ID   XYLA_NOVAD              Reviewed;         437 AA.
AC   Q2GAB9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Xylose isomerase;
DE            EC=5.3.1.5;
GN   Name=xylA; OrderedLocusNames=Saro_0757;
OS   Novosphingobium aromaticivorans (strain DSM 12444).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Novosphingobium.
OX   NCBI_TaxID=279238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N.,
RA   Fredrickson J., Balkwill D., Romine M.F., Richardson P.;
RT   "Complete sequence of Novosphingobium aromaticivorans DSM 12444.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-xylose = D-xylulose.
CC   -!- COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the xylose isomerase family.
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DR   EMBL; CP000248; ABD25204.1; -; Genomic_DNA.
DR   RefSeq; YP_496038.1; -.
DR   GeneID; 3918581; -.
DR   GenomeReviews; CP000248_GR; Saro_0757.
DR   KEGG; nar:Saro_0757; -.
DR   NMPDR; fig|48935.1.peg.1772; -.
DR   HOGENOM; Q2GAB9; -.
DR   OMA; Q2GAB9; QFLIEPK.
DR   BioCyc; NARO279238:SARO_0757-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009045; F:xylose isomerase activity; IEA:HAMAP.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR   HAMAP; MF_00455; -; 1.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   InterPro; IPR012307; Xyl_isomerase-typ_TIM-brl.
DR   InterPro; IPR013452; Xylose_isom_bac.
DR   InterPro; IPR001998; Xylose_isomerase.
DR   InterPro; IPR018115; Xylose_isomerase_AS.
DR   Gene3D; G3DSA:3.20.20.150; Xyl_isomerase-like_TIM-brl; 1.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PRINTS; PR00688; XYLOSISMRASE.
DR   TIGRFAMs; TIGR02630; xylose_isom_A; 1.
DR   PROSITE; PS51415; XYLOSE_ISOMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm; Isomerase;
KW   Magnesium; Metal-binding; Pentose shunt; Xylose metabolism.
FT   CHAIN         1    437       Xylose isomerase.
FT                                /FTId=PRO_0000236965.
FT   ACT_SITE    102    102       By similarity.
FT   ACT_SITE    105    105       By similarity.
FT   METAL       233    233       Magnesium 1 (By similarity).
FT   METAL       269    269       Magnesium 1 (By similarity).
FT   METAL       269    269       Magnesium 2 (By similarity).
FT   METAL       272    272       Magnesium 2 (By similarity).
FT   METAL       297    297       Magnesium 1 (By similarity).
FT   METAL       308    308       Magnesium 2 (By similarity).
FT   METAL       310    310       Magnesium 2 (By similarity).
FT   METAL       340    340       Magnesium 1 (By similarity).
SQ   SEQUENCE   437 AA;  48845 MW;  68C4F2157114A246 CRC64;
     MSADYFADFQ TVRYEGPDSD NDFAYRWYDK DRVILGKRME DHLRFAVCMW HTFCWPGSDV
     FGAGTFTRPW LQGPMDARNA AAKREAALAF VEKLDVPFYC FHDVDVMAEA EGIGEFRSSF
     AEAVDHLEEL QGKHGRKLLW GTANLFGHPR YMAGAATNPD PEVFAWGASQ VRDALEATHR
     LGGANYVLWG GREGYDSILN TEIGIEQENF GRFLSLVVDH KHRIGFKGTI LIEPKPHEPT
     KHQYDFDTQT VFGFLKRFGL ESEVKVNIEA NHATLSGHTF EHELAMARAL GILGSIDANR
     GDHQNGWDTD QFPNSVEELT LAMLELIRAG GFTDGGFNFD AKVRRQSIDA ADLFHGHIGG
     IDTIAHALVK AAALIEDGKL DAFRAERYAG WQGELGRKIH ADGTTLADIA DIAVARDLAP
     VRRSGRQEWC ENLINRV
//