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Q2GCH7 (RUVC_NEOSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:NSE_0955
OrganismNeorickettsia sennetsu (strain Miyayama) [Complete proteome] [HAMAP]
Taxonomic identifier222891 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 166166Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_1000195266

Sites

Metal binding91Magnesium By similarity
Metal binding701Magnesium By similarity
Metal binding1441Magnesium By similarity
Metal binding1471Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2GCH7 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: 6993C039F7ECC561

FASTA16618,019
        10         20         30         40         50         60 
MSYVALGVDP GLLRTGWAVV EYDGLCNVRY IDSGIVKTAS QGSLSARLEK IHRGISDVIE 

        70         80         90        100        110        120 
KVNPSVAVLE KVFVNNNPYS SLNLAYCRGA LILTLALKGL FIVEFAPSVL KKRITGNGRA 

       130        140        150        160 
TKAQVKYMVE QLLGLDPCLS KYSDLYDALA LAASVTRYDI MEAKGT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000237 Genomic DNA. Translation: ABD46339.1.
RefSeqYP_506819.1. NC_007798.1.

3D structure databases

ProteinModelPortalQ2GCH7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222891.NSE_0955.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD46339; ABD46339; NSE_0955.
GeneID3931536.
KEGGnse:NSE_0955.
PATRIC22681883. VBINeoSen119815_0851.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012181.
KOK01159.
OMAARGACIT.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycNSEN222891:GHFU-958-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVC_NEOSM
AccessionPrimary (citable) accession number: Q2GCH7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 21, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families