SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2GG41

- SYL_EHRCR

UniProt

Q2GG41 - SYL_EHRCR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leucine--tRNA ligase
Gene
leuS, ECH_0794
Organism
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei594 – 5941ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECHA205920:GJNR-797-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:ECH_0794
OrganismiEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Taxonomic identifieri205920 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000008320: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligaseUniRule annotation
PRO_0000334753Add
BLAST

Proteomic databases

PRIDEiQ2GG41.

Interactioni

Protein-protein interaction databases

STRINGi205920.ECH_0794.

Structurei

3D structure databases

ProteinModelPortaliQ2GG41.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 4411"HIGH" regionUniRule annotation
Add
BLAST
Motifi591 – 5955"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GG41-1 [UniParc]FASTAAdd to Basket

« Hide

MHYDFKKVEQ DIQGKWNFYT DAKQAQCYVL EMFPYPSGNI HMGHLRNYTI    50
GDVIARYKRA CGINVFHPIG WDAFGLPAEN AALSYNINPH TWTESNIDNM 100
RCQLKSIGLS YDWDKELATC DPSYYKHEQA FFLDFLKCGL AYRKESLVNW 150
DPVDQTVLAN EQVIDGRGWR SGAVVEKRKL FQWFLKITDF AEELLNDLQI 200
LDQWPEKVKL MQEKWIGKSQ GVVIDFEILG INKTLQVFTT CPHTLFGAAF 250
IAVSFDHPIL QYVNDSKVIQ LINDFDRKNL ISDVSSTIEK FGIDSGLVVK 300
HPLLNVNLPV YIVNFVLMDY ATGAIFGCPA HDQRDFEFAK KYSLPVKQVV 350
FPEVDVNLDK EAYVGSGIMK HSDFLDGMTV DEAKKAIVAK LTFLGVCKEI 400
TYYRMHDWGI SRQRYWGCPI PIIYCKKCGT VPVDKKDLPV TLPKDVDFTK 450
YGNPLDNHPT WKYVKCPSCG MDAERETDTF DTFFESSWYF AAFCGTSNGI 500
NKDVCNMLLP VNYYVGGVEH AVLHLLYSRF FCRALTKCGY FNIKEPFSNL 550
ITQGMVCHST YSDEQGNYLF PEEAKKMMEN GQHVTVGRAE KMSKSKKNVV 600
NLEYIIDKYG ADTARLFILS DTPPERDIEW LDDGIEGASR YLSKLWRVII 650
SYDKFNLNFN KENIIGDDVK YRRSVHKILS GITNDLDFCR LNCAVAKFRE 700
LSNIISEMIR TSVNCYVVSE AIYILIRVIE PFIPHIAEKL WENIGGKGML 750
WNQVWPKADS ELLVERNVTI VVQVNGKFVK ALTVANDIDD DQLKSMALEI 800
AKNRIGGNVV KDIYVIPKRV INIVAVKPS 829
Length:829
Mass (Da):94,868
Last modified:March 21, 2006 - v1
Checksum:i936299A00BE200DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000236 Genomic DNA. Translation: ABD45082.1.
RefSeqiWP_006011277.1. NC_007799.1.
YP_507592.1. NC_007799.1.

Genome annotation databases

EnsemblBacteriaiABD45082; ABD45082; ECH_0794.
GeneIDi3927180.
KEGGiech:ECH_0794.
PATRICi20577016. VBIEhrCha103583_0692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000236 Genomic DNA. Translation: ABD45082.1 .
RefSeqi WP_006011277.1. NC_007799.1.
YP_507592.1. NC_007799.1.

3D structure databases

ProteinModelPortali Q2GG41.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 205920.ECH_0794.

Proteomic databases

PRIDEi Q2GG41.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD45082 ; ABD45082 ; ECH_0794 .
GeneIDi 3927180.
KEGGi ech:ECH_0794.
PATRICi 20577016. VBIEhrCha103583_0692.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ECHA205920:GJNR-797-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC CRL-10679 / Arkansas.

Entry informationi

Entry nameiSYL_EHRCR
AccessioniPrimary (citable) accession number: Q2GG41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi