Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2GG43 (PYRF_EHRCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:ECH_0792
OrganismEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas) [Complete proteome] [HAMAP]
Taxonomic identifier205920 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000241857

Regions

Region60 – 6910Substrate binding By similarity

Sites

Active site621Proton donor By similarity
Binding site111Substrate By similarity
Binding site331Substrate By similarity
Binding site1171Substrate By similarity
Binding site1791Substrate By similarity
Binding site1871Substrate By similarity
Binding site2071Substrate; via amide nitrogen By similarity
Binding site2081Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GG43 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: E7B1BF62D2CE587D

FASTA23125,120
        10         20         30         40         50         60 
MFTNPIICAL DTHDINHALL LTKMLYGRVS MVKLGLEFFT AYGLSGVQAI ADCGVPIFLD 

        70         80         90        100        110        120 
LKLHDIPNTV SKAISVIASL NVAMLTIHVS GGREMMIRAM DSISGSVTKL VGVTVLTSMD 

       130        140        150        160        170        180 
DSDLKEIGVN ESPVQQVMLL SKLAREVGLY GIVCSAFEAK EVRNRYTEKD LKLIVPGIRF 

       190        200        210        220        230 
DSDCNDQKRV KSPKDAMLAG ANYLVIGRPI TMSSDPVQTV EDILLSISKC I 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000236 Genomic DNA. Translation: ABD45528.1.
RefSeqYP_507590.1. NC_007799.1.

3D structure databases

ProteinModelPortalQ2GG43.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205920.ECH_0792.

Proteomic databases

PRIDEQ2GG43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD45528; ABD45528; ECH_0792.
GeneID3927934.
KEGGech:ECH_0792.
PATRIC20577012. VBIEhrCha103583_0690.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226071.
KOK01591.
OMAHAKEPRE.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycECHA205920:GJNR-795-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_EHRCR
AccessionPrimary (citable) accession number: Q2GG43
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways