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Q2GCL0

- TRMB_NEOSM

UniProt

Q2GCL0 - TRMB_NEOSM

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionineUniRule annotation
Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation
Binding sitei108 – 1081S-adenosyl-L-methionineUniRule annotation
Active sitei130 – 1301By similarity
Binding sitei130 – 1301S-adenosyl-L-methionineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciNSEN222891:GHFU-925-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:NSE_0922
OrganismiNeorickettsia sennetsu (strain Miyayama)
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
ProteomesiUP000001942: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217tRNA (guanine-N(7)-)-methyltransferasePRO_0000288188Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi222891.NSE_0922.

Structurei

3D structure databases

ProteinModelPortaliQ2GCL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000154684.
KOiK03439.
OMAiGRNFREN.
OrthoDBiEOG6K6VBC.

Family and domain databases

HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GCL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVHNEVNLR LEKKQFLRSY GRRRGRNFRE NKLVGLERFL ASHEKLENLK
60 70 80 90 100
SEIVLEVGFG FGEHILKKAI DYPDKVFVGA EVYVNGIARL LEQVELHELS
110 120 130 140 150
NVLIWNDDVR LLLEKLLCKV FHKVYILFPD PWPKRRHHKR RIVDVPFFQL
160 170 180 190 200
LSRSLHPLAE VVVATDDHDY AQQIYQSALE VFSKVENTEI PKNASRFASK
210
ASNRIFGYKM VYDATDA
Length:217
Mass (Da):25,437
Last modified:March 21, 2006 - v1
Checksum:iFCFAB0446C593638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA. Translation: ABD46256.1.
RefSeqiYP_506786.1. NC_007798.1.

Genome annotation databases

EnsemblBacteriaiABD46256; ABD46256; NSE_0922.
GeneIDi3932004.
KEGGinse:NSE_0922.
PATRICi22681829. VBINeoSen119815_0824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA. Translation: ABD46256.1 .
RefSeqi YP_506786.1. NC_007798.1.

3D structure databases

ProteinModelPortali Q2GCL0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 222891.NSE_0922.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD46256 ; ABD46256 ; NSE_0922 .
GeneIDi 3932004.
KEGGi nse:NSE_0922.
PATRICi 22681829. VBINeoSen119815_0824.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000154684.
KOi K03439.
OMAi GRNFREN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci NSEN222891:GHFU-925-MONOMER.

Family and domain databases

HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Miyayama.

Entry informationi

Entry nameiTRMB_NEOSM
AccessioniPrimary (citable) accession number: Q2GCL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 21, 2006
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3