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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 177ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:ECH_0809
OrganismiEhrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas)
Taxonomic identifieri205920 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000008320 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000486431 – 464Chromosomal replication initiator protein DnaAAdd BLAST464

Interactioni

Protein-protein interaction databases

STRINGi205920.ECH_0809.

Structurei

3D structure databases

ProteinModelPortaliQ2GG27.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235660.
KOiK02313.
OMAiQSKTRKR.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GG27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDGGTGLLG DCVKEKLQSD NQVIWKDIQV KLHKFYGNAI YDSWLSVLVY
60 70 80 90 100
INNEGGKVLL SAPTRFIKEW ILVHYLDQIL KYWQDEDQSV CSVDICVVNN
110 120 130 140 150
QDTNLLVNIK DQQDKEVRNN YDHLSSPLDP RFTFDNFVVG KPNELAFAAA
160 170 180 190 200
RRVAESNEPI SGSNPLFLYG GVGLGKTHLM HAIAWYIIKS SSKRKIAYLS
210 220 230 240 250
AEKFMYQYVT ALRSKDIMLF KEQFRSVDIL MVDDVQFISG KDSTQEEFFH
260 270 280 290 300
TFNALIDQNK QLVISADRSP SDLDGVEERI KSRLGWGLVA DINETTFELR
310 320 330 340 350
LGILQLKVEK MGINIPNKVL EFLAKNIKSN IRELEGALNK VVAHSSLVGC
360 370 380 390 400
SITLDSASDI LSDLLRANHK SVTLECIQRK VAEFFNIKIT DMYSTRRLRT
410 420 430 440 450
LARPRQVAMY LSKKLTQKSL PEIGKSFGGR DHATVIHAVK QIEKLIDTDS
460
KLRDDINLLT RMLR
Length:464
Mass (Da):52,768
Last modified:March 21, 2006 - v1
Checksum:iF677E7831AD10A1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000236 Genomic DNA. Translation: ABD44952.1.
RefSeqiWP_006009784.1. NC_007799.1.

Genome annotation databases

EnsemblBacteriaiABD44952; ABD44952; ECH_0809.
KEGGiech:ECH_0809.
PATRICi20577046. VBIEhrCha103583_0707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000236 Genomic DNA. Translation: ABD44952.1.
RefSeqiWP_006009784.1. NC_007799.1.

3D structure databases

ProteinModelPortaliQ2GG27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi205920.ECH_0809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD44952; ABD44952; ECH_0809.
KEGGiech:ECH_0809.
PATRICi20577046. VBIEhrCha103583_0707.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235660.
KOiK02313.
OMAiQSKTRKR.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_EHRCR
AccessioniPrimary (citable) accession number: Q2GG27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.