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Q2GG41 (SYL_EHRCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:ECH_0794
OrganismEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas) [Complete proteome] [HAMAP]
Taxonomic identifier205920 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Protein attributes

Sequence length829 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 829829Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334753

Regions

Motif34 – 4411"HIGH" region HAMAP-Rule MF_00049
Motif591 – 5955"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5941ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GG41 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 936299A00BE200DA

FASTA82994,868
        10         20         30         40         50         60 
MHYDFKKVEQ DIQGKWNFYT DAKQAQCYVL EMFPYPSGNI HMGHLRNYTI GDVIARYKRA 

        70         80         90        100        110        120 
CGINVFHPIG WDAFGLPAEN AALSYNINPH TWTESNIDNM RCQLKSIGLS YDWDKELATC 

       130        140        150        160        170        180 
DPSYYKHEQA FFLDFLKCGL AYRKESLVNW DPVDQTVLAN EQVIDGRGWR SGAVVEKRKL 

       190        200        210        220        230        240 
FQWFLKITDF AEELLNDLQI LDQWPEKVKL MQEKWIGKSQ GVVIDFEILG INKTLQVFTT 

       250        260        270        280        290        300 
CPHTLFGAAF IAVSFDHPIL QYVNDSKVIQ LINDFDRKNL ISDVSSTIEK FGIDSGLVVK 

       310        320        330        340        350        360 
HPLLNVNLPV YIVNFVLMDY ATGAIFGCPA HDQRDFEFAK KYSLPVKQVV FPEVDVNLDK 

       370        380        390        400        410        420 
EAYVGSGIMK HSDFLDGMTV DEAKKAIVAK LTFLGVCKEI TYYRMHDWGI SRQRYWGCPI 

       430        440        450        460        470        480 
PIIYCKKCGT VPVDKKDLPV TLPKDVDFTK YGNPLDNHPT WKYVKCPSCG MDAERETDTF 

       490        500        510        520        530        540 
DTFFESSWYF AAFCGTSNGI NKDVCNMLLP VNYYVGGVEH AVLHLLYSRF FCRALTKCGY 

       550        560        570        580        590        600 
FNIKEPFSNL ITQGMVCHST YSDEQGNYLF PEEAKKMMEN GQHVTVGRAE KMSKSKKNVV 

       610        620        630        640        650        660 
NLEYIIDKYG ADTARLFILS DTPPERDIEW LDDGIEGASR YLSKLWRVII SYDKFNLNFN 

       670        680        690        700        710        720 
KENIIGDDVK YRRSVHKILS GITNDLDFCR LNCAVAKFRE LSNIISEMIR TSVNCYVVSE 

       730        740        750        760        770        780 
AIYILIRVIE PFIPHIAEKL WENIGGKGML WNQVWPKADS ELLVERNVTI VVQVNGKFVK 

       790        800        810        820 
ALTVANDIDD DQLKSMALEI AKNRIGGNVV KDIYVIPKRV INIVAVKPS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000236 Genomic DNA. Translation: ABD45082.1.
RefSeqYP_507592.1. NC_007799.1.

3D structure databases

ProteinModelPortalQ2GG41.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING205920.ECH_0794.

Proteomic databases

PRIDEQ2GG41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD45082; ABD45082; ECH_0794.
GeneID3927180.
KEGGech:ECH_0794.
PATRIC20577016. VBIEhrCha103583_0692.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAPVIHCPK.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycECHA205920:GJNR-797-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_EHRCR
AccessionPrimary (citable) accession number: Q2GG41
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries