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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi489MagnesiumUniRule annotation1
Metal bindingi495MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:NSE_0057
OrganismiNeorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
Proteomesi
  • UP000001942 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003297321 – 757Polyribonucleotide nucleotidyltransferaseAdd BLAST757

Interactioni

Protein-protein interaction databases

STRINGi222891.NSE_0057.

Structurei

3D structure databases

ProteinModelPortaliQ2GEY8.
SMRiQ2GEY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini556 – 615KHUniRule annotationAdd BLAST60
Domaini632 – 700S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2GEY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEIKESSME WEGKSLHIKT GEVARQAAGA ACVSYGGTVV LAVVTLQKDT
60 70 80 90 100
AASKKTSDLS GLALVTNFLA KSYALGRIPN GFFKREGKLS EREVLASRVV
110 120 130 140 150
DRAVRPLIEE NLVNEVNIVC KLLAHGNRKV LPEIPALIAA SAALQLSGIP
160 170 180 190 200
FSGPVIGVDV DMRGSEVTCN EIRETEGGLE LFVACTEESV VMVEAEASEA
210 220 230 240 250
SEEEVVNALS EALKSAKPVF SFINEFVKSV TTVKPIGVLY DNKELCEKVR
260 270 280 290 300
AACSGQLESV YNERISSKEK RHNKLGQIYT DTFAQLSDDG YAESEVLFFI
310 320 330 340 350
KKLEKEIVRK NVLEEGIRPD GRSLTEIRPI SIALDYLPGT HGSALFTRGG
360 370 380 390 400
TQSLVVATLG SYQDEQVMDD IDGERRESVL LHYNFLPYAV GEVGALRAPG
410 420 430 440 450
RREIGHGRLA LKAVKAVLPG KEVFPYTLRL VSEITESDGS SSMATVCGSS
460 470 480 490 500
LALMDTGVPI TKHVAGIAMG LITDGVRSAV LSDISGDEDM LGDMDFKVAG
510 520 530 540 550
TRNGIVALQM DMKVRGISIA TIRDALNQAL AGRLHILEKM EHVIAKPRES
560 570 580 590 600
LKDSAPKILC YKIDKDVVHK VIGSGGKTIR GISSDTSAKI DIDQNNYVYI
610 620 630 640 650
MADTEEALME AKTRVDMASG ASDSNVPQLK IGELYDGKIV SVVDFGLFVV
660 670 680 690 700
LPNKQEGLVH ISEISKNRVN DIRADYTEGQ AVTVRIKDIG SDGKIKLTMR
710 720 730 740 750
IDEDRVGSGG SSSSPKKRFG AHPRKNGKDN RSNNSERGFN ERSGSAEGSS

ISRKRFF
Length:757
Mass (Da):82,011
Last modified:March 21, 2006 - v1
Checksum:i850C9F558A54A16D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA. Translation: ABD46123.1.
RefSeqiWP_011451464.1. NC_007798.1.

Genome annotation databases

EnsemblBacteriaiABD46123; ABD46123; NSE_0057.
KEGGinse:NSE_0057.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNP_NEOSM
AccessioniPrimary (citable) accession number: Q2GEY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2006
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families