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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi489MagnesiumUniRule annotation1
Metal bindingi495MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciNSEN222891:G1G5M-50-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:NSE_0057
OrganismiNeorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
Proteomesi
  • UP000001942 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297321 – 757Polyribonucleotide nucleotidyltransferaseAdd BLAST757

Proteomic databases

PRIDEiQ2GEY8

Interactioni

Protein-protein interaction databases

STRINGi222891.NSE_0057

Structurei

3D structure databases

ProteinModelPortaliQ2GEY8
SMRiQ2GEY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini556 – 615KHUniRule annotationAdd BLAST60
Domaini632 – 700S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q2GEY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEIKESSME WEGKSLHIKT GEVARQAAGA ACVSYGGTVV LAVVTLQKDT
60 70 80 90 100
AASKKTSDLS GLALVTNFLA KSYALGRIPN GFFKREGKLS EREVLASRVV
110 120 130 140 150
DRAVRPLIEE NLVNEVNIVC KLLAHGNRKV LPEIPALIAA SAALQLSGIP
160 170 180 190 200
FSGPVIGVDV DMRGSEVTCN EIRETEGGLE LFVACTEESV VMVEAEASEA
210 220 230 240 250
SEEEVVNALS EALKSAKPVF SFINEFVKSV TTVKPIGVLY DNKELCEKVR
260 270 280 290 300
AACSGQLESV YNERISSKEK RHNKLGQIYT DTFAQLSDDG YAESEVLFFI
310 320 330 340 350
KKLEKEIVRK NVLEEGIRPD GRSLTEIRPI SIALDYLPGT HGSALFTRGG
360 370 380 390 400
TQSLVVATLG SYQDEQVMDD IDGERRESVL LHYNFLPYAV GEVGALRAPG
410 420 430 440 450
RREIGHGRLA LKAVKAVLPG KEVFPYTLRL VSEITESDGS SSMATVCGSS
460 470 480 490 500
LALMDTGVPI TKHVAGIAMG LITDGVRSAV LSDISGDEDM LGDMDFKVAG
510 520 530 540 550
TRNGIVALQM DMKVRGISIA TIRDALNQAL AGRLHILEKM EHVIAKPRES
560 570 580 590 600
LKDSAPKILC YKIDKDVVHK VIGSGGKTIR GISSDTSAKI DIDQNNYVYI
610 620 630 640 650
MADTEEALME AKTRVDMASG ASDSNVPQLK IGELYDGKIV SVVDFGLFVV
660 670 680 690 700
LPNKQEGLVH ISEISKNRVN DIRADYTEGQ AVTVRIKDIG SDGKIKLTMR
710 720 730 740 750
IDEDRVGSGG SSSSPKKRFG AHPRKNGKDN RSNNSERGFN ERSGSAEGSS

ISRKRFF
Length:757
Mass (Da):82,011
Last modified:March 21, 2006 - v1
Checksum:i850C9F558A54A16D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA Translation: ABD46123.1
RefSeqiWP_011451464.1, NC_007798.1

Genome annotation databases

EnsemblBacteriaiABD46123; ABD46123; NSE_0057
KEGGinse:NSE_0057

Similar proteinsi

Entry informationi

Entry nameiPNP_NEOSM
AccessioniPrimary (citable) accession number: Q2GEY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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