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Q2GDQ6

- SYL_NEOSM

UniProt

Q2GDQ6 - SYL_NEOSM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei610 – 6101ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNSEN222891:GHFU-508-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:NSE_0506
    OrganismiNeorickettsia sennetsu (strain Miyayama)
    Taxonomic identifieri222891 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
    ProteomesiUP000001942: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 831831Leucine--tRNA ligasePRO_0000334782Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi222891.NSE_0506.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GDQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi607 – 6115"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2GDQ6-1 [UniParc]FASTAAdd to Basket

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    MSNYDFKKIE QFSQSLWDFS SCDFQRKKYY VLSMFPYPSG KLHIGHLRNY    50
    VIGDVLARYK RSQGYNVLHP IGWDAFGLPA EKAAINSNIH PRIWTEKNIA 100
    KMRTSLKSIG LSYDWSRELS TCSPKYYEHE QKFFLAFLKA GLAYRKNSEV 150
    NWDPIDKTVL ANEQVIDGRG WRSGAVVVKR KIPQWFLKIS DFSEELLKGL 200
    ESLTGWPEKV KTMQTNWIGK SEGAVIKFSI SGYEERFIEV FTTRPETIFG 250
    ASFCAISVNH PLVNELNLLS NAEREILRIQ TTCESDHYDD NKNFSGTTNL 300
    EKVHEQKLGI LTKIKVKHPF SGDELPLYVA NFVFAEYGSG AIFGCPAHDT 350
    RDFAFAQQYN LPCLRVISAK CTNTALPYCL EEGVMCNSNF LDGMQVIEAR 400
    KFIIEKISSI GIGEAKNSYR LRDWGISRQR YWGCPIPVVY CEKCSMQPVK 450
    VEDLPVTLPE EVEFTVQGNP LEHHPTWKYT NCPKCGGPAV RDTDTFDTFF 500
    ESSWYFAAFC SKEGGIVKES CKRFLPVDMY IGGIEHAILH LLYARFFTRA 550
    LNKCGYIDIV EPFRNLLTQG MVCHETYQNS SGEYLYPEEA KSLLEKGEKV 600
    LVGKIEKMSK SKKNVVDLEE IVSKYGADAA RFFILSDNPP ENSFGWSDRG 650
    INASFKFLQR IKNLVERYLS SKNSGEVQTG QNVKIQINKI ICDMTKYMDE 700
    IKLNCAVAKI HELVNLLSAS GALSKETIHV LLRILEPFAP HLAEYLASKL 750
    ENNVILYGSP WVAYNEVLTQ SDAVTLMVRK NGKFVQLLEV KKDSSEEEII 800
    SQAKRLIKNA VVDKVIYVPG KMVNFLCSSP G 831
    Length:831
    Mass (Da):94,528
    Last modified:May 20, 2008 - v2
    Checksum:i716F59F6F03C73FF
    GO

    Sequence cautioni

    The sequence ABD46464.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD46464.1. Different initiation.
    RefSeqiYP_506390.1. NC_007798.1.

    Genome annotation databases

    EnsemblBacteriaiABD46464; ABD46464; NSE_0506.
    GeneIDi3931695.
    KEGGinse:NSE_0506.
    PATRICi22681061. VBINeoSen119815_0457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD46464.1 . Different initiation.
    RefSeqi YP_506390.1. NC_007798.1.

    3D structure databases

    ProteinModelPortali Q2GDQ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222891.NSE_0506.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD46464 ; ABD46464 ; NSE_0506 .
    GeneIDi 3931695.
    KEGGi nse:NSE_0506.
    PATRICi 22681061. VBINeoSen119815_0457.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci NSEN222891:GHFU-508-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Miyayama.

    Entry informationi

    Entry nameiSYL_NEOSM
    AccessioniPrimary (citable) accession number: Q2GDQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3