Q2GCH9 (Q2GCH9_NEOSM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase EMBL ABD45812.1
EC=2.3.1.12 EMBL ABD45812.1

Gene names

Name:	pdhC EMBL ABD45812.1
Ordered Locus Names:	NSE_0953

Organism

Neorickettsia sennetsu (strain Miyayama) [Complete proteome] [HAMAP] EMBL ABD45812.1

Taxonomic identifier

222891 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Neorickettsia › Ehrlichia sennetsu

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423 Contains 1 lipoyl-binding domain. RuleBase RU000447

Ontologies

Keywords
Domain	Lipoyl SAAS SAAS003016 RuleBase RU000447
Ligand	Pyruvate EMBL ABD45812.1
Molecular function	Acyltransferase RuleBase RU003765 EMBL ABD45812.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyruvate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	pyruvate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	dihydrolipoyllysine-residue acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2GCH9 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 44CBB7D9749F7C7E	FASTA	403	43,468
	10 20 30 40 50 60 MPVKILMPAL SPTMKEGTLA KWLVSEGEKI EAGQVIAEIE TDKATMEFEA VDEGVLGKIL 70 80 90 100 110 120 IPAKTAGVKV NQPIAVLLDD GEGEKELKKF LSTIDKPTVT DNKAETSDGD KIKNNPSSLP 130 140 150 160 170 180 ADKQQGRVIA TPLARKIASI NGIDLSLIGS GSGPDGRIVK NDLLKLLDDA PQVQMHGHCT 190 200 210 220 230 240 ETSIPISPMR RVIAQRLVES KQNVPHFYLS VTCYLQHLLS AKKKFYDCLE TKVTVNDFVI 250 260 270 280 290 300 KACAFALDKN PAMNVSWEGE FIRQNQTIDI SVAVAIPDGL ITPIVFSADK LSLSSISDEV 310 320 330 340 350 360 RELVDKAKAG RLQPREFQGG SFTVSNLGMY GIDEFTAIIN PPQAAILAVG AARKVPTVSA 370 380 390 400 DAVVVSDVVT LTLSCDHRVI DGALAARFMQ SLKKAIEDPV IML

References

[1]

"Comparative genomics of emerging human ehrlichiosis agents." Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N. , Nelson W., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H. PLoS Genet. 2:E21-E21(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Miyayama.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000237 Genomic DNA. Translation: ABD45812.1.
RefSeq	YP_506817.1. NC_007798.1.
3D structure databases
ProteinModelPortal	Q2GCH9.
ModBase	Search...
Protein-protein interaction databases
STRING	222891.NSE_0953.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD45812; ABD45812; NSE_0953.
GeneID	3931514.
KEGG	nse:NSE_0953.
PATRIC	22681879. VBINeoSen119815_0849.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0508.
HOGENOM	HOG000281566.
KO	K00627.
OMA	ETSIPIS.
ProtClustDB	CLSK2527759.
Enzyme and pathway databases
BioCyc	NSEN222891:GHFU-956-MONOMER.
Family and domain databases
Gene3D	3.30.559.10. 1 hit. 4.10.320.10. 1 hit.
InterPro	IPR003016. 2-oxoA_DH_lipoyl-BS. IPR001078. 2-oxoacid_DH_actylTfrase. IPR000089. Biotin_lipoyl. IPR023213. CAT-like_dom. IPR004167. E3-bd. IPR006257. LAT1. IPR011053. Single_hybrid_motif. [Graphical view]
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00364. Biotin_lipoyl. 1 hit. PF02817. E3_binding. 1 hit. [Graphical view]
SUPFAM	SSF47005. E3_bd. 1 hit. SSF51230. Hybrid_motif. 1 hit.
TIGRFAMs	TIGR01349. PDHac_trf_mito. 1 hit.
PROSITE	PS50968. BIOTINYL_LIPOYL. 1 hit. PS00189. LIPOYL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2GCH9_NEOSM

Accession

Primary (citable) accession number: Q2GCH9

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	May 29, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)