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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei610 – 6101ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNSEN222891:GHFU-508-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NSE_0506
OrganismiNeorickettsia sennetsu (strain Miyayama)
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
ProteomesiUP000001942 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Leucine--tRNA ligasePRO_0000334782Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi222891.NSE_0506.

Structurei

3D structure databases

ProteinModelPortaliQ2GDQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi607 – 6115"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GDQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNYDFKKIE QFSQSLWDFS SCDFQRKKYY VLSMFPYPSG KLHIGHLRNY
60 70 80 90 100
VIGDVLARYK RSQGYNVLHP IGWDAFGLPA EKAAINSNIH PRIWTEKNIA
110 120 130 140 150
KMRTSLKSIG LSYDWSRELS TCSPKYYEHE QKFFLAFLKA GLAYRKNSEV
160 170 180 190 200
NWDPIDKTVL ANEQVIDGRG WRSGAVVVKR KIPQWFLKIS DFSEELLKGL
210 220 230 240 250
ESLTGWPEKV KTMQTNWIGK SEGAVIKFSI SGYEERFIEV FTTRPETIFG
260 270 280 290 300
ASFCAISVNH PLVNELNLLS NAEREILRIQ TTCESDHYDD NKNFSGTTNL
310 320 330 340 350
EKVHEQKLGI LTKIKVKHPF SGDELPLYVA NFVFAEYGSG AIFGCPAHDT
360 370 380 390 400
RDFAFAQQYN LPCLRVISAK CTNTALPYCL EEGVMCNSNF LDGMQVIEAR
410 420 430 440 450
KFIIEKISSI GIGEAKNSYR LRDWGISRQR YWGCPIPVVY CEKCSMQPVK
460 470 480 490 500
VEDLPVTLPE EVEFTVQGNP LEHHPTWKYT NCPKCGGPAV RDTDTFDTFF
510 520 530 540 550
ESSWYFAAFC SKEGGIVKES CKRFLPVDMY IGGIEHAILH LLYARFFTRA
560 570 580 590 600
LNKCGYIDIV EPFRNLLTQG MVCHETYQNS SGEYLYPEEA KSLLEKGEKV
610 620 630 640 650
LVGKIEKMSK SKKNVVDLEE IVSKYGADAA RFFILSDNPP ENSFGWSDRG
660 670 680 690 700
INASFKFLQR IKNLVERYLS SKNSGEVQTG QNVKIQINKI ICDMTKYMDE
710 720 730 740 750
IKLNCAVAKI HELVNLLSAS GALSKETIHV LLRILEPFAP HLAEYLASKL
760 770 780 790 800
ENNVILYGSP WVAYNEVLTQ SDAVTLMVRK NGKFVQLLEV KKDSSEEEII
810 820 830
SQAKRLIKNA VVDKVIYVPG KMVNFLCSSP G
Length:831
Mass (Da):94,528
Last modified:May 20, 2008 - v2
Checksum:i716F59F6F03C73FF
GO

Sequence cautioni

The sequence ABD46464.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA. Translation: ABD46464.1. Different initiation.
RefSeqiWP_041917503.1. NC_007798.1.

Genome annotation databases

EnsemblBacteriaiABD46464; ABD46464; NSE_0506.
KEGGinse:NSE_0506.
PATRICi22681061. VBINeoSen119815_0457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA. Translation: ABD46464.1. Different initiation.
RefSeqiWP_041917503.1. NC_007798.1.

3D structure databases

ProteinModelPortaliQ2GDQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222891.NSE_0506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD46464; ABD46464; NSE_0506.
KEGGinse:NSE_0506.
PATRICi22681061. VBINeoSen119815_0457.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciNSEN222891:GHFU-508-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Miyayama.

Entry informationi

Entry nameiSYL_NEOSM
AccessioniPrimary (citable) accession number: Q2GDQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 22, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.