Q2GAB9 (XYLA_NOVAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	Saro_0757

Organism

Novosphingobium aromaticivorans (strain DSM 12444) [Complete proteome] [HAMAP]

Taxonomic identifier

279238 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Novosphingobium

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Xylose isomerase HAMAP MF_00455		PRO_0000236965
Sites
	Active site	102	1	By similarity
	Active site	105	1	By similarity
	Metal binding	233	1	Magnesium 1 By similarity
	Metal binding	269	1	Magnesium 1 By similarity
	Metal binding	269	1	Magnesium 2 By similarity
	Metal binding	272	1	Magnesium 2 By similarity
	Metal binding	297	1	Magnesium 1 By similarity
	Metal binding	308	1	Magnesium 2 By similarity
	Metal binding	310	1	Magnesium 2 By similarity
	Metal binding	340	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2GAB9 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 68C4F2157114A246	FASTA	437	48,845
	10 20 30 40 50 60 MSADYFADFQ TVRYEGPDSD NDFAYRWYDK DRVILGKRME DHLRFAVCMW HTFCWPGSDV 70 80 90 100 110 120 FGAGTFTRPW LQGPMDARNA AAKREAALAF VEKLDVPFYC FHDVDVMAEA EGIGEFRSSF 130 140 150 160 170 180 AEAVDHLEEL QGKHGRKLLW GTANLFGHPR YMAGAATNPD PEVFAWGASQ VRDALEATHR 190 200 210 220 230 240 LGGANYVLWG GREGYDSILN TEIGIEQENF GRFLSLVVDH KHRIGFKGTI LIEPKPHEPT 250 260 270 280 290 300 KHQYDFDTQT VFGFLKRFGL ESEVKVNIEA NHATLSGHTF EHELAMARAL GILGSIDANR 310 320 330 340 350 360 GDHQNGWDTD QFPNSVEELT LAMLELIRAG GFTDGGFNFD AKVRRQSIDA ADLFHGHIGG 370 380 390 400 410 420 IDTIAHALVK AAALIEDGKL DAFRAERYAG WQGELGRKIH ADGTTLADIA DIAVARDLAP 430 VRRSGRQEWC ENLINRV

References

[1]

"Complete sequence of Novosphingobium aromaticivorans DSM 12444." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N. , Fredrickson J., Balkwill D., Romine M.F., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 12444.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000248 Genomic DNA. Translation: ABD25204.1.
RefSeq	YP_496038.1. NC_007794.1.
3D structure databases
ProteinModelPortal	Q2GAB9.
SMR	Q2GAB9. Positions 3-437.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2GAB9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3918581.
GenomeReviews	Gene locus Saro_0757 in contig CP000248_GR.
KEGG	nar:Saro_0757.
NMPDR	fig|48935.1.peg.1772.
PATRIC	22784138. VBINovAro50627_0778.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2115.
HOGENOM	HBG297199.
OMA	LLGWDTD.
PhylomeDB	Q2GAB9.
ProtClustDB	PRK05474.
Enzyme and pathway databases
BioCyc	NARO279238:SARO_0757-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_NOVAD

Accession

Primary (citable) accession number: Q2GAB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	March 21, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program