Reviewed, UniProtKB/Swiss-Prot Q2G9T9 (ASTD_NOVAD)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Saro_0939

Organism

Novosphingobium aromaticivorans (strain DSM 12444) [Complete proteome] [HAMAP]

Taxonomic identifier

279238 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Novosphingobium

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_0000262408
Regions
	Nucleotide binding	207 – 212	6	NAD By similarity
Sites
	Active site	230	1	By similarity
	Active site	264	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2G9T9-1 [UniParc]. Last modified March 21, 2006. Version 1. Checksum: 8B31E4237922FAA3	FASTA	471	50,511
	10 20 30 40 50 60 MARAEIVSHE PATGAEVWRG KVGDVEEVVA RARRAWPAWA AQPLATRIEL VRRFANEVRK 70 80 90 100 110 120 DADNLATMIS RETGKPLWEA RTEVDSVVNK VEISIRAYAD RTSQRKLDSA LQGTAALRHK 130 140 150 160 170 180 PHGVLAVLGP YNFPAHLPNG HIVPALIAGN AVVFKPSEKT PATGEMLAQC FHRAGIPAAV 190 200 210 220 230 240 VQVLIGGPEE GQALVAHDGI DGVLFTGSAH AGIAINRKLA SNPGKIVALE MGGNNPIVVW 250 260 270 280 290 300 DTPKIEDAAT LIVQSAFTSA GQRCTAARRL IIKASMFDEV IDHVKRLADR IIVGAPFDDP 310 320 330 340 350 360 APFMGPVIDN RTADGLTESF VYLLSSGGRP IKHMVRLQED RPFLSPAIID VTAVADRPDV 370 380 390 400 410 420 ELFGPLLQVV RVDDFDEAIA EANNTRFGLS ASLIGGDPQD YNRFWANIRA GVVNWNRPTN 430 440 450 460 470 GASSAAPFGG VGLSGNHRPS AYYAADYCAY PVASTEVDQP RASIGVGLRS D

References

[1]

"Complete sequence of Novosphingobium aromaticivorans DSM 12444." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N. , Fredrickson J., Balkwill D., Romine M.F., Richardson P. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000248 Genomic DNA. Translation: ABD25384.1.
RefSeq	YP_496218.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3918025.
GenomeReviews	Gene locus Saro_0939 in contig CP000248_GR.
KEGG	nar:Saro_0939.
NMPDR	fig|48935.1.peg.1063.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2G9T9.
Enzyme and pathway databases
BioCyc	NARO279238:SARO_0939-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_NOVAD

Accession

Primary (citable) accession number: Q2G9T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 21, 2006
Last modified:	November 25, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)