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Q2GCH9 (Q2GCH9_NEOSM) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyltransferase component of pyruvate dehydrogenase complex RuleBase RU361137

EC=2.3.1.12 RuleBase RU361137
Gene names
Name:pdhC EMBL ABD45812.1
Ordered Locus Names:NSE_0953 EMBL ABD45812.1
OrganismNeorickettsia sennetsu (strain Miyayama) [Complete proteome] [HAMAP] EMBL ABD45812.1
Taxonomic identifier222891 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity. RuleBase RU361137

Catalytic activity

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. RuleBase RU361137

Cofactor

Binds 1 lipoyl cofactor covalently By similarity. RuleBase RU361137

Binds 2 lipoyl cofactors covalently By similarity. RuleBase RU361137

Binds 3 lipoyl cofactors covalently By similarity. RuleBase RU361137

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU361137

Contains 1 lipoyl-binding domain. RuleBase RU361137

Sequences

Sequence LengthMass (Da)Tools
Q2GCH9 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 44CBB7D9749F7C7E

FASTA40343,468
        10         20         30         40         50         60 
MPVKILMPAL SPTMKEGTLA KWLVSEGEKI EAGQVIAEIE TDKATMEFEA VDEGVLGKIL 

        70         80         90        100        110        120 
IPAKTAGVKV NQPIAVLLDD GEGEKELKKF LSTIDKPTVT DNKAETSDGD KIKNNPSSLP 

       130        140        150        160        170        180 
ADKQQGRVIA TPLARKIASI NGIDLSLIGS GSGPDGRIVK NDLLKLLDDA PQVQMHGHCT 

       190        200        210        220        230        240 
ETSIPISPMR RVIAQRLVES KQNVPHFYLS VTCYLQHLLS AKKKFYDCLE TKVTVNDFVI 

       250        260        270        280        290        300 
KACAFALDKN PAMNVSWEGE FIRQNQTIDI SVAVAIPDGL ITPIVFSADK LSLSSISDEV 

       310        320        330        340        350        360 
RELVDKAKAG RLQPREFQGG SFTVSNLGMY GIDEFTAIIN PPQAAILAVG AARKVPTVSA 

       370        380        390        400 
DAVVVSDVVT LTLSCDHRVI DGALAARFMQ SLKKAIEDPV IML 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000237 Genomic DNA. Translation: ABD45812.1.
RefSeqYP_506817.1. NC_007798.1.

3D structure databases

ProteinModelPortalQ2GCH9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222891.NSE_0953.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD45812; ABD45812; NSE_0953.
GeneID3931514.
KEGGnse:NSE_0953.
PATRIC22681879. VBINeoSen119815_0849.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0508.
HOGENOMHOG000281566.
KOK00627.
OMAPERIMEP.
OrthoDBEOG610413.

Enzyme and pathway databases

BioCycNSEN222891:GHFU-956-MONOMER.

Family and domain databases

Gene3D3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2GCH9_NEOSM
AccessionPrimary (citable) accession number: Q2GCH9
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2006
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)