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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhC

Organism
Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
LigandPyruvateImported

Enzyme and pathway databases

BioCyciNSEN222891:G1G5M-782-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:pdhCImported
Ordered Locus Names:NSE_0953Imported
OrganismiNeorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia sennetsu)Imported
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
Proteomesi
  • UP000001942 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi222891.NSE_0953

Structurei

3D structure databases

ProteinModelPortaliQ2GCH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini129 – 167Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S Bacteria
COG0508 LUCA
HOGENOMiHOG000281566
KOiK00627
OMAiAIMEFES
OrthoDBiPOG091H0NG1

Family and domain databases

Gene3Di3.30.559.101 hit
4.10.320.101 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q2GCH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKILMPAL SPTMKEGTLA KWLVSEGEKI EAGQVIAEIE TDKATMEFEA
60 70 80 90 100
VDEGVLGKIL IPAKTAGVKV NQPIAVLLDD GEGEKELKKF LSTIDKPTVT
110 120 130 140 150
DNKAETSDGD KIKNNPSSLP ADKQQGRVIA TPLARKIASI NGIDLSLIGS
160 170 180 190 200
GSGPDGRIVK NDLLKLLDDA PQVQMHGHCT ETSIPISPMR RVIAQRLVES
210 220 230 240 250
KQNVPHFYLS VTCYLQHLLS AKKKFYDCLE TKVTVNDFVI KACAFALDKN
260 270 280 290 300
PAMNVSWEGE FIRQNQTIDI SVAVAIPDGL ITPIVFSADK LSLSSISDEV
310 320 330 340 350
RELVDKAKAG RLQPREFQGG SFTVSNLGMY GIDEFTAIIN PPQAAILAVG
360 370 380 390 400
AARKVPTVSA DAVVVSDVVT LTLSCDHRVI DGALAARFMQ SLKKAIEDPV

IML
Length:403
Mass (Da):43,468
Last modified:March 21, 2006 - v1
Checksum:i44CBB7D9749F7C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA Translation: ABD45812.1
RefSeqiWP_011452323.1, NC_007798.1

Genome annotation databases

EnsemblBacteriaiABD45812; ABD45812; NSE_0953
KEGGinse:NSE_0953

Similar proteinsi

Entry informationi

Entry nameiQ2GCH9_NEOSM
AccessioniPrimary (citable) accession number: Q2GCH9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported