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Q2GDY1

- NUOA_NEOSM

UniProt

Q2GDY1 - NUOA_NEOSM

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Protein
NADH-quinone oxidoreductase subunit A
Gene
nuoA, NSE_0429
Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: TIGR
  2. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  3. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciNSEN222891:GHFU-430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit A (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit A
NDH-1 subunit A
NUO1
Gene namesi
Name:nuoA
Ordered Locus Names:NSE_0429
OrganismiNeorickettsia sennetsu (strain Miyayama)
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
ProteomesiUP000001942: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei74 – 9421Helical; Reviewed prediction
Add
BLAST
Transmembranei99 – 11921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130NADH-quinone oxidoreductase subunit AUniRule annotation
PRO_0000362705Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Protein-protein interaction databases

STRINGi222891.NSE_0429.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0838.
HOGENOMiHOG000100119.
KOiK00330.
OrthoDBiEOG6QVRQ6.

Family and domain databases

HAMAPiMF_01394. NDH1_NuoA.
InterProiIPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GDY1-1 [UniParc]FASTAAdd to Basket

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MLESSVVGIG KWVVEDYIFV GLFFVVACFI SCVMLALPVF IAPSSHERHK    50
GDSYECGFDK LSSTGERFNV RFYLVGILFI IFDLEIIFLF PWAVSARELG 100
PAAFVSVLIF LIILTVGFVY EFVSGALDWR 130
Length:130
Mass (Da):14,633
Last modified:February 10, 2009 - v2
Checksum:iB3835B3675DC6972
GO

Sequence cautioni

The sequence ABD45956.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000237 Genomic DNA. Translation: ABD45956.1. Different initiation.
RefSeqiYP_506315.1. NC_007798.1.

Genome annotation databases

EnsemblBacteriaiABD45956; ABD45956; NSE_0429.
GeneIDi3932227.
KEGGinse:NSE_0429.
PATRICi22680913. VBINeoSen119815_0385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000237 Genomic DNA. Translation: ABD45956.1 . Different initiation.
RefSeqi YP_506315.1. NC_007798.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 222891.NSE_0429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD45956 ; ABD45956 ; NSE_0429 .
GeneIDi 3932227.
KEGGi nse:NSE_0429.
PATRICi 22680913. VBINeoSen119815_0385.

Phylogenomic databases

eggNOGi COG0838.
HOGENOMi HOG000100119.
KOi K00330.
OrthoDBi EOG6QVRQ6.

Enzyme and pathway databases

BioCyci NSEN222891:GHFU-430-MONOMER.

Family and domain databases

HAMAPi MF_01394. NDH1_NuoA.
InterProi IPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view ]
PANTHERi PTHR11058. PTHR11058. 1 hit.
Pfami PF00507. Oxidored_q4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Miyayama.

Entry informationi

Entry nameiNUOA_NEOSM
AccessioniPrimary (citable) accession number: Q2GDY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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