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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei233ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNSEN222891:G1G5M-424-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:NSE_0518
OrganismiNeorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
Proteomesi
  • UP000001942 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677181 – 433Glutamate--tRNA ligase 1Add BLAST433

Proteomic databases

PRIDEiQ2GDP4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi222891.NSE_0518

Structurei

3D structure databases

ProteinModelPortaliQ2GDP4
SMRiQ2GDP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 17"HIGH" regionUniRule annotationAdd BLAST11
Motifi230 – 234"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q2GDP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITRFAPSPT GLIHLGNART ALIAYFAARS SGGEFILRID DTDVTRIKSE
60 70 80 90 100
YVNKIFTDLS WLGIKEDLCI KQSERCELYA NAVVKLKESG RIYPCYETPE
110 120 130 140 150
ELEIERRSLL ARALPPVYRR KNRPQHSTRL PYYRFELDPD RVVIWEDKLR
160 170 180 190 200
GKIVIDLHST SDPIVIRENG TYTYMLPSVV DDIECRISTI IRGEDHISNT
210 220 230 240 250
AVQIQMFEAL GCTEIPKFAH MPLLKLQTGK MSKRAGGNEI QTFRENYIEP
260 270 280 290 300
EVICLYLLNL GSKSRSTFKN YKDYSNFNLE NYSSSSSVTV LEDEIYSLNA
310 320 330 340 350
DFLRLSNYED LARRLGGVSK TFWDAVKNNV KSIPEVNYWW EICTTEAKLY
360 370 380 390 400
PGIGCNAQLV RDAISVLPQE EVSRETYRRW VELIVENYRY DKREVHINLR
410 420 430
LALTGKVGGP EMAAILPFIS RERILIRLND SLS
Length:433
Mass (Da):49,866
Last modified:March 21, 2006 - v1
Checksum:i862FFB1C69E5A119
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA Translation: ABD46392.1
RefSeqiWP_011451908.1, NC_007798.1

Genome annotation databases

EnsemblBacteriaiABD46392; ABD46392; NSE_0518
KEGGinse:NSE_0518

Similar proteinsi

Entry informationi

Entry nameiSYE1_NEOSM
AccessioniPrimary (citable) accession number: Q2GDP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 21, 2006
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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