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Q2GDY1 (NUOA_NEOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit A

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit A
NDH-1 subunit A
NUO1
Gene names
Name:nuoA
Ordered Locus Names:NSE_0429
OrganismNeorickettsia sennetsu (strain Miyayama) [Complete proteome] [HAMAP]
Taxonomic identifier222891 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01394

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01394

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01394.

Sequence similarities

Belongs to the complex I subunit 3 family.

Sequence caution

The sequence ABD45956.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (quinone) activity

Inferred from sequence alignment. Source: TIGR

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 130130NADH-quinone oxidoreductase subunit A HAMAP-Rule MF_01394
PRO_0000362705

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane99 – 11921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2GDY1 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: B3835B3675DC6972

FASTA13014,633
        10         20         30         40         50         60 
MLESSVVGIG KWVVEDYIFV GLFFVVACFI SCVMLALPVF IAPSSHERHK GDSYECGFDK 

        70         80         90        100        110        120 
LSSTGERFNV RFYLVGILFI IFDLEIIFLF PWAVSARELG PAAFVSVLIF LIILTVGFVY 

       130 
EFVSGALDWR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000237 Genomic DNA. Translation: ABD45956.1. Different initiation.
RefSeqYP_506315.1. NC_007798.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222891.NSE_0429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD45956; ABD45956; NSE_0429.
GeneID3932227.
KEGGnse:NSE_0429.
PATRIC22680913. VBINeoSen119815_0385.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0838.
HOGENOMHOG000100119.
KOK00330.
OrthoDBEOG6QVRQ6.

Enzyme and pathway databases

BioCycNSEN222891:GHFU-430-MONOMER.

Family and domain databases

HAMAPMF_01394. NDH1_NuoA.
InterProIPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERPTHR11058. PTHR11058. 1 hit.
PfamPF00507. Oxidored_q4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOA_NEOSM
AccessionPrimary (citable) accession number: Q2GDY1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families