ID Q2GA79_NOVAD Unreviewed; 351 AA. AC Q2GA79; DT 21-MAR-2006, integrated into UniProtKB/TrEMBL. DT 21-MAR-2006, sequence version 1. DT 27-MAR-2024, entry version 104. DE SubName: Full=Amidohydrolase 2 {ECO:0000313|EMBL:ABD25244.1}; GN OrderedLocusNames=Saro_0799 {ECO:0000313|EMBL:ABD25244.1}; OS Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG OS 56034 / CIP 105152 / NBRC 16084 / F199). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales; OC Sphingomonadaceae; Novosphingobium. OX NCBI_TaxID=279238 {ECO:0000313|EMBL:ABD25244.1, ECO:0000313|Proteomes:UP000009134}; RN [1] {ECO:0000313|Proteomes:UP000009134} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 RC / F199 {ECO:0000313|Proteomes:UP000009134}; RG US DOE Joint Genome Institute; RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., RA Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., RA Fredrickson J., Balkwill D., Romine M.F., Richardson P.; RT "Complete sequence of Novosphingobium aromaticivorans DSM 12444."; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0007829|PDB:4INF} RP X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) IN COMPLEX WITH CALCIUM. RA Patskovsky Y., Toro R., Bhosle R., Hillerich B., Seidel R.D., RA Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., RA Zencheck W.D., Imker H.J., Gerlt J.A., Raushel F.M., Almo S.C.; RT "Crystal structure of amidohydrolase sarp_0799 (target efi-505250) from RT novosphingobium aromaticivorans."; RL Submitted (JAN-2013) to the PDB data bank. RN [3] {ECO:0007829|PDB:4QS5} RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH MN(2+). RA Patskovsky Y., Vladimirova A., Toro R., Bhosle R., Gerlt J.A., RA Raushel F.M., Almo S.C.; RT "Crystal Structure of 5-CARBOXYVANILLATE Decarboxylase from Novosphingobium RT Aromaticivorans."; RL Submitted (JUL-2014) to the PDB data bank. RN [4] {ECO:0007829|PDB:4QRN} RP X-RAY CRYSTALLOGRAPHY (1.07 ANGSTROMS) IN COMPLEX WITH MANGANESE. RA Patskovsky Y., Vladimirova A., Toro R., Bhosle R., Raushel F.M., Almo S.C.; RT "Crystal Structure of 5-Carboxyvanillate Decarboxylase from Novosphingobium RT Aromaticivorans."; RL Submitted (JUL-2014) to the PDB data bank. RN [5] {ECO:0007829|PDB:4QTG} RP X-RAY CRYSTALLOGRAPHY (1.47 ANGSTROMS) IN COMPLEX WITH MANGANESE. RA Patskovsky Y., Vladimirova A., Toro R., Bhosle R., Raushel F.M., Almo S.C.; RT "Crystal Structure of 5-Carboxyvanillate Decarboxylase LIGW2 from RT Novosphingobium Aromaticivorans."; RL Submitted (JUL-2014) to the PDB data bank. RN [6] {ECO:0007829|PDB:4QS6} RP X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS). RA Patskovsky Y., Vladimirova A., Toro R., Bhosle R., Raushel F.M., Almo S.C.; RT "Crystal Structure of Ligw2 Decarboxylase from Novosphingobium RT Aromaticivorans."; RL Submitted (JUL-2014) to the PDB data bank. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000248; ABD25244.1; -; Genomic_DNA. DR RefSeq; WP_011444458.1; NC_007794.1. DR PDB; 4INF; X-ray; 1.48 A; A/B/C/D=1-351. DR PDB; 4QRN; X-ray; 1.07 A; A/B/C/D=1-351. DR PDB; 4QS5; X-ray; 1.80 A; A/B/C/D=1-351. DR PDB; 4QS6; X-ray; 1.76 A; A/B=1-351. DR PDB; 4QTG; X-ray; 1.47 A; A/B=1-351. DR PDBsum; 4INF; -. DR PDBsum; 4QRN; -. DR PDBsum; 4QS5; -. DR PDBsum; 4QS6; -. DR PDBsum; 4QTG; -. DR AlphaFoldDB; Q2GA79; -. DR SMR; Q2GA79; -. DR STRING; 279238.Saro_0799; -. DR KEGG; nar:Saro_0799; -. DR eggNOG; COG2159; Bacteria. DR HOGENOM; CLU_039329_5_0_5; -. DR Proteomes; UP000009134; Chromosome. DR GO; GO:0016831; F:carboxy-lyase activity; IEA:InterPro. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt. DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1. DR InterPro; IPR032465; ACMSD. DR InterPro; IPR006680; Amidohydro-rel. DR InterPro; IPR032466; Metal_Hydrolase. DR PANTHER; PTHR21240; 2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE; 1. DR PANTHER; PTHR21240:SF27; 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE; 1. DR Pfam; PF04909; Amidohydro_2; 1. DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:4INF, ECO:0007829|PDB:4QRN}; KW Calcium {ECO:0007829|PDB:4INF}; Hydrolase {ECO:0000313|EMBL:ABD25244.1}; KW Lyase {ECO:0000256|ARBA:ARBA00023239}; KW Metal-binding {ECO:0007829|PDB:4INF, ECO:0007829|PDB:4QRN}; KW Reference proteome {ECO:0000313|Proteomes:UP000009134}. FT DOMAIN 99..351 FT /note="Amidohydrolase-related" FT /evidence="ECO:0000259|Pfam:PF04909" FT BINDING 19 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0007829|PDB:4INF" FT BINDING 19 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:4QRN, ECO:0007829|PDB:4QTG" FT BINDING 19 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:4QS5" FT BINDING 188 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0007829|PDB:4INF" FT BINDING 188 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:4QRN, ECO:0007829|PDB:4QTG" FT BINDING 188 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /ligand_label="1" FT /evidence="ECO:0007829|PDB:4QS5" FT BINDING 314 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0007829|PDB:4INF" FT BINDING 314 FT /ligand="Mn(2+)" FT /ligand_id="ChEBI:CHEBI:29035" FT /ligand_label="2" FT /evidence="ECO:0007829|PDB:4QRN, ECO:0007829|PDB:4QTG" SQ SEQUENCE 351 AA; 39852 MW; F60CF52989252B7F CRC64; MTQDLKTGGE QGYLRIATEE AFATREIIDV YLRMIRDGTA DKGMVSLWGF YAQSPSERAT QILERLLDLG ERRIADMDAT GIDKAILALT SPGVQPLHDL DEARTLATRA NDTLADACQK YPDRFIGMGT VAPQDPEWSA REIHRGAREL GFKGIQINSH TQGRYLDEEF FDPIFRALVE VDQPLYIHPA TSPDSMIDPM LEAGLDGAIF GFGVETGMHL LRLITIGIFD KYPSLQIMVG HMGEALPYWL YRLDYMHQAG VRSQRYERMK PLKKTIEGYL KSNVLVTNSG VAWEPAIKFC QQVMGEDRVM YAMDYPYQYV ADEVRAMDAM DMSAQTKKKF FQTNAEKWFK L //