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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhC

Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciNSEN222891:GHFU-956-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:pdhCImported
Ordered Locus Names:NSE_0953Imported
OrganismiNeorickettsia sennetsu (strain Miyayama)Imported
Taxonomic identifieri222891 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
ProteomesiUP000001942 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi222891.NSE_0953.

Structurei

3D structure databases

ProteinModelPortaliQ2GCH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281566.
KOiK00627.
OMAiEPVMDND.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2GCH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKILMPAL SPTMKEGTLA KWLVSEGEKI EAGQVIAEIE TDKATMEFEA
60 70 80 90 100
VDEGVLGKIL IPAKTAGVKV NQPIAVLLDD GEGEKELKKF LSTIDKPTVT
110 120 130 140 150
DNKAETSDGD KIKNNPSSLP ADKQQGRVIA TPLARKIASI NGIDLSLIGS
160 170 180 190 200
GSGPDGRIVK NDLLKLLDDA PQVQMHGHCT ETSIPISPMR RVIAQRLVES
210 220 230 240 250
KQNVPHFYLS VTCYLQHLLS AKKKFYDCLE TKVTVNDFVI KACAFALDKN
260 270 280 290 300
PAMNVSWEGE FIRQNQTIDI SVAVAIPDGL ITPIVFSADK LSLSSISDEV
310 320 330 340 350
RELVDKAKAG RLQPREFQGG SFTVSNLGMY GIDEFTAIIN PPQAAILAVG
360 370 380 390 400
AARKVPTVSA DAVVVSDVVT LTLSCDHRVI DGALAARFMQ SLKKAIEDPV

IML
Length:403
Mass (Da):43,468
Last modified:March 21, 2006 - v1
Checksum:i44CBB7D9749F7C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA. Translation: ABD45812.1.
RefSeqiWP_011452323.1. NC_007798.1.

Genome annotation databases

EnsemblBacteriaiABD45812; ABD45812; NSE_0953.
KEGGinse:NSE_0953.
PATRICi22681879. VBINeoSen119815_0849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000237 Genomic DNA. Translation: ABD45812.1.
RefSeqiWP_011452323.1. NC_007798.1.

3D structure databases

ProteinModelPortaliQ2GCH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi222891.NSE_0953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD45812; ABD45812; NSE_0953.
KEGGinse:NSE_0953.
PATRICi22681879. VBINeoSen119815_0849.

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281566.
KOiK00627.
OMAiEPVMDND.
OrthoDBiEOG610413.

Enzyme and pathway databases

BioCyciNSEN222891:GHFU-956-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MiyayamaImported.

Entry informationi

Entry nameiQ2GCH9_NEOSM
AccessioniPrimary (citable) accession number: Q2GCH9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: July 22, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.