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Q2GG41

- SYL_EHRCR

UniProt

Q2GG41 - SYL_EHRCR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei594 – 5941ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECHA205920:GJNR-797-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:ECH_0794
    OrganismiEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
    Taxonomic identifieri205920 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000008320: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 829829Leucine--tRNA ligasePRO_0000334753Add
    BLAST

    Proteomic databases

    PRIDEiQ2GG41.

    Interactioni

    Protein-protein interaction databases

    STRINGi205920.ECH_0794.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GG41.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 4411"HIGH" regionAdd
    BLAST
    Motifi591 – 5955"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2GG41-1 [UniParc]FASTAAdd to Basket

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    MHYDFKKVEQ DIQGKWNFYT DAKQAQCYVL EMFPYPSGNI HMGHLRNYTI    50
    GDVIARYKRA CGINVFHPIG WDAFGLPAEN AALSYNINPH TWTESNIDNM 100
    RCQLKSIGLS YDWDKELATC DPSYYKHEQA FFLDFLKCGL AYRKESLVNW 150
    DPVDQTVLAN EQVIDGRGWR SGAVVEKRKL FQWFLKITDF AEELLNDLQI 200
    LDQWPEKVKL MQEKWIGKSQ GVVIDFEILG INKTLQVFTT CPHTLFGAAF 250
    IAVSFDHPIL QYVNDSKVIQ LINDFDRKNL ISDVSSTIEK FGIDSGLVVK 300
    HPLLNVNLPV YIVNFVLMDY ATGAIFGCPA HDQRDFEFAK KYSLPVKQVV 350
    FPEVDVNLDK EAYVGSGIMK HSDFLDGMTV DEAKKAIVAK LTFLGVCKEI 400
    TYYRMHDWGI SRQRYWGCPI PIIYCKKCGT VPVDKKDLPV TLPKDVDFTK 450
    YGNPLDNHPT WKYVKCPSCG MDAERETDTF DTFFESSWYF AAFCGTSNGI 500
    NKDVCNMLLP VNYYVGGVEH AVLHLLYSRF FCRALTKCGY FNIKEPFSNL 550
    ITQGMVCHST YSDEQGNYLF PEEAKKMMEN GQHVTVGRAE KMSKSKKNVV 600
    NLEYIIDKYG ADTARLFILS DTPPERDIEW LDDGIEGASR YLSKLWRVII 650
    SYDKFNLNFN KENIIGDDVK YRRSVHKILS GITNDLDFCR LNCAVAKFRE 700
    LSNIISEMIR TSVNCYVVSE AIYILIRVIE PFIPHIAEKL WENIGGKGML 750
    WNQVWPKADS ELLVERNVTI VVQVNGKFVK ALTVANDIDD DQLKSMALEI 800
    AKNRIGGNVV KDIYVIPKRV INIVAVKPS 829
    Length:829
    Mass (Da):94,868
    Last modified:March 21, 2006 - v1
    Checksum:i936299A00BE200DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000236 Genomic DNA. Translation: ABD45082.1.
    RefSeqiWP_006011277.1. NC_007799.1.
    YP_507592.1. NC_007799.1.

    Genome annotation databases

    EnsemblBacteriaiABD45082; ABD45082; ECH_0794.
    GeneIDi3927180.
    KEGGiech:ECH_0794.
    PATRICi20577016. VBIEhrCha103583_0692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000236 Genomic DNA. Translation: ABD45082.1 .
    RefSeqi WP_006011277.1. NC_007799.1.
    YP_507592.1. NC_007799.1.

    3D structure databases

    ProteinModelPortali Q2GG41.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 205920.ECH_0794.

    Proteomic databases

    PRIDEi Q2GG41.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD45082 ; ABD45082 ; ECH_0794 .
    GeneIDi 3927180.
    KEGGi ech:ECH_0794.
    PATRICi 20577016. VBIEhrCha103583_0692.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ECHA205920:GJNR-797-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC CRL-10679 / Arkansas.

    Entry informationi

    Entry nameiSYL_EHRCR
    AccessioniPrimary (citable) accession number: Q2GG41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3