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Q2GCH9

- Q2GCH9_NEOSM

UniProt

Q2GCH9 - Q2GCH9_NEOSM

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhC

Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciNSEN222891:GHFU-956-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:pdhCImported
    Ordered Locus Names:NSE_0953Imported
    OrganismiNeorickettsia sennetsu (strain Miyayama)Imported
    Taxonomic identifieri222891 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
    ProteomesiUP000001942: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi222891.NSE_0953.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GCH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281566.
    KOiK00627.
    OMAiPERIMEP.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2GCH9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVKILMPAL SPTMKEGTLA KWLVSEGEKI EAGQVIAEIE TDKATMEFEA    50
    VDEGVLGKIL IPAKTAGVKV NQPIAVLLDD GEGEKELKKF LSTIDKPTVT 100
    DNKAETSDGD KIKNNPSSLP ADKQQGRVIA TPLARKIASI NGIDLSLIGS 150
    GSGPDGRIVK NDLLKLLDDA PQVQMHGHCT ETSIPISPMR RVIAQRLVES 200
    KQNVPHFYLS VTCYLQHLLS AKKKFYDCLE TKVTVNDFVI KACAFALDKN 250
    PAMNVSWEGE FIRQNQTIDI SVAVAIPDGL ITPIVFSADK LSLSSISDEV 300
    RELVDKAKAG RLQPREFQGG SFTVSNLGMY GIDEFTAIIN PPQAAILAVG 350
    AARKVPTVSA DAVVVSDVVT LTLSCDHRVI DGALAARFMQ SLKKAIEDPV 400
    IML 403
    Length:403
    Mass (Da):43,468
    Last modified:March 21, 2006 - v1
    Checksum:i44CBB7D9749F7C7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD45812.1.
    RefSeqiYP_506817.1. NC_007798.1.

    Genome annotation databases

    EnsemblBacteriaiABD45812; ABD45812; NSE_0953.
    GeneIDi3931514.
    KEGGinse:NSE_0953.
    PATRICi22681879. VBINeoSen119815_0849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD45812.1 .
    RefSeqi YP_506817.1. NC_007798.1.

    3D structure databases

    ProteinModelPortali Q2GCH9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222891.NSE_0953.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD45812 ; ABD45812 ; NSE_0953 .
    GeneIDi 3931514.
    KEGGi nse:NSE_0953.
    PATRICi 22681879. VBINeoSen119815_0849.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281566.
    KOi K00627.
    OMAi PERIMEP.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci NSEN222891:GHFU-956-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MiyayamaImported.

    Entry informationi

    Entry nameiQ2GCH9_NEOSM
    AccessioniPrimary (citable) accession number: Q2GCH9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3