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Q2GDQ6 (SYL_NEOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:NSE_0506
OrganismNeorickettsia sennetsu (strain Miyayama) [Complete proteome] [HAMAP]
Taxonomic identifier222891 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence ABD46464.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 831831Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334782

Regions

Motif36 – 4611"HIGH" region HAMAP-Rule MF_00049
Motif607 – 6115"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6101ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GDQ6 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 716F59F6F03C73FF

FASTA83194,528
        10         20         30         40         50         60 
MSNYDFKKIE QFSQSLWDFS SCDFQRKKYY VLSMFPYPSG KLHIGHLRNY VIGDVLARYK 

        70         80         90        100        110        120 
RSQGYNVLHP IGWDAFGLPA EKAAINSNIH PRIWTEKNIA KMRTSLKSIG LSYDWSRELS 

       130        140        150        160        170        180 
TCSPKYYEHE QKFFLAFLKA GLAYRKNSEV NWDPIDKTVL ANEQVIDGRG WRSGAVVVKR 

       190        200        210        220        230        240 
KIPQWFLKIS DFSEELLKGL ESLTGWPEKV KTMQTNWIGK SEGAVIKFSI SGYEERFIEV 

       250        260        270        280        290        300 
FTTRPETIFG ASFCAISVNH PLVNELNLLS NAEREILRIQ TTCESDHYDD NKNFSGTTNL 

       310        320        330        340        350        360 
EKVHEQKLGI LTKIKVKHPF SGDELPLYVA NFVFAEYGSG AIFGCPAHDT RDFAFAQQYN 

       370        380        390        400        410        420 
LPCLRVISAK CTNTALPYCL EEGVMCNSNF LDGMQVIEAR KFIIEKISSI GIGEAKNSYR 

       430        440        450        460        470        480 
LRDWGISRQR YWGCPIPVVY CEKCSMQPVK VEDLPVTLPE EVEFTVQGNP LEHHPTWKYT 

       490        500        510        520        530        540 
NCPKCGGPAV RDTDTFDTFF ESSWYFAAFC SKEGGIVKES CKRFLPVDMY IGGIEHAILH 

       550        560        570        580        590        600 
LLYARFFTRA LNKCGYIDIV EPFRNLLTQG MVCHETYQNS SGEYLYPEEA KSLLEKGEKV 

       610        620        630        640        650        660 
LVGKIEKMSK SKKNVVDLEE IVSKYGADAA RFFILSDNPP ENSFGWSDRG INASFKFLQR 

       670        680        690        700        710        720 
IKNLVERYLS SKNSGEVQTG QNVKIQINKI ICDMTKYMDE IKLNCAVAKI HELVNLLSAS 

       730        740        750        760        770        780 
GALSKETIHV LLRILEPFAP HLAEYLASKL ENNVILYGSP WVAYNEVLTQ SDAVTLMVRK 

       790        800        810        820        830 
NGKFVQLLEV KKDSSEEEII SQAKRLIKNA VVDKVIYVPG KMVNFLCSSP G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000237 Genomic DNA. Translation: ABD46464.1. Different initiation.
RefSeqYP_506390.1. NC_007798.1.

3D structure databases

ProteinModelPortalQ2GDQ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222891.NSE_0506.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD46464; ABD46464; NSE_0506.
GeneID3931695.
KEGGnse:NSE_0506.
PATRIC22681061. VBINeoSen119815_0457.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycNSEN222891:GHFU-508-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_NEOSM
AccessionPrimary (citable) accession number: Q2GDQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries