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Q2GCH7

- RUVC_NEOSM

UniProt

Q2GCH7 - RUVC_NEOSM

Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91MagnesiumUniRule annotation
    Metal bindingi70 – 701MagnesiumUniRule annotation
    Metal bindingi144 – 1441MagnesiumUniRule annotation
    Metal bindingi147 – 1471MagnesiumUniRule annotation

    GO - Molecular functioni

    1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciNSEN222891:GHFU-958-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
    Alternative name(s):
    Holliday junction nuclease RuvCUniRule annotation
    Holliday junction resolvase RuvCUniRule annotation
    Gene namesi
    Name:ruvCUniRule annotation
    Ordered Locus Names:NSE_0955
    OrganismiNeorickettsia sennetsu (strain Miyayama)
    Taxonomic identifieri222891 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
    ProteomesiUP000001942: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Crossover junction endodeoxyribonuclease RuvCPRO_1000195266Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi222891.NSE_0955.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GCH7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0817.
    HOGENOMiHOG000012181.
    KOiK01159.
    OMAiARGACIT.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00034. RuvC.
    InterProiIPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2GCH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYVALGVDP GLLRTGWAVV EYDGLCNVRY IDSGIVKTAS QGSLSARLEK    50
    IHRGISDVIE KVNPSVAVLE KVFVNNNPYS SLNLAYCRGA LILTLALKGL 100
    FIVEFAPSVL KKRITGNGRA TKAQVKYMVE QLLGLDPCLS KYSDLYDALA 150
    LAASVTRYDI MEAKGT 166
    Length:166
    Mass (Da):18,019
    Last modified:March 21, 2006 - v1
    Checksum:i6993C039F7ECC561
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD46339.1.
    RefSeqiWP_011452325.1. NC_007798.1.
    YP_506819.1. NC_007798.1.

    Genome annotation databases

    EnsemblBacteriaiABD46339; ABD46339; NSE_0955.
    GeneIDi3931536.
    KEGGinse:NSE_0955.
    PATRICi22681883. VBINeoSen119815_0851.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD46339.1 .
    RefSeqi WP_011452325.1. NC_007798.1.
    YP_506819.1. NC_007798.1.

    3D structure databases

    ProteinModelPortali Q2GCH7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222891.NSE_0955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD46339 ; ABD46339 ; NSE_0955 .
    GeneIDi 3931536.
    KEGGi nse:NSE_0955.
    PATRICi 22681883. VBINeoSen119815_0851.

    Phylogenomic databases

    eggNOGi COG0817.
    HOGENOMi HOG000012181.
    KOi K01159.
    OMAi ARGACIT.
    OrthoDBi EOG6RG044.

    Enzyme and pathway databases

    BioCyci NSEN222891:GHFU-958-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00034. RuvC.
    InterProi IPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Miyayama.

    Entry informationi

    Entry nameiRUVC_NEOSM
    AccessioniPrimary (citable) accession number: Q2GCH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3