Q2GAJ4 (GLND_NOVAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
[Protein-PII] uridylyltransferase
Short name=PII uridylyl-transferase
EC=2.7.7.59

Alternative name(s):
UTase
Uridylyl-removing enzyme

Gene names

Name:	glnD
Ordered Locus Names:	Saro_0682

Organism

Novosphingobium aromaticivorans (strain DSM 12444) [Complete proteome] [HAMAP]

Taxonomic identifier

279238 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Novosphingobium › Sphingomonas aromaticivorans

Protein attributes

Sequence length	912 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein By similarity. HAMAP-Rule MF_00277
Catalytic activity	UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]. HAMAP-Rule MF_00277
Sequence similarities	Belongs to the GlnD family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nitrogen fixation Inferred from electronic annotation. Source: HAMAP
Molecular_function	[protein-PII] uridylyltransferase activity Inferred from electronic annotation. Source: HAMAP amino acid binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro phosphoric diester hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 912	912	[Protein-PII] uridylyltransferase HAMAP-Rule MF_00277		PRO_1000078807

Sequences

	Sequence		Length	Mass (Da)
	Q2GAJ4 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: E81AD196FA1A216A	FASTA	912	101,972
	10 20 30 40 50 60 MLPRIANQRA IVDRRALADA VSAAFAEQGD RSRPAVVELL RGALDSGRAE LARRLEARPS 70 80 90 100 110 120 AGTECAHGQA FLVDQLVRVI HDHVVGKVYR ASNRSTGERI AIIAVGGYGR GEMAPHSDVD 130 140 150 160 170 180 IAFVTPIKPT SWCEQVIEAI LYFLWDLGLK VGHSSRSLDE VVRMAKSDLT IRTALLEGRY 190 200 210 220 230 240 VWGDRDLFDA ASARFWNEVV NGTEKQFVAE KLQERNERHK RLGDSRYVVE PNVKEGKGGL 250 260 270 280 290 300 RDLHTLYWIG KYIHKVRDAS ELVDVGLLTA EEYRAFRRAE NFFWAVRCHL HAITRRAEDR 310 320 330 340 350 360 LTFDLQREVA MRMNFADRPG KSAVERFMQY FFLQAKQVGS LTGVFLAQLD GQFARQKRSF 370 380 390 400 410 420 FASLRSRRKK VGPFFIEGGK LGVPAEDTFQ QDPVRLVELF AVAASEKVEI HPEAMRLARR 430 440 450 460 470 480 DAGLIDAAVR KDQRANALFL DVLTSRNDPE TVLRWMNEAG VFGRFVPDFG RVVAQMQFDM 490 500 510 520 530 540 YHHYTVDEHT IRAIGLLASI EKGEAKADHP LASEVVGKVA SRRVLYVATL LHDIAKGRRG 550 560 570 580 590 600 DHSVLGAEVA MKLCPRLGLS AAETELVAWL VRWHLLMSAT AFKRDLADYK TIADFVNTVQ 610 620 630 640 650 660 SQERLRLLLL LTIVDIRAVG PGVWNSWKRQ LLGDLFVSAE EVLRLGHKQH GRAERIIAKK 670 680 690 700 710 720 KAVGAILKER DNLIGTVGRQ LGDAYWIAEP EDIIALNLQQ MDQALGELLS VEAHWYPARG 730 740 750 760 770 780 ATLVTVLAAD HPGLFYRIAG GIHLAGGNII DARIHTARNG TAVDNFLVQD PLGRPLNEAS 790 800 810 820 830 840 QIERLKNAIA DALANRVKLV PQLAARPLAR PRADAFDVRP IVIFDNKASN RFTVIEVGAR 850 860 870 880 890 900 DRPALLNRLA RALFEARLIV HSAHIATYGE RAVDTFYVTD VLGEKVDSEA RMKAVEKRLL 910 EAAEDRKVKD AA

References

[1]

"Complete sequence of Novosphingobium aromaticivorans DSM 12444." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N. , Fredrickson J., Balkwill D., Romine M.F., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 12444.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000248 Genomic DNA. Translation: ABD25129.1.
RefSeq	YP_495963.1. NC_007794.1.
3D structure databases
ProteinModelPortal	Q2GAJ4.
ModBase	Search...
Protein-protein interaction databases
STRING	279238.Saro_0682.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD25129; ABD25129; Saro_0682.
GeneID	3918107.
KEGG	nar:Saro_0682.
PATRIC	22783982. VBINovAro50627_0701.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2844.
HOGENOM	HOG000261779.
KO	K00990.
OMA	SPKVWNA.
ProtClustDB	PRK05092.
Enzyme and pathway databases
BioCyc	NARO279238:GHBU-1375-MONOMER.
Family and domain databases
Gene3D	1.10.3210.10. 1 hit.
HAMAP	MF_00277. PII_uridylyl-transf.
InterPro	IPR002912. ACT_dom. IPR010043. GlnD_Uridyltrans. IPR003607. HD/PDEase_dom. IPR006674. HD_domain. IPR002934. Nucleotidyltransferase. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
PANTHER	PTHR13734:SF1. PTHR13734:SF1. 1 hit.
Pfam	PF01842. ACT. 1 hit. PF08335. GlnD_UR_UTase. 1 hit. PF01966. HD. 1 hit. PF01909. NTP_transf_2. 1 hit. [Graphical view]
PIRSF	PIRSF006288. PII_uridyltransf. 1 hit.
SMART	SM00471. HDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR01693. UTase_glnD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLND_NOVAD

Accession

Primary (citable) accession number: Q2GAJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program