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Q2GCH6

- MDH_NEOSM

UniProt

Q2GCH6 - MDH_NEOSM

Protein

Malate dehydrogenase

Gene

mdh

Organism
Neorickettsia sennetsu (strain Miyayama)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei32 – 321NADUniRule annotation
    Binding sitei81 – 811SubstrateUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei94 – 941NADUniRule annotation
    Binding sitei119 – 1191SubstrateUniRule annotation
    Binding sitei150 – 1501SubstrateUniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADUniRule annotation
    Nucleotide bindingi117 – 1193NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciNSEN222891:GHFU-959-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:NSE_0956
    OrganismiNeorickettsia sennetsu (strain Miyayama)
    Taxonomic identifieri222891 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeNeorickettsia
    ProteomesiUP000001942: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Malate dehydrogenasePRO_0000241953Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi222891.NSE_0956.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2GCH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiDANIVEC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2GCH6-1 [UniParc]FASTAAdd to Basket

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    MKVSLIGAGN IGGTLAYLIA SKKLASEVEL IDVNGDLARG KALDVSQTLP    50
    LIGYTMKING SANMERIKGS SVIIITAGIP RKPGMTREEL IDVNAVVMKE 100
    VGEKIKKFAP KAFVIVVTNP LDVMVWVLYK AAEISPDKIV GMAGVLDASR 150
    MNLFLAQELG VSVADVKSLV LGSHGDSMVP LFRHSTVSGM SLPELVSVGL 200
    ITKDKVDSII ERTRSGGAEI VALLKTGSAY YTPAASVLEM AEAYLLDQKK 250
    TLVCSVMMRG RYGVEDDIFS GIPVIMGSGG VERVIELDLT PDERRMFENS 300
    VAATRKLVLE ARKYF 315
    Length:315
    Mass (Da):33,852
    Last modified:March 21, 2006 - v1
    Checksum:iAA00CCDA40190A52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD46433.1.
    RefSeqiYP_506820.1. NC_007798.1.

    Genome annotation databases

    EnsemblBacteriaiABD46433; ABD46433; NSE_0956.
    GeneIDi3931592.
    KEGGinse:NSE_0956.
    PATRICi22681885. VBINeoSen119815_0852.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000237 Genomic DNA. Translation: ABD46433.1 .
    RefSeqi YP_506820.1. NC_007798.1.

    3D structure databases

    ProteinModelPortali Q2GCH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222891.NSE_0956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD46433 ; ABD46433 ; NSE_0956 .
    GeneIDi 3931592.
    KEGGi nse:NSE_0956.
    PATRICi 22681885. VBINeoSen119815_0852.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi DANIVEC.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci NSEN222891:GHFU-959-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Miyayama.

    Entry informationi

    Entry nameiMDH_NEOSM
    AccessioniPrimary (citable) accession number: Q2GCH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3