifieri205920 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000008320: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 796796Polyribonucleotide nucleotidyltransferasePRO_0000329631Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi205920.ECH_0726.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GGA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini557 – 61660KHUniRule annotationAdd
    BLAST
    Domaini626 – 69368S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiHGNFKSN.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2GGA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFNLIRRSAE WGGKTLVLES GKIARQASGA VMVSYAGTTV LATVVTGKTK    50
    EPVDFLPLTV QFVAKSYAVG KIPGGFLKRE GKPSDRETLI SRLIDRSIRP 100
    LFPAGFYDEI SIVCNLLSYD TVTPPEVTAL VGATAALSIS GVPFNGLVVG 150
    ARVGYLPSEG KYLLNASADE MLCSSLDLFL SGNEDSVLMV ESEASELSES 200
    QMLGAITFGH QHCQEVINLI KEFSHESGQT PIDFIPHDIS SLVSDIESSY 250
    KEDFSLAYSN TIKKERVLKL EELRGKVLSE VADKYSAGDV ECSDQDIVTA 300
    LKTFERSLVR SKIIDTSSRI DGRAFDEIRD IEIEVDVLPK AHGSALFTRG 350
    NTQALVVTAL GTPQDEQIVD DLDGDRRENF LLHYNFPPYA VGESAALRAP 400
    GRREIGHGKL AWRAIRYVLP EKSDFPYTIR VVSEITESDG SSSMATVCGA 450
    SLALMDTGVP IKSPVAGIAM GLIKEDDRFI ILSDILGDED HLGDMDFKVA 500
    GTAEGVTALQ MDMKISGIDI DIIEKALLQA KDGRMHILSK MNAVIQESRN 550
    RIKNHAPRIE SIFINKDKIR NVIGSGGKNI RDICEKTGAK IEIIQDGTVM 600
    IYAVNNEAVE YAKSMIMDIV TEPEIGKVFE GTVVEIMKFG AFVSFLGGKK 650
    GLVHISEIRN EHISSVGSVI SLNDKVKVLV IGIDREHIQL SMRRVDQESG 700
    EPIDGELYNI RKNSFSDDSC GSTGGSSFKE SYNPNSRHGS HEKKRSGGSS 750
    RSSRRNSNGP NYYREDLPSS NGFGNNNRSF SNSRNGHDVP RKPRFF 796
    Length:796
    Mass (Da):87,103
    Last modified:March 21, 2006 - v1
    Checksum:i6B861F1F681334E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000236 Genomic DNA. Translation: ABD45222.1.
    RefSeqiYP_507529.1. NC_007799.1.

    Genome annotation databases

    EnsemblBacteriaiABD45222; ABD45222; ECH_0726.
    GeneIDi3927271.
    KEGGiech:ECH_0726.
    PATRICi20576896. VBIEhrCha103583_0636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000236 Genomic DNA. Translation: ABD45222.1 .
    RefSeqi YP_507529.1. NC_007799.1.

    3D structure databases

    ProteinModelPortali Q2GGA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205920.ECH_0726.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD45222 ; ABD45222 ; ECH_0726 .
    GeneIDi 3927271.
    KEGGi ech:ECH_0726.
    PATRICi 20576896. VBIEhrCha103583_0636.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi HGNFKSN.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci ECHA205920:GJNR-729-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC CRL-10679 / Arkansas.

    Entry informationi

    Entry nameiPNP_EHRCR
    AccessioniPrimary (citable) accession number: Q2GGA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3